DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Lrrc8d

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001008339.2	Gene:	Lrrc8d / 305131	RGDID:	1309601	Length:	860	Species:	Rattus norvegicus

Alignment Length:	555	Identity:	117/555 - (21%)
Similarity:	197/555 - (35%)	Gaps:	191/555 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LLLQLLLQLLLLPPSAMGHDETKENPA----PDMQN---------------------------SQ 49
            :.|..|..|..:|......::.:|..:    ||::|                           |:
  Rat   381 ICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRFGVFLSEVSE 445

  Fly    50 EQEPYVHLQH------LQQQQQQNPQTVQQLSQITVNRTSKSA-SVTPTGIRENVMLPSAD-PEK 106
            .:...:.|.|      |:|...:|.|..|:|....::....:. .:|...:.:..::|.|. |.|
  Rat   446 NKLREISLNHEWTFEKLRQHVSRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAK 510

  Fly   107 EAQILYEKSLQEYHGSQLSTASTATDVIAGKRTLHSICERWLQKHCHCTGSLE-----VLR--LS 164
            .:|:   .:|||.|                              .|||...:|     .||  |.
  Rat   511 ISQM---TNLQELH------------------------------LCHCPAKVEQTAFSFLRDHLR 542

  Fly   165 CRGIGILAVPVNLPNEVVVLD-------LGN--------------------------NNLTKLEA 196
            |..:....| ..:|..|.:|.       :||                          :||||:.:
  Rat   543 CLHVKFTDV-AEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPS 606

  Fly   197 NSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGN 261
            |...:||:|.:|.:.::....:..|:...:..:..|.||||.|:.:|...| .|:.|..|.|..|
  Rat   607 NITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIF-SLSNLQELDLKSN 670

  Fly   262 ALVSLDGDCLG--HLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPN 324
            ::.::: :.:.  ||::|..|:|..|....||. ::..::.||:|...:|.|     |..|
  Rat   671 SIRTIE-EIISFQHLKRLTCLKLWHNKIVAIPP-SITHVKNLESLYFSNNKL-----ESLP---- 724

  Fly   325 LIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTE 389
                            .|:.:|..|:.|::..|.||::|..:..|..||.|.||.|::     ..
  Rat   725 ----------------VAVFSLQKLRCLDVSYNNISTIPIEIGLLQNLQHLHITGNKV-----DV 768

  Fly   390 LPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEV 454
            ||:                                         :|..|..|..|.|.:..|..:
  Rat   769 LPK-----------------------------------------QLFKCVKLRTLNLGQNCIASL 792

  Fly   455 PANLCRQTPRLKSLELKTNSLKRIP-NLSSCRDLR 488
            |..: .|..:|..||||.|.|.|:| .|..||.|:
  Rat   793 PEKI-SQLSQLTQLELKGNCLDRLPAQLGQCRMLK 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	6/27 (22%)
		LRR_RI	180..>383	CDD:238064	57/237 (24%)
		leucine-rich repeat	183..204	CDD:275380	9/53 (17%)
		LRR_8	203..263	CDD:290566	17/59 (29%)
		leucine-rich repeat	205..228	CDD:275380	3/22 (14%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		LRR_8	252..311	CDD:290566	16/60 (27%)
		leucine-rich repeat	253..276	CDD:275380	6/24 (25%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		LRR_8	299..359	CDD:290566	12/59 (20%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..348	CDD:275380	2/22 (9%)
		LRR_RI	327..567	CDD:238064	38/163 (23%)
		leucine-rich repeat	349..371	CDD:275380	7/21 (33%)
		LRR_8	370..425	CDD:290566	8/54 (15%)
		leucine-rich repeat	372..393	CDD:275380	8/20 (40%)
		leucine-rich repeat	394..415	CDD:275380	0/20 (0%)
		leucine-rich repeat	418..486	CDD:275380	19/68 (28%)
		leucine-rich repeat	441..464	CDD:275378	6/22 (27%)
		LRR_8	487..545	CDD:290566	1/2 (50%)
		leucine-rich repeat	487..510	CDD:275380	1/2 (50%)
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Lrrc8d	NP_001008339.2	Pannexin_like	3..386	CDD:289311	1/4 (25%)
		leucine-rich repeat	517..538	CDD:275378	8/50 (16%)
		LRR_RI	557..834	CDD:238064	80/345 (23%)
		leucine-rich repeat	564..591	CDD:275380	2/26 (8%)
		leucine-rich repeat	592..617	CDD:275380	8/24 (33%)
		LRR_8	638..697	CDD:290566	19/60 (32%)
		leucine-rich repeat	639..661	CDD:275380	9/22 (41%)
		leucine-rich repeat	662..686	CDD:275380	6/24 (25%)
		LRR_8	685..743	CDD:290566	18/83 (22%)
		leucine-rich repeat	687..709	CDD:275380	6/22 (27%)
		leucine-rich repeat	710..732	CDD:275380	9/46 (20%)
		leucine-rich repeat	733..755	CDD:275380	7/21 (33%)
		LRR_8	755..810	CDD:290566	21/101 (21%)
		leucine-rich repeat	756..778	CDD:275380	10/67 (15%)
		leucine-rich repeat	779..801	CDD:275380	6/22 (27%)
		leucine-rich repeat	802..822	CDD:275380	10/19 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910