DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Lrrc8e

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001029311.1	Gene:	Lrrc8e / 304203	RGDID:	1311979	Length:	795	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	135/554 - (24%)
Similarity:	211/554 - (38%)	Gaps:	154/554 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DETKENPAPDMQNSQEQEPYVHLQHL--QQQQQQNPQTVQQLSQITVNRTSK---SASVTPTGIR 94
            :||..|..||::|.     :..:.||  |.....:.:....||:::.:|..:   :...||..:|
  Rat   348 EETGMNDIPDVRND-----FAFMLHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPDKLR 407

  Fly    95 ENVMLPSADPEKEAQILYEKSLQEYHGSQLSTASTATDVIAGKRTLHSICERWLQKHCHCTGSLE 159
            :.:       ::.|:...|.||....|.. .|....::|.|.:  |.:||:....     .|..:
  Rat   408 QKL-------QRNARGRLELSLCMLPGLP-DTVFELSEVEALR--LEAICDISFP-----PGLSQ 457

  Fly   160 VLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAFY 224
            ::.|  :.:.:|..|..||                .::..|:...|:.:.:....:..: |...:
  Rat   458 LVNL--QELSLLHSPARLP----------------FSSQIFLRDRLKVICVKFEELREV-PLWVF 503

  Fly   225 GLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYR 289
            ||..|:.|.|:  ||  .||:..:| |.|.||:               .|::|:.|.|..|. .:
  Rat   504 GLRGLEELHLE--GL--FPPEMARG-ATLESLR---------------ELKQLKVLSLRSNA-GK 547

  Fly   290 IP---TNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKV 351
            :|   |:....|:.|...|.|:.||.:                           .:||.|..|:.
  Rat   548 VPASVTDVAGHLQRLSLHNDGARLLAL---------------------------NSLKKLAVLRE 585

  Fly   352 LELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRGMS 416
            |||....:..:|..:..|..||||.:..|.||.|.:
  Rat   586 LELVACGLERIPHAIFSLGALQELDLKDNHLRSIEE----------------------------- 621

  Fly   417 KLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIP-N 480
                 |||          .:.|..|.||:|....|..||.:: |:...|:.|.|..|.|:.:| .
  Rat   622 -----ILS----------FQHCRKLVILRLWHNQIAYVPEHV-RKLRSLEQLYLSHNKLETLPAQ 670

  Fly   481 LSSCRDLRLLDLSSNQIEKIQGKPFNGLKQ-LNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNE 544
            |..|..|||||:|.|.:..:  .|..||.| |..|.||||.:::||.:.| ...||:.|.|
  Rat   671 LGQCFGLRLLDVSHNGLRSL--PPELGLLQSLQHLALSYNALESLPDELF-FCHKLRTLLL---- 728

  Fly   545 ISYIHKEAFS----GFTALEDLNLGNNIFPELPE 574
             .|.|...||    ...||..|.|..|....|||
  Rat   729 -GYNHLTQFSPHVAALQALSRLELKGNRLEALPE 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	4/20 (20%)
		LRR_RI	180..>383	CDD:238064	44/205 (21%)
		leucine-rich repeat	183..204	CDD:275380	1/20 (5%)
		LRR_8	203..263	CDD:290566	16/59 (27%)
		leucine-rich repeat	205..228	CDD:275380	4/22 (18%)
		leucine-rich repeat	229..252	CDD:275380	8/22 (36%)
		LRR_8	252..311	CDD:290566	14/61 (23%)
		leucine-rich repeat	253..276	CDD:275380	4/22 (18%)
		leucine-rich repeat	277..300	CDD:275380	7/25 (28%)
		LRR_8	299..359	CDD:290566	12/59 (20%)
		leucine-rich repeat	301..324	CDD:275380	5/22 (23%)
		leucine-rich repeat	325..348	CDD:275380	3/22 (14%)
		LRR_RI	327..567	CDD:238064	69/245 (28%)
		leucine-rich repeat	349..371	CDD:275380	6/21 (29%)
		LRR_8	370..425	CDD:290566	10/54 (19%)
		leucine-rich repeat	372..393	CDD:275380	8/20 (40%)
		leucine-rich repeat	394..415	CDD:275380	0/20 (0%)
		leucine-rich repeat	418..486	CDD:275380	20/68 (29%)
		leucine-rich repeat	441..464	CDD:275378	8/22 (36%)
		LRR_8	487..545	CDD:290566	24/58 (41%)
		leucine-rich repeat	487..510	CDD:275380	10/22 (45%)
		leucine-rich repeat	511..534	CDD:275380	9/22 (41%)
		LRR_8	533..589	CDD:290566	16/46 (35%)
		leucine-rich repeat	535..558	CDD:275380	7/26 (27%)
		leucine-rich repeat	559..580	CDD:275380	7/16 (44%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Lrrc8e	NP_001029311.1	Pannexin_like	1..330	CDD:289311
		leucine-rich repeat	508..532	CDD:275380	12/43 (28%)
		LRR_RI	526..790	CDD:238064	89/332 (27%)
		LRR 1	535..556		6/21 (29%)
		leucine-rich repeat	536..558	CDD:275380	6/22 (27%)
		LRR 2	558..578		6/46 (13%)
		leucine-rich repeat	559..582	CDD:275380	9/49 (18%)
		LRR 3	582..603		5/20 (25%)
		LRR_8	583..641	CDD:290566	22/101 (22%)
		leucine-rich repeat	583..605	CDD:275380	6/21 (29%)
		LRR 4	605..626		11/64 (17%)
		leucine-rich repeat	606..630	CDD:275380	12/67 (18%)
		LRR_8	629..687	CDD:290566	23/58 (40%)
		LRR 5	630..651		8/21 (38%)
		leucine-rich repeat	631..653	CDD:275380	8/22 (36%)
		LRR 6	653..674		7/20 (35%)
		leucine-rich repeat	654..676	CDD:275380	8/21 (38%)
		LRR_8	676..733	CDD:290566	25/64 (39%)
		LRR 7	676..697		9/22 (41%)
		leucine-rich repeat	677..699	CDD:275380	10/23 (43%)
		LRR 8	699..720		9/21 (43%)
		leucine-rich repeat	700..722	CDD:275380	9/22 (41%)
		LRR 9	722..743		8/25 (32%)
		leucine-rich repeat	723..745	CDD:275380	7/26 (27%)
		LRR 10	745..766		8/17 (47%)
		leucine-rich repeat	746..766	CDD:275380	7/16 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910