DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Ppp1r7

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001009825.1	Gene:	Ppp1r7 / 301618	RGDID:	1308169	Length:	360	Species:	Rattus norvegicus

Alignment Length:	334	Identity:	88/334 - (26%)
Similarity:	154/334 - (46%)	Gaps:	81/334 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 VSLDGDC----LGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPN 324
            :|||.|.    |.|   .|..::||   :.:       |:.:::|.|..||:..|  |:...:.:
  Rat    72 ISLDRDAEDVDLNH---YRIGKIEG---FEV-------LKKVKSLCLRQNLIKCI--ENLDELQS 121

  Fly   325 LIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTE 389
            |..|.|..|||.||.  .|:.||.|:||::..||:.:: ||:.||:||::|.:.:|::..|.:..
  Rat   122 LRELDLYDNQIKKIE--NLEALTELEVLDISFNLLRNI-EGIDKLTQLKKLFLVNNKINKIENIS 183

  Fly   390 LPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEV 454
            ..:.:|||::.:|.:..|                .::.||.:
  Rat   184 TLQQLQMLELGSNRIRAI----------------ENIDTLTN----------------------- 209

  Fly   455 PANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYN 519
                      |:||.|..|.:.::.||.:..:|.:|.:.||::.||:|  ...|..|.:|.||:|
  Rat   210 ----------LESLFLGKNKITKLQNLDALSNLTVLSMQSNRLTKIEG--LQNLVNLRELYLSHN 262

  Fly   520 RIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNI---FPELPE-SGLRAL 580
            .|:.:  :..:...||.:||:..|.|..|  |..|..|.|::..:.:|:   :.:|.| .|.|:|
  Rat   263 GIEVI--EGLENNNKLTMLDIASNRIKKI--ENISHLTELQEFWMNDNLLESWSDLDELKGARSL 323

  Fly   581 LHLKTFNNP 589
            ..:....||
  Rat   324 ETVYLERNP 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	40/122 (33%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566	13/50 (26%)
		leucine-rich repeat	253..276	CDD:275380	6/15 (40%)
		leucine-rich repeat	277..300	CDD:275380	4/22 (18%)
		LRR_8	299..359	CDD:290566	21/59 (36%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..348	CDD:275380	10/22 (45%)
		LRR_RI	327..567	CDD:238064	63/239 (26%)
		leucine-rich repeat	349..371	CDD:275380	9/21 (43%)
		LRR_8	370..425	CDD:290566	10/54 (19%)
		leucine-rich repeat	372..393	CDD:275380	4/20 (20%)
		leucine-rich repeat	394..415	CDD:275380	5/20 (25%)
		leucine-rich repeat	418..486	CDD:275380	9/67 (13%)
		leucine-rich repeat	441..464	CDD:275378	0/22 (0%)
		LRR_8	487..545	CDD:290566	19/57 (33%)
		leucine-rich repeat	487..510	CDD:275380	8/22 (36%)
		leucine-rich repeat	511..534	CDD:275380	6/22 (27%)
		LRR_8	533..589	CDD:290566	17/59 (29%)
		leucine-rich repeat	535..558	CDD:275380	8/22 (36%)
		leucine-rich repeat	559..580	CDD:275380	6/24 (25%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Ppp1r7	NP_001009825.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..63
		internalin_A	<68..>260	CDD:380193	65/256 (25%)
		LRR 1	77..98		6/33 (18%)
		LRR 2	99..120		6/22 (27%)
		leucine-rich repeat	100..121	CDD:275380	6/22 (27%)
		LRR 3	121..142		9/22 (41%)
		leucine-rich repeat	122..143	CDD:275380	10/22 (45%)
		LRR 4	143..164		8/21 (38%)
		leucine-rich repeat	144..165	CDD:275380	9/21 (43%)
		LRR 5	165..186		5/20 (25%)
		leucine-rich repeat	166..187	CDD:275380	4/20 (20%)
		PPP1R42	169..354	CDD:411060	50/219 (23%)
		LRR 6	187..208		6/36 (17%)
		leucine-rich repeat	188..209	CDD:275380	7/36 (19%)
		LRR 7	209..230		7/53 (13%)
		leucine-rich repeat	210..231	CDD:275380	7/20 (35%)
		LRR 8	231..252		7/22 (32%)
		leucine-rich repeat	232..253	CDD:275380	8/22 (36%)
		LRR 9	253..274		6/22 (27%)
		leucine-rich repeat	254..275	CDD:275380	6/22 (27%)
		LRR 10	275..296		9/22 (41%)
		leucine-rich repeat	276..297	CDD:275380	8/22 (36%)
		LRR 11	297..318		4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910