DRSC/TRiP Functional Genomics Resources

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Protein Alignment rk and Lgr5

DIOPT Version :9

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:NP_001100254.1 Gene:Lgr5 / 299802 RGDID:1307733 Length:907 Species:Rattus norvegicus


Alignment Length:918 Identity:270/918 - (29%)
Similarity:425/918 - (46%) Gaps:117/918 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   133 VIAGKRTLHSICERWLQKHCHC--TGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLE 195
            |.||.........|....:|||  .|.: :||:.|..:|:..:|.||......|||..||:::|.
  Rat    19 VAAGSPPRPDTMPRGCPSYCHCELDGRM-LLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLP 82

  Fly   196 ANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNG 260
            |:.......||||.|:.|::.::...||.||..||.|.|||..|:.:|.::.|.|..|.||:|:.
  Rat    83 ASLLHRLRFLEELRLAGNALTHIPKGAFAGLHSLKVLMLQNNQLRQVPEEALQNLRSLQSLRLDA 147

  Fly   261 NALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNL 325
            |.:..:...|...|..||.|.|:.|....:|..|...|..|:|:.|..|.:..|.|..|..:.:|
  Rat   148 NHISYVPPSCFSGLHSLRHLWLDDNALTDVPVQAFRSLSALQAMTLALNKIHHIADHAFGNLSSL 212

  Fly   326 IVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTEL 390
            :||.|..|:|..:.......|.:|:.|:|:.|.:...|..:..||.|:||...||.:|.|.:...
  Rat   213 VVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIKTLSNLKELGFHSNNIRSIPERAF 277

  Fly   391 PRSMQMLDMR--ANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQE 453
            ..:..::.:.  .||:..:...||:.:.:||.|.|:....:..||:|.....||.|.|..|.|..
  Rat   278 VGNPSLITIHFYDNPIQFVGISAFQHLPELRTLTLNGASQITEFPDLTGTATLESLTLTGAKISS 342

  Fly   454 VPANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSY 518
            :|..:|.|.|.|:.|:|..|.|:.:|:||.|:.|:.:||..|:|.:|:|                
  Rat   343 LPQTVCDQLPNLQVLDLSYNLLEDLPSLSGCQKLQKIDLRHNEIYEIKG---------------- 391

  Fly   519 NRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHL 583
                    ..||.:..|:.|:|..|:|:.||..|||...:|..|:|.:|:....|.:||..|.||
  Rat   392 --------GTFQQLFNLRSLNLARNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPVTGLHGLTHL 448

  Fly   584 KTFNNPKLREFPPPDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTL 648
            |...|..|:...|...||.::.:.:.|||.||||                               
  Rat   449 KLTGNRALQSLIPSANFPELKIIEMPYAYQCCAF------------------------------- 482

  Fly   649 WNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPAT 713
              ....|::...:..:|...:|:.|            |:.:..|      :.:..:|.|:     
  Rat   483 --GGCENVYKIPNQWNKDDSSSVDD------------LRKKDAG------LFQVQDERDL----- 522

  Fly   714 GYGFGTGLFSGMSTEDFQPG---------SVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLL 769
                          |||...         ||||.|.||||.||..||..|.:|.|||...:|:|.
  Rat   523 --------------EDFLLDFEEDLKVLHSVQCSPPPGPFKPCEHLFGSWLIRIGVWTTAVLALS 573

  Fly   770 GNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQ 834
            .|..|.|.:..:...:...:.|:..:|..|..||:...|||:||..|.|.|......|:..:.||
  Rat   574 CNALVAFTVFRTPLYISSIKLLIGVIAVVDILMGVSSAILAVVDTFTFGSFAQHGAWWEGGIGCQ 638

  Fly   835 LSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGV 899
            :.|||::.:||.||:.|.:..|||.:::..:.....:..|.....|:.:..:.||.:|.:||:|.
  Rat   639 IVGFLSIFASESSVFLLTLAALERGFSVKCSSKFEMKAPLSSLKAIILLCVLLALTIATVPLLGG 703

  Fly   900 SDYRKFAVCLPF----ETTTGPASLTYVISLMFINGCAFLTLMGCYLKMYWAIRGSQAWNTNDSR 960
            |:|....:|||.    .:|||     |:::|:.:|...||.:...|.::|.::...:..|..|..
  Rat   704 SEYNASPLCLPLPFGEPSTTG-----YMVALVLLNSLCFLIMTIAYTRLYCSLEKGELENLWDCS 763

  Fly   961 IAKRMALLVFTDFLCWSPIAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFK 1025
            :.|..|||:||:.:.:.|:||.|.:::..|..||.|..|...:.::||.:|.||.||.:....||
  Rat   764 MVKHTALLLFTNCILYCPVAFLSFSSLLNLTFISPEVIKFILLVIVPLPACLNPLLYIVFNPHFK 828

  Fly  1026 KDCVTLCK 1033
            :|..:|.|
  Rat   829 EDMGSLGK 836

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380 7/20 (35%)
LRR_RI 180..>383 CDD:238064 68/202 (34%)
leucine-rich repeat 183..204 CDD:275380 7/20 (35%)
LRR_8 203..263 CDD:290566 25/59 (42%)
leucine-rich repeat 205..228 CDD:275380 10/22 (45%)
leucine-rich repeat 229..252 CDD:275380 10/22 (45%)
LRR_8 252..311 CDD:290566 19/58 (33%)
leucine-rich repeat 253..276 CDD:275380 7/22 (32%)
leucine-rich repeat 277..300 CDD:275380 8/22 (36%)
LRR_8 299..359 CDD:290566 18/59 (31%)
leucine-rich repeat 301..324 CDD:275380 7/22 (32%)
leucine-rich repeat 325..348 CDD:275380 7/22 (32%)
LRR_RI 327..567 CDD:238064 72/241 (30%)
leucine-rich repeat 349..371 CDD:275380 6/21 (29%)
LRR_8 370..425 CDD:290566 16/56 (29%)
leucine-rich repeat 372..393 CDD:275380 7/20 (35%)
leucine-rich repeat 394..415 CDD:275380 4/22 (18%)
leucine-rich repeat 418..486 CDD:275380 26/67 (39%)
leucine-rich repeat 441..464 CDD:275378 9/22 (41%)
LRR_8 487..545 CDD:290566 13/57 (23%)
leucine-rich repeat 487..510 CDD:275380 7/22 (32%)
leucine-rich repeat 511..534 CDD:275380 2/22 (9%)
LRR_8 533..589 CDD:290566 21/55 (38%)
leucine-rich repeat 535..558 CDD:275380 10/22 (45%)
leucine-rich repeat 559..580 CDD:275380 7/20 (35%)
7tm_4 764..>892 CDD:304433 36/127 (28%)
7tm_1 770..1017 CDD:278431 75/250 (30%)
Lgr5NP_001100254.1 LRRNT 33..70 CDD:214470 11/37 (30%)
LRR 1 44..64 6/20 (30%)
LRR 2 65..88 7/22 (32%)
leucine-rich repeat 68..91 CDD:275380 7/22 (32%)
LRR_RI 88..372 CDD:238064 91/283 (32%)
LRR 3 89..112 8/22 (36%)
LRR_8 92..150 CDD:290566 25/57 (44%)
leucine-rich repeat 92..115 CDD:275380 10/22 (45%)
LRR 4 114..136 8/21 (38%)
leucine-rich repeat 116..139 CDD:275380 10/22 (45%)
LRR 5 137..160 7/22 (32%)
LRR_8 138..198 CDD:290566 19/59 (32%)
leucine-rich repeat 140..163 CDD:275380 7/22 (32%)
LRR 6 162..184 7/21 (33%)
leucine-rich repeat 164..187 CDD:275380 8/22 (36%)
LRR 7 186..208 7/21 (33%)
LRR_8 188..246 CDD:290566 18/57 (32%)
leucine-rich repeat 188..211 CDD:275380 7/22 (32%)
LRR 8 209..232 6/22 (27%)
leucine-rich repeat 212..235 CDD:275380 7/22 (32%)
LRR 9 233..256 6/22 (27%)
leucine-rich repeat 236..258 CDD:275380 6/21 (29%)
LRR_8 257..314 CDD:290566 16/56 (29%)
LRR 10 257..279 8/21 (38%)
leucine-rich repeat 259..282 CDD:275380 7/22 (32%)
LRR 11 281..303 4/21 (19%)
leucine-rich repeat 283..304 CDD:275380 4/20 (20%)
LRR 12 304..327 7/22 (32%)
leucine-rich repeat 307..353 CDD:275380 16/45 (36%)
LRR 13 328..350 8/21 (38%)
LRR 14 351..375 10/23 (43%)
LRR_8 352..410 CDD:290566 23/81 (28%)
leucine-rich repeat 354..375 CDD:275380 9/20 (45%)
leucine-rich repeat 376..399 CDD:275380 9/46 (20%)
LRR 15 377..396 7/42 (17%)
LRR 16 397..420 9/22 (41%)
leucine-rich repeat 400..423 CDD:275380 10/22 (45%)
LRR 17 422..444 7/21 (33%)
leucine-rich repeat 445..467 CDD:275378 8/21 (38%)
LRR 18 564..585 7/20 (35%)
7tm_1 575..820 CDD:278431 75/249 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 93 1.000 Domainoid score I7387
eggNOG 1 0.900 - - E1_KOG2087
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H20807
Inparanoid 1 1.050 380 1.000 Inparanoid score I1993
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D171884at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm45552
orthoMCL 1 0.900 - - OOG6_106088
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X2481
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1211.730

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