DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Lrguk

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_017448017.1	Gene:	Lrguk / 296968	RGDID:	1308226	Length:	1271	Species:	Rattus norvegicus

Alignment Length:	1115	Identity:	197/1115 - (17%)
Similarity:	333/1115 - (29%)	Gaps:	423/1115 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   338 ISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSM-QMLDMRA 401
            |....|.....|:.|.|..|.|..| ..:|.:..|.||:.:.|||....:.:.|::: |.:|..:
  Rat   139 IDVSILSGYVHLQKLNLSGNRIEDL-SCVSCMPYLLELNASQNRLTTFFNFKPPQNLKQKVDFSS 202

  Fly   402 NPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLK 466
            |.:|.:.                         :|.|.|.|..|.||...|:|:..  ..:...|.
  Rat   203 NQISEMY-------------------------DLSAYHTLTQLILDNNEIEEITG--LEKCISLT 240

  Fly   467 SLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQG 531
            .|.|..|.:..|..|.:. .:::|.:|:||||.|.|  ...||.|.:|.||:|:|.:|  ...:.
  Rat   241 HLSLAGNRITTIKGLGTL-PIKVLSVSNNQIETITG--LEELKALQNLDLSHNQISSL--HGLEN 300

  Fly   532 IPKLQLLDLEGNEISYIHK-EAFSGFTALEDLNLGNNIFPELPESG---LRALLHLKTFNNPKLR 592
            ...|::::||.|:|..:.: |.......|..|||..|.....||..   :..||.|...:..|::
  Rat   301 HDLLEVINLEDNKIKELSEIEYIENLPILRVLNLLRNPIQTKPEYWFFVIFMLLRLTELDQQKIK 365

  Fly   593 ---------EFPPPDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTL 648
                     ::.||......|    .:..|        .::|..:..::.::.|...||.:.|.:
  Rat   366 VEEKVYAVNKYDPPPEVVAAQ----DHMTH--------VVNSMSQPQRIFDSTLPSLDAPYPMLI 418

  Fly   649 WNNSMMNIWPQ-------MHNLSKQL------GA--SMHDPWETAINFNEEQLQTQTGGQIATSY 698
            ...      |:       .|.|.:|.      ||  :...|:     |.|       |.::...:
  Rat   419 LTG------PEACGKRELAHRLCRQFSTYFRYGACHTTRPPY-----FGE-------GDRVDYHF 465

  Fly   699 M-EEYFEEHDVSGPAT--------GYGFGTGLFSGMSTED-------------------FQPGSV 735
            : :|.|:|....|...        .||.......|::.:.                   |:|..:
  Rat   466 VSQEVFDEMLSMGKFILTFNYGNHNYGLNRDTVEGIARDGLASCIHMELEGIRSLKYSYFEPRYI 530

  Fly   736 QCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADF 800
            ..:||.      .:.::.:..|.|                   |.||:::::.      ::..|.
  Rat   531 LVVPMD------KEKYEGYLRRKG-------------------LFSRAEIEIA------VSRVDL 564

  Fly   801 FMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHA 865
            ::.:........||                         .:.:.:|.:....:..|.|.|
  Rat   565 YVKVNRKFPGYFDA-------------------------VINADDLDIAYQKLSELIREY----- 599

  Fly   866 IHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKFAVCLPFETTTG-PASLTYVISLMFI 929
                             :|........|.|..|.|..:|        |.:| ||.|.
  Rat   600 -----------------LGLTETAKKGLAPTAGASSSKK--------TVSGVPAHLV-------- 631

  Fly   930 NGCAFLTLMGCYLKMYWAIRGSQAWNTNDSRIAKRMALLVFTD-FLCWSPIAFFSITAIFGLQLI 993
                                      .:..|:|:..|....|: ||...|.|
  Rat   632 --------------------------PSPRRLARLQADGQKTEAFLEVQPHA------------- 657

  Fly   994 SLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKDCVTLCKHFEESRVVGGGGPGGRGAVARTKRG 1058
                       ::|.|.  ||.|                             |..:..   |:.|
  Rat   658 -----------MIPENQ--NPTL-----------------------------PQSQDL---TEEG 677

  Fly  1059 DLPPPLLPAAAVAHPPGCRCLRMLPSEMPNWHKMEQTPSMWQRLRTFCCGENRRRRKQRRQPQQR 1123
            :.|                             |.|.:||
  Rat   678 EAP-----------------------------KKEASPS-------------------------- 687

  Fly  1124 RQRAYTAAAANPYQYQFAELRQQRQNRASSISSEN----FCSSRSSSWRHGPPSSAPVPP---GN 1181
                            ..:|.||.|:.:..:..|:    ....:.::...| |...||||   ..
  Rat   688 ----------------HLDLPQQTQDISPKVKEEDGQPANLPPKITTETEG-PEDEPVPPVLEAG 735

  Fly  1182 CSMPLKMLEPHAHPHGHGRRRHSAWLITRKTSQDSNLSSSR--------NDSSASATTASTSTFR 1238
            .|..:...||..||       ..|..::.:..||.....::        ::.:.....||.|..|
  Rat   736 QSSTMASQEPPQHP-------APAPPLSPQLDQDKESGETKVTPNNPALSEPAQGPDPASVSPQR 793

  Fly  1239 LSRSSAGSSTPLPSIIAHN-----GKAQLDAVKPRLVRQEAVQEEEDSSPPRLGVRFLPTIPSAA 1298
            :....|.|:....|...||     ..|:::  ||.:..|.:::||...:.........|.||...
  Rat   794 VQDEGAESANLASSSSTHNLPEDPSHAEIE--KPTVGSQPSLKEETPKAEVMRASTPYPEIPPPQ 856

  Fly  1299 DSSVVMEDGDSANTGVASFLGMPLPGASSGFLIAPTTAA---TTSPPPVVLQPAK---------- 1350
            |||..:.:...|.        :|....:...|..|.|.|   :..|.|.:|.|::
  Rat   857 DSSTKVREQPVAL--------LPRSRLAPTRLPQPQTLAPLQSRRPTPKLLSPSREEALGTSSEQ 913

  Fly  1351 -PPPDPNDAP 1359
             |.|.|...|
  Rat   914 TPNPSPRSLP 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	14/44 (32%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566	6/20 (30%)
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380	2/9 (22%)
		LRR_RI	327..567	CDD:238064	62/230 (27%)
		leucine-rich repeat	349..371	CDD:275380	7/21 (33%)
		LRR_8	370..425	CDD:290566	11/55 (20%)
		leucine-rich repeat	372..393	CDD:275380	7/20 (35%)
		leucine-rich repeat	394..415	CDD:275380	4/21 (19%)
		leucine-rich repeat	418..486	CDD:275380	15/67 (22%)
		leucine-rich repeat	441..464	CDD:275378	6/22 (27%)
		LRR_8	487..545	CDD:290566	21/57 (37%)
		leucine-rich repeat	487..510	CDD:275380	9/22 (41%)
		leucine-rich repeat	511..534	CDD:275380	7/22 (32%)
		LRR_8	533..589	CDD:290566	16/59 (27%)
		leucine-rich repeat	535..558	CDD:275380	6/23 (26%)
		leucine-rich repeat	559..580	CDD:275380	7/23 (30%)
		7tm_4	764..>892	CDD:304433	11/127 (9%)
		7tm_1	770..1017	CDD:278431	33/248 (13%)
Lrguk	XP_017448017.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910