DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Lrrd1

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_216085.3	Gene:	Lrrd1 / 296836	RGDID:	1562785	Length:	855	Species:	Rattus norvegicus

Alignment Length:	791	Identity:	171/791 - (21%)
Similarity:	306/791 - (38%)	Gaps:	205/791 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PSAMGHDETKENP-------------APDMQNSQEQEPYVHLQHLQQQQQQNPQ--TVQQLSQIT 78
            |..:...|:.|.|             :|...|:...:.|      :....:|.:  :....||:.
  Rat    10 PEGLTRSESLEEPEFIDEISDPSNETSPHSGNTDFNQIY------ESNSSENTEQPSASSTSQLN 68

  Fly    79 VN-RTSKSASVTPTGIRENVMLPSADPEKEAQILYEKSLQEYH-----------GSQLSTASTAT 131
            .| .|:.....:.|.|.|.:.|.:::..:.::.......:|||           |...:......
  Rat    69 GNEETNIEIPFSDTNIEEVIPLSNSESPQSSESSETNEAEEYHPVKFPIGRKFRGRTFNGHHKGF 133

  Fly   132 DVIAGKRTLHSICERWLQ------------KHCHCTGS---------------LEVLRLSCRGIG 169
            |:.:...|:| :..:.||            |:.:...:               ||.|.|...|:.
  Rat   134 DMESDTFTVH-LDAKGLQEFPVDIVKVKYVKYLYLDKNQIKTFQGADPGDLLGLETLSLQENGLS 197

  Fly   170 ILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSL 234
            .:...:.|.:.:.||:...|.::.: ........|:.:|.|:.|.|.:: |:....|..|:.|||
  Rat   198 SIPQEIQLFHNLKVLNASYNEISHI-PKELLQLGNMRQLFLNSNHIESL-PSGLENLRYLETLSL 260

  Fly   235 QNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLR 299
            ....|..: |.|..||..|.:|.|..|.| ::....|..|.||.:|.|.||:...:| ..:..|:
  Rat   261 GKNRLTHI-PDSLCGLKNLKTLNLEYNQL-TIFSKSLCFLPKLVSLNLTGNMIGSLP-KEVRELK 322

  Fly   300 TLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPE 364
            .||.|.:..|.||.:..|.| ::..:..|.|..|::..||. .::|...|::|.||:||:.|||:
  Rat   323 NLENLLMNHNKLTFLAVEIF-QLLKIKELHLADNKLEAISP-KIENFKELRLLNLDNNLLQSLPK 385

  Fly   365 GLSKLSQLQELSITSNRLRWINDTELPRSMQML----DMRANPLSTISPG-AFRGMSKLRKLILS 424
            .:|....|:.|:::.|.|.     |||:.::.|    .:.||....|... ....:||:..|..|
  Rat   386 KISHCVNLESLTLSDNNLE-----ELPKKIRKLKNLRQLHANRNKMIKMAEEISHLSKIHSLEFS 445

  Fly   425 ---------DVRTLRSFPELE--------------ACHALEILKLDRAGIQEVPA---------- 456
                     :::..:....:|              |..:|:.|..:...|.|:|.
  Rat   446 GNQITHVPIEIKNCKEITRVELNYNNIMYFPVGLCALQSLDYLSFNGNYISEIPVDLSFSKQLLH 510

  Fly   457 -------------NLCRQTPRLKSLELKTNSLKRIPN------------------------LSSC 484
                         :||..| .|:.|:|..|.:::||:                        |.|.
  Rat   511 LELNKNKITIFSEHLCSLT-NLEYLDLAKNQIRKIPHCISAMLSLHVLILSDNKFEIFPKELCSL 574

  Fly   485 RDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQD--AFQGIPKLQLLDLEGNEISY 547
            ::|:|||:|.||:.||..: .:.||::..|.||.|.....|.:  ..|.:..|.:..:.|.:::.
  Rat   575 KNLQLLDISENQLHKIPSE-ISKLKKIQKLNLSNNNFTHFPAELCQLQTLEDLNISQISGKKLTR 638

  Fly   548 IHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTF--NNPKLREFPPPDTFPRIQTLILSY 610
            :.:|. |..|.|:.||:.||...|:|.: :..|.:|.||  :|.::...|
  Rat   639 LPEEV-SRMTQLKALNISNNAIKEIPRN-IGELRNLITFHASNNQINSLP--------------- 686

  Fly   611 AYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPW 675
                .:||.|..:.|                    :.|..|::.::...::.||     |:.:
  Rat   687 ----SSFLSLNVLQS--------------------LDLGGNNLTDLPSAIYKLS-----SLKE-- 720

  Fly   676 ETAINFNEEQL 686
               |||::..|
  Rat   721 ---INFDDNPL 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	6/20 (30%)
		LRR_RI	180..>383	CDD:238064	61/202 (30%)
		leucine-rich repeat	183..204	CDD:275380	3/20 (15%)
		LRR_8	203..263	CDD:290566	20/59 (34%)
		leucine-rich repeat	205..228	CDD:275380	6/22 (27%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		LRR_8	252..311	CDD:290566	19/58 (33%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		LRR_8	299..359	CDD:290566	19/59 (32%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..348	CDD:275380	6/22 (27%)
		LRR_RI	327..567	CDD:238064	74/316 (23%)
		leucine-rich repeat	349..371	CDD:275380	10/21 (48%)
		LRR_8	370..425	CDD:290566	15/68 (22%)
		leucine-rich repeat	372..393	CDD:275380	7/20 (35%)
		leucine-rich repeat	394..415	CDD:275380	4/25 (16%)
		leucine-rich repeat	418..486	CDD:275380	20/137 (15%)
		leucine-rich repeat	441..464	CDD:275378	8/45 (18%)
		LRR_8	487..545	CDD:290566	19/59 (32%)
		leucine-rich repeat	487..510	CDD:275380	10/22 (45%)
		leucine-rich repeat	511..534	CDD:275380	6/24 (25%)
		LRR_8	533..589	CDD:290566	16/57 (28%)
		leucine-rich repeat	535..558	CDD:275380	4/22 (18%)
		leucine-rich repeat	559..580	CDD:275380	7/20 (35%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Lrrd1	XP_216085.3	leucine-rich repeat	162..185	CDD:275380	1/22 (5%)
		LRR_8	185..242	CDD:290566	13/57 (23%)
		leucine-rich repeat	186..208	CDD:275380	6/21 (29%)
		leucine-rich repeat	209..231	CDD:275380	3/22 (14%)
		leucine-rich repeat	232..254	CDD:275380	6/22 (27%)
		LRR_RI	253..564	CDD:238064	79/321 (25%)
		LRR_8	253..311	CDD:290566	22/59 (37%)
		leucine-rich repeat	255..277	CDD:275380	9/22 (41%)
		leucine-rich repeat	278..300	CDD:275380	7/22 (32%)
		LRR_8	299..357	CDD:290566	19/59 (32%)
		leucine-rich repeat	301..323	CDD:275380	7/22 (32%)
		leucine-rich repeat	324..346	CDD:275380	8/22 (36%)
		leucine-rich repeat	347..392	CDD:275380	16/45 (36%)
		leucine-rich repeat	439..461	CDD:275380	2/21 (10%)
		leucine-rich repeat	463..484	CDD:275380	2/20 (10%)
		leucine-rich repeat	487..507	CDD:275380	4/19 (21%)
		leucine-rich repeat	508..530	CDD:275380	3/22 (14%)
		leucine-rich repeat	531..553	CDD:275380	6/21 (29%)
		LRR_RI	537..>728	CDD:238064	52/242 (21%)
		LRR_8	553..610	CDD:290566	17/57 (30%)
		leucine-rich repeat	554..576	CDD:275380	2/21 (10%)
		leucine-rich repeat	577..599	CDD:275380	10/22 (45%)
		leucine-rich repeat	600..648	CDD:275380	10/48 (21%)
		leucine-rich repeat	649..671	CDD:275380	8/22 (36%)
		LRR_8	670..728	CDD:290566	17/106 (16%)
		leucine-rich repeat	672..694	CDD:275380	8/40 (20%)
		leucine-rich repeat	695..717	CDD:275380	5/46 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910