DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Cd180

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001099875.1	Gene:	Cd180 / 294706	RGDID:	1308170	Length:	662	Species:	Rattus norvegicus

Alignment Length:	632	Identity:	155/632 - (24%)
Similarity:	252/632 - (39%)	Gaps:	162/632 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 SCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPN------------------------ 204
            :|..:|:..:|..|||....|:...|.|..::..:|....|
  Rat    38 NCEHLGLSEIPGTLPNSTESLEFSFNALPTIQKTTFSRLVNLTFLDLTRCQIYWIHEDTFQSQHR 102

  Fly   205 LEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGD 269
            ||.|.|:.|.:|.|...|..|...||.|.....|:.|:..........|.||.|..|.:.|:...
  Rat   103 LETLVLTANPLIFMAETALTGPKALKHLFFIQTGISSIEFIPVHSQKALESLYLGSNHISSIRLP 167

  Fly   270 CLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNL--------------LTIINDEDFP 320
            .....:||:.|..:.|..:.:....::.|:  :|.||..||              .|:....:|.
  Rat   168 KDFPTEKLKVLDFQNNAIHHLSKEDVSSLQ--QATNLSLNLNGNDITGIEPGAFKSTVFQSLNFG 230

  Fly   321 RMPNLIVLL--LKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLS----QLQE---LS 376
            ...:|:|:.  |:.:.|..:..|..::      ::.|:::.||:.|||.::|    .||:   .:
  Rat   231 GTQSLLVIFKGLQNSTIQSLWLGTFED------IDDDEDISSSMFEGLCEMSVERINLQKHHFFN 289

  Fly   377 ITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHAL 441
            ||||.....:      .:|.||:.|..|:.: |....|:|||:||:||             .:..
  Rat   290 ITSNTFYCFS------GLQELDLTATHLTEL-PSGIVGLSKLKKLVLS-------------ANKF 334

  Fly   442 EILKLDRAGIQEVPANLCR----QTPRLKSLELKTNSLKRIPNLSSCRD----LRLLDLSSNQIE 498
            |              |||:    ..|.|..|.:|.|: ||:...|.|.:    ||.||||.:.||
  Rat   335 E--------------NLCQISASNFPSLTHLYIKGNT-KRLELGSGCLETLEHLRELDLSHDDIE 384

  Fly   499 -----KIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIH-KEA---FS 554
                 .:|.:..:.|:.||   ||||....|..:||:..|:|:||||   ..:.:| |:|   |.
  Rat   385 TSDCCNLQLRNLSHLQSLN---LSYNEPLGLRTEAFKECPQLELLDL---AFTRLHVKDAQSPFQ 443

  Fly   555 GFTALEDLNLGNNIFPELPE---SGLRALLHL----KTFNNPKLREFPPPDTFPRIQTLILSYAY 612
            ....|:.|||.:.:.....:   .||.||.||    ..|.|..:::..|......::.||||:
  Rat   444 NLHLLKVLNLSHCLLGSSNQHLLDGLPALRHLNLQGNRFPNGNIQKTNPLQALGSLEILILSF-- 506

  Fly   613 HCC--------AFLPL-----VAMSSQKKTSQVQEAV-----LFPSDAEFDMTLWNNSMMNIWPQ 659
              |        ||:.|     |.:|..:.||...||:     ::       :.|.:|.:..|.|.
  Rat   507 --CDLSSIDHQAFINLKIMNHVDLSHNRLTSSSIEALSHLKGIY-------LNLASNRISIIPPS 562

  Fly   660 MHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEH 706
            :..:..|         :..||..:..|..    ..:..|..|:::|:
  Rat   563 LLPVLSQ---------QRTINLRQNPLDC----TCSNIYFLEWYKEN 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	4/14 (29%)
		LRR_RI	180..>383	CDD:238064	55/249 (22%)
		leucine-rich repeat	183..204	CDD:275380	4/20 (20%)
		LRR_8	203..263	CDD:290566	20/83 (24%)
		leucine-rich repeat	205..228	CDD:275380	9/22 (41%)
		leucine-rich repeat	229..252	CDD:275380	5/22 (23%)
		LRR_8	252..311	CDD:290566	16/72 (22%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	4/22 (18%)
		LRR_8	299..359	CDD:290566	13/75 (17%)
		leucine-rich repeat	301..324	CDD:275380	7/36 (19%)
		leucine-rich repeat	325..348	CDD:275380	5/24 (21%)
		LRR_RI	327..567	CDD:238064	77/265 (29%)
		leucine-rich repeat	349..371	CDD:275380	7/25 (28%)
		LRR_8	370..425	CDD:290566	20/61 (33%)
		leucine-rich repeat	372..393	CDD:275380	6/23 (26%)
		leucine-rich repeat	394..415	CDD:275380	6/20 (30%)
		leucine-rich repeat	418..486	CDD:275380	18/71 (25%)
		leucine-rich repeat	441..464	CDD:275378	4/26 (15%)
		LRR_8	487..545	CDD:290566	25/62 (40%)
		leucine-rich repeat	487..510	CDD:275380	10/27 (37%)
		leucine-rich repeat	511..534	CDD:275380	9/22 (41%)
		LRR_8	533..589	CDD:290566	21/66 (32%)
		leucine-rich repeat	535..558	CDD:275380	9/26 (35%)
		leucine-rich repeat	559..580	CDD:275380	6/23 (26%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Cd180	NP_001099875.1	leucine-rich repeat	55..78	CDD:275380	4/22 (18%)
		leucine-rich repeat	79..102	CDD:275380	0/22 (0%)
		leucine-rich repeat	103..126	CDD:275380	9/22 (41%)
		leucine-rich repeat	127..150	CDD:275380	5/22 (23%)
		leucine-rich repeat	151..174	CDD:275380	6/22 (27%)
		leucine-rich repeat	175..195	CDD:275380	3/19 (16%)
		leucine-rich repeat	196..223	CDD:275380	6/28 (21%)
		leucine-rich repeat	224..244	CDD:275380	4/19 (21%)
		leucine-rich repeat	277..300	CDD:275380	6/28 (21%)
		LRR_RI	301..480	CDD:238064	66/213 (31%)
		leucine-rich repeat	301..323	CDD:275380	7/22 (32%)
		LRR_8	322..383	CDD:290566	26/88 (30%)
		leucine-rich repeat	324..347	CDD:275380	9/49 (18%)
		leucine-rich repeat	348..372	CDD:275380	8/24 (33%)
		LRR_8	372..433	CDD:290566	25/66 (38%)
		leucine-rich repeat	373..398	CDD:275380	9/24 (38%)
		leucine-rich repeat	399..422	CDD:275380	10/25 (40%)
		LRR_8	421..482	CDD:290566	20/63 (32%)
		leucine-rich repeat	423..447	CDD:275380	9/26 (35%)
		leucine-rich repeat	448..471	CDD:275380	6/22 (27%)
		leucine-rich repeat	472..498	CDD:275380	6/25 (24%)
		LRR_8	498..556	CDD:290566	16/68 (24%)
		leucine-rich repeat	499..522	CDD:275380	8/26 (31%)
		leucine-rich repeat	523..546	CDD:275380	6/22 (27%)
		TPKR_C2	578..627	CDD:301599	4/23 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910