DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Lrrtm3

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001099857.1	Gene:	Lrrtm3 / 294380	RGDID:	1304866	Length:	582	Species:	Rattus norvegicus

Alignment Length:	419	Identity:	114/419 - (27%)
Similarity:	183/419 - (43%)	Gaps:	48/419 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 GSQLSTASTATDVIAGKRTLHSICERWLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLD 185
            ||.::.....|.::    |:.|..||...|.|.|.|.:    :.|....:..:|.::....:.|.
  Rat    11 GSAVAVVLAPTVLL----TMLSSAERGCPKGCRCEGKM----VYCESQKLQEIPSSISAGCLGLS 67

  Fly   186 LGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGL 250
            |..|:|.||:.|.|.....|..|.|..|.|.|:|.|||.|:.:||.|.|.:..:......:|:.:
  Rat    68 LRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPV 132

  Fly   251 AQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIIN 315
            ..|.:|.|:.|.|.||..:....|:||.:|.|..|....||.......|.||.|:||.|.:..:.
  Rat   133 TNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLA 197

  Fly   316 DEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSN 380
            ...|..|..|..|.|:.||..|::......|.:|:.|.:..|.||.:.:.:|
  Rat   198 RNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYMQWNKISVIGQTMS------------- 249

  Fly   381 RLRWINDTELPRSMQMLDMRANPLSTIS-PGAFRGMSKLRKLIL-SDVRTLRSFPELEACHALEI 443
             ..|       .|:|.||:..|.:...| |..|:.:..|::|.| |:..|......|::..:|..
  Rat   250 -WTW-------SSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLND 306

  Fly   444 LKLDRAG-IQEVPANLCRQTPRLKSLE-LKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFN 506
            :.|  || |.|...|:|.....|||.: |:.|::.    .:|.::|:    ..|.|:.::.....
  Rat   307 ISL--AGNIWECSRNICSLVNWLKSFKGLRENTIL----CASPKELQ----GVNVIDAVKNYSIC 361

  Fly   507 GLKQLNDLLLSYNRIKALPQDAFQGIPKL 535
            |.....:   .::..:|||:..|:  |||
  Rat   362 GKSTTTE---RFDLARALPKPTFK--PKL 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	2/20 (10%)
		LRR_RI	180..>383	CDD:238064	61/202 (30%)
		leucine-rich repeat	183..204	CDD:275380	8/20 (40%)
		LRR_8	203..263	CDD:290566	20/59 (34%)
		leucine-rich repeat	205..228	CDD:275380	11/22 (50%)
		leucine-rich repeat	229..252	CDD:275380	5/22 (23%)
		LRR_8	252..311	CDD:290566	22/58 (38%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		LRR_8	299..359	CDD:290566	19/59 (32%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		LRR_RI	327..567	CDD:238064	52/213 (24%)
		leucine-rich repeat	349..371	CDD:275380	6/21 (29%)
		LRR_8	370..425	CDD:290566	12/56 (21%)
		leucine-rich repeat	372..393	CDD:275380	1/20 (5%)
		leucine-rich repeat	394..415	CDD:275380	7/21 (33%)
		leucine-rich repeat	418..486	CDD:275380	20/70 (29%)
		leucine-rich repeat	441..464	CDD:275378	8/23 (35%)
		LRR_8	487..545	CDD:290566	11/49 (22%)
		leucine-rich repeat	487..510	CDD:275380	4/22 (18%)
		leucine-rich repeat	511..534	CDD:275380	4/22 (18%)
		LRR_8	533..589	CDD:290566	3/3 (100%)
		leucine-rich repeat	535..558	CDD:275380	1/1 (100%)
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Lrrtm3	NP_001099857.1	LRRNT	33..61	CDD:214470	6/31 (19%)
		LRR 1	61..83		8/21 (38%)
		leucine-rich repeat	66..86	CDD:275380	8/19 (42%)
		LRR_RI	<81..300	CDD:238064	69/239 (29%)
		LRR 2	84..107		10/22 (45%)
		LRR_8	86..145	CDD:290566	20/58 (34%)
		leucine-rich repeat	87..110	CDD:275380	11/22 (50%)
		LRR 3	109..131		5/21 (24%)
		leucine-rich repeat	111..134	CDD:275380	5/22 (23%)
		LRR 4	132..155		7/22 (32%)
		LRR_8	133..193	CDD:290566	22/59 (37%)
		leucine-rich repeat	135..158	CDD:275380	8/22 (36%)
		LRR 5	156..179		8/22 (36%)
		leucine-rich repeat	159..182	CDD:275380	6/22 (27%)
		LRR_8	181..241	CDD:290566	19/59 (32%)
		LRR 6	181..203		8/21 (38%)
		leucine-rich repeat	183..206	CDD:275380	8/22 (36%)
		LRR 7	205..227		6/21 (29%)
		leucine-rich repeat	207..230	CDD:275380	7/22 (32%)
		LRR 8	229..251		6/35 (17%)
		LRR_8	230..290	CDD:290566	19/80 (24%)
		leucine-rich repeat	231..254	CDD:275380	7/43 (16%)
		LRR 9	252..276		9/30 (30%)
		leucine-rich repeat	255..279	CDD:275380	7/23 (30%)
		LRR 10	277..300		6/22 (27%)
		leucine-rich repeat	280..300	CDD:275380	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..411		4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910