DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Npy1r

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001106828.1	Gene:	Npy1r / 29358	RGDID:	3198	Length:	382	Species:	Rattus norvegicus

Alignment Length:	320	Identity:	72/320 - (22%)
Similarity:	140/320 - (43%)	Gaps:	61/320 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   745 LPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGI----Y 805
            ||.|.:|   ||......|.:|.:.||..::.::|..:...:|...|:.||:.:|..:.:    :
  Rat    34 LPLAVIF---TLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAVMCLPF 95

  Fly   806 LGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNK 870
            ..:..::|....||           .:|:|:.|:..:|..:|:::|.:|.:||     |.:.:|.
  Rat    96 TFVYTLMDHWVFGE-----------TMCKLNPFVQCVSITVSIFSLVLIAVER-----HQLIINP 144

  Fly   871 R--LSLKQAGYI-MSVGWVFALIMALMPL-------------VGVSDYRKFAVCL-PFETTTGPA 918
            |  ....:..|| ::|.||.|:..:| |.             |.::.::...||. .|.:.:...
  Rat   145 RGWRPNNRHAYIGITVIWVLAVASSL-PFVIYQILTDEPFQNVSLAAFKDKYVCFDKFPSDSHRL 208

  Fly   919 S-LTYVISLMFINGCAFLTLMGCYLKMYW----------AIRGSQAWNTNDSRIAKRMALLVFTD 972
            | .|.::.|.:.....|:.:  ||.|:|.          .||.|:..::...||...:..:|...
  Rat   209 SYTTLLLVLQYFGPLCFIFI--CYFKIYVRLKRRNNMMDKIRDSKYRSSETKRINVMLLSIVVAF 271

  Fly   973 FLCWSPIAFFSITAIFGLQLISLEQAKIFTVFVL-----PLNSCCNPFLYAIMTKQFKKD 1027
            .:||.|:..|:....:..|:|:.....:  :|:|     .:::|.||..|..:.|.|::|
  Rat   272 AVCWLPLTIFNTVFDWNHQIIATCNHNL--LFLLCHLTAMISTCVNPIFYGFLNKNFQRD 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	30/134 (22%)
		7tm_1	770..1017	CDD:278431	60/283 (21%)
Npy1r	NP_001106828.1	7tmA_NPY1R	40..330	CDD:320517	69/314 (22%)
		TM helix 1	42..66	CDD:320517	5/23 (22%)
		TM helix 2	75..97	CDD:320517	4/21 (19%)
		TM helix 3	113..135	CDD:320517	6/21 (29%)
		TM helix 4	156..172	CDD:320517	6/16 (38%)
		TM helix 5	208..231	CDD:320517	5/24 (21%)
		TM helix 6	261..283	CDD:320517	5/21 (24%)
		TM helix 7	298..323	CDD:320517	6/26 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910