DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Lrrc32

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_006229808.1	Gene:	Lrrc32 / 293135	RGDID:	1309087	Length:	690	Species:	Rattus norvegicus

Alignment Length:	477	Identity:	151/477 - (31%)
Similarity:	214/477 - (44%)	Gaps:	40/477 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 SICERWLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEAN--SFFMAPN 204
            :|.:|..|..|. |.:.|.|   |.|:.:|.||..|..::..|.|..|.|..:..:  ||:.|
  Rat    44 AISQRRDQVPCR-TVNKEAL---CHGLSLLQVPSVLSLDIQALYLSGNRLQSILVSPLSFYTA-- 102

  Fly   205 LEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQL---TSLQLNGNAL-VS 265
            |..|.||||.|..:.|..|..|..|:.|:|.:..|.:....:..||.:|   .||.|:||:| .|
  Rat   103 LRHLDLSDNEISFLQPGVFQALPYLEHLNLAHNRLAAGMALNSGGLGRLPLVVSLDLSGNSLHGS 167

  Fly   266 LDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLL 330
            |....||...:||||.|..|...|:..:...|:..:|.|:|.||:|..|.|..|..:|.|..|.|
  Rat   168 LVERLLGEAPRLRTLSLAENSLTRLARHTFWGMPAMEQLDLHSNVLMDIEDGAFEALPQLTHLNL 232

  Fly   331 KRNQIMKISAGALKNLTALKVLELDDNLISSL---PEGLSKLSQLQELSITSNRLRWINDTELPR 392
            .||.:..||..:|:.   |:||:|..|.|.:.   ||..::. ||..|.:..|:|....|..:..
  Rat   233 SRNSLTCISDFSLQQ---LQVLDLSCNSIETFQTAPESQAQF-QLAWLDLRENKLLHFPDLAMFP 293

  Fly   393 SMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEA-CHAL-EILKLDRA--GIQE 453
            .:..|:: :|.|..:..|..:....|.........:|.|.|...| .|.| ::|.||.:  .|:.
  Rat   294 RLIYLNV-SNNLIQLPTGLPQDSEDLHAPSEGWSASLLSNPSRNASIHPLSQLLNLDLSYNEIEL 357

  Fly   454 VPANLCRQTPRLKSLELKTNSLKRIP--NLSSCRDLRLLDLSSNQIEKIQ-GKPFNGLKQLNDLL 515
            |||........|:.|.|..|.|:...  ...|...|.|||||.|.:|.:: |....|  .|..||
  Rat   358 VPAGFLEHLTSLRFLNLSRNCLRSFEARRAGSLPCLVLLDLSHNVLEALELGTKVLG--SLKTLL 420

  Fly   516 LSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEA---------FSGFTALEDLNLGNNIFPE 571
            |..|.::.||...|.|:..||.|:|:||::|....:|         |||...|..||:..|....
  Rat   421 LQDNTLRELPPYTFAGLASLQRLNLQGNQVSPCGGQAEPGPPGCVDFSGIPTLHFLNMAGNSMET 485

  Fly   572 LPESGL--RALLHLKTFNNPKL 591
            |.....  ..|..|....||.|
  Rat   486 LRAGSFLHTPLTELDLSANPGL 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	8/20 (40%)
		LRR_RI	180..>383	CDD:238064	72/211 (34%)
		leucine-rich repeat	183..204	CDD:275380	7/22 (32%)
		LRR_8	203..263	CDD:290566	22/62 (35%)
		leucine-rich repeat	205..228	CDD:275380	10/22 (45%)
		leucine-rich repeat	229..252	CDD:275380	6/22 (27%)
		LRR_8	252..311	CDD:290566	24/62 (39%)
		leucine-rich repeat	253..276	CDD:275380	11/26 (42%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		LRR_8	299..359	CDD:290566	23/59 (39%)
		leucine-rich repeat	301..324	CDD:275380	9/22 (41%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		LRR_RI	327..567	CDD:238064	78/258 (30%)
		leucine-rich repeat	349..371	CDD:275380	8/24 (33%)
		LRR_8	370..425	CDD:290566	11/54 (20%)
		leucine-rich repeat	372..393	CDD:275380	5/20 (25%)
		leucine-rich repeat	394..415	CDD:275380	4/20 (20%)
		leucine-rich repeat	418..486	CDD:275380	20/73 (27%)
		leucine-rich repeat	441..464	CDD:275378	8/25 (32%)
		LRR_8	487..545	CDD:290566	25/58 (43%)
		leucine-rich repeat	487..510	CDD:275380	10/23 (43%)
		leucine-rich repeat	511..534	CDD:275380	9/22 (41%)
		LRR_8	533..589	CDD:290566	18/66 (27%)
		leucine-rich repeat	535..558	CDD:275380	11/31 (35%)
		leucine-rich repeat	559..580	CDD:275380	5/22 (23%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Lrrc32	XP_006229808.1	LRR_8	80..137	CDD:290566	20/58 (34%)
		LRR_RI	82..305	CDD:238064	76/229 (33%)
		leucine-rich repeat	82..102	CDD:275380	6/19 (32%)
		leucine-rich repeat	103..126	CDD:275380	10/22 (45%)
		leucine-rich repeat	127..153	CDD:275380	7/25 (28%)
		leucine-rich repeat	154..178	CDD:275380	10/23 (43%)
		LRR_8	177..237	CDD:290566	23/59 (39%)
		leucine-rich repeat	179..202	CDD:275380	8/22 (36%)
		leucine-rich repeat	203..226	CDD:275380	9/22 (41%)
		LRR_8	225..283	CDD:290566	21/61 (34%)
		leucine-rich repeat	227..247	CDD:275380	8/19 (42%)
		leucine-rich repeat	248..272	CDD:275380	8/24 (33%)
		leucine-rich repeat	273..294	CDD:275380	5/20 (25%)
		LRR_8	343..403	CDD:290566	20/59 (34%)
		leucine-rich repeat	345..368	CDD:275380	7/22 (32%)
		LRR_RI	389..605	CDD:238064	41/121 (34%)
		LRR_8	393..450	CDD:290566	25/58 (43%)
		leucine-rich repeat	393..415	CDD:275380	10/23 (43%)
		leucine-rich repeat	416..439	CDD:275380	9/22 (41%)
		leucine-rich repeat	440..472	CDD:275380	11/31 (35%)
		leucine-rich repeat	473..494	CDD:275380	5/20 (25%)
		leucine-rich repeat	496..520	CDD:275380	5/12 (42%)
		leucine-rich repeat	521..543	CDD:275380
		LRR_8	542..601	CDD:290566
		leucine-rich repeat	544..565	CDD:275380
		leucine-rich repeat	566..587	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910