DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rk and Tlr4

DIOPT Version :9

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:NP_062051.2 Gene:Tlr4 / 29260 RGDID:3870 Length:835 Species:Rattus norvegicus


Alignment Length:887 Identity:197/887 - (22%)
Similarity:315/887 - (35%) Gaps:294/887 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   152 CHCTGSL----EVL---RLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELT 209
            |...|||    |||   ...|....:..:|.::|.....|||..|.|..|.:.||.....|:.|.
  Rat    19 CLRPGSLNPCIEVLPNITYQCMDQNLSKIPHDIPYSTKNLDLSFNPLKILRSYSFSNFSQLQWLD 83

  Fly   210 LSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHL 274
            ||...|..::..|::||.:|..|.|....:||..|.||.||..|.:|......:.||:|..:|.|
  Rat    84 LSRCEIETIEDKAWHGLNQLSTLVLTGNPIKSFSPGSFSGLTNLENLVAVETKMTSLEGFHIGQL 148

  Fly   275 QKLRTLRLEGNLF--YRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRM---PNL-IVLLLKRN 333
            ..|:.|.:..||.  :::| ...:.|..||.::|..|.:..|:.:|...:   |.: :.|.|..|
  Rat   149 ISLKKLNVAHNLIHSFKLP-EYFSNLTNLEHVDLSYNYIQTISVKDLQFLRENPQVNLSLDLSLN 212

  Fly   334 QIMKISAGA------------------------LKNLTALKVLEL-------DDNLIS---SLPE 364
            .|..|.|.|                        |:|:|.|.|..|       :.||.|   |:.|
  Rat   213 PIDSIQAQAFQGIRLHELTLRSNFNSSNVLKMCLQNMTGLHVHRLILGEFKNERNLESFDRSVME 277

  Fly   365 GLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRGM---------SKLRK 420
            ||.      .:||...||.:||..    |..:.::  |.|:.||..:|.|:         ...:.
  Rat   278 GLC------NVSIDEFRLTYINHF----SDDIYNL--NCLANISAMSFTGVHIKHIADVPRHFKW 330

  Fly   421 LILSDVRT-LRSFPELEACHALEILK-----LDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIP 479
            ..||.:|. |:.||:|    :|..||     .:|..|......|    |.|:.|:|..|::    
  Rat   331 QSLSIIRCHLKPFPKL----SLPFLKSWTLTTNREDISFGQLAL----PSLRYLDLSRNAM---- 383

  Fly   480 NLSSC--------RDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQ-DAFQGIPKL 535
            :...|        .:|:.||||.|.: .:....|.||::|..|...::.:|.:.: ..|..:.||
  Rat   384 SFRGCCSYSDFGTNNLKYLDLSFNGV-ILMSANFMGLEELEYLDFQHSTLKKVTEFSVFLSLEKL 447

  Fly   536 QLLDLEGNEISYIHKE-----AFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFP 595
            ..||     |||.:.:     .|.|..:|..|.:..|.|.:            .|.:|       
  Rat   448 LYLD-----ISYTNTKIDFDGIFLGLISLNTLKMAGNSFKD------------NTLSN------- 488

  Fly   596 PPDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNI---- 656
               .|.....|         .||.|    |:.:..|:...|.   |..:.:.|.|.|..|:    
  Rat   489 ---VFTNTTNL---------TFLDL----SKCQLEQISRGVF---DTLYRLQLLNMSHNNLLFLD 534

  Fly   657 ---WPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFG 718
               :.|:::| :.|..|          ||  :::|..|       :.::|.:             
  Rat   535 PSHYKQLYSL-RTLDCS----------FN--RIETSKG-------ILQHFPK------------- 566

  Fly   719 TGLFSGMSTEDFQPGSVQCLPMPGPFL----------------PCAD--------LFDWWTLRCG 759
                 .::..:....||.|:.....||                .||.        :.|:....|.
  Rat   567 -----SLAVFNLTNNSVACICEYQNFLQWVKDQKMFLVNVEQMKCASPIDMKASLVLDFTNSTCY 626

  Fly   760 VW----VVFLLSLLGNGTVVFVL----------------------------------------LC 780
            ::    .|.::|:|...||.|::                                        |.
  Rat   627 IYKTIISVSVVSVLVVATVAFLIYHFYFHLILIAGCKKYSRGESIYDAFVIYSSQNEDWVRNELV 691

  Fly   781 SRSKMDVPRFLVCNLAAADFFMGIYLG-------------ILAIVDAA------TLGEFRMFAIP 826
            ...:..||||.:| |...||..|:.:.             ::.:|...      .:.|:.: |..
  Rat   692 KNLEEGVPRFQLC-LHYRDFIPGVAIAANIIQEGFHKSRKVIVVVSRHFIQSRWCIFEYEI-AQT 754

  Fly   827 WQMSVLCQLSGFL---------AVLSSELSVYTLAVITLERN 859
            ||.  |...||.:         ::|..::.:|.|    |.||
  Rat   755 WQF--LSSRSGIIFIVLEKVEKSLLRQQVELYRL----LSRN 790

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380 6/27 (22%)
LRR_RI 180..>383 CDD:238064 69/242 (29%)
leucine-rich repeat 183..204 CDD:275380 8/20 (40%)
LRR_8 203..263 CDD:290566 20/59 (34%)
leucine-rich repeat 205..228 CDD:275380 8/22 (36%)
leucine-rich repeat 229..252 CDD:275380 10/22 (45%)
LRR_8 252..311 CDD:290566 17/60 (28%)
leucine-rich repeat 253..276 CDD:275380 7/22 (32%)
leucine-rich repeat 277..300 CDD:275380 6/24 (25%)
LRR_8 299..359 CDD:290566 21/94 (22%)
leucine-rich repeat 301..324 CDD:275380 6/25 (24%)
leucine-rich repeat 325..348 CDD:275380 9/47 (19%)
LRR_RI 327..567 CDD:238064 76/302 (25%)
leucine-rich repeat 349..371 CDD:275380 10/31 (32%)
LRR_8 370..425 CDD:290566 14/63 (22%)
leucine-rich repeat 372..393 CDD:275380 6/20 (30%)
leucine-rich repeat 394..415 CDD:275380 5/20 (25%)
leucine-rich repeat 418..486 CDD:275380 19/81 (23%)
leucine-rich repeat 441..464 CDD:275378 6/27 (22%)
LRR_8 487..545 CDD:290566 17/58 (29%)
leucine-rich repeat 487..510 CDD:275380 9/22 (41%)
leucine-rich repeat 511..534 CDD:275380 4/23 (17%)
LRR_8 533..589 CDD:290566 14/60 (23%)
leucine-rich repeat 535..558 CDD:275380 8/27 (30%)
leucine-rich repeat 559..580 CDD:275380 4/20 (20%)
7tm_4 764..>892 CDD:304433 29/164 (18%)
7tm_1 770..1017 CDD:278431 27/158 (17%)
Tlr4NP_062051.2 PLN00113 23..>456 CDD:215061 127/463 (27%)
LRR 1 54..75 8/20 (40%)
leucine-rich repeat 58..78 CDD:275380 8/19 (42%)
LRR 2 78..99 6/20 (30%)
leucine-rich repeat 79..102 CDD:275380 8/22 (36%)
LRR 3 102..123 8/20 (40%)
leucine-rich repeat 103..126 CDD:275380 10/22 (45%)
LRR 4 126..147 5/20 (25%)
leucine-rich repeat 127..150 CDD:275380 7/22 (32%)
LRR 5 150..171 5/21 (24%)
leucine-rich repeat 151..175 CDD:275380 6/24 (25%)
LRR 6 175..198 6/22 (27%)
leucine-rich repeat 176..204 CDD:275380 7/27 (26%)
LRR 7 204..224 7/19 (37%)
leucine-rich repeat 205..226 CDD:275380 7/20 (35%)
LRR 8 226..247 0/20 (0%)
leucine-rich repeat 256..310 CDD:275380 18/65 (28%)
LRR 9 372..381 3/8 (38%)
leucine-rich repeat 373..398 CDD:275380 5/28 (18%)
LRR 10 398..420 8/22 (36%)
leucine-rich repeat 399..421 CDD:275380 9/22 (41%)
LRR 11 421..442 3/20 (15%)
leucine-rich repeat 422..446 CDD:275380 4/23 (17%)
LRR 12 446..467 8/25 (32%)
leucine-rich repeat 447..470 CDD:275380 8/27 (30%)
LRR 13 470..491 6/42 (14%)
leucine-rich repeat 471..495 CDD:275380 7/45 (16%)
LRR_8 494..554 CDD:404697 18/88 (20%)
LRR 14 495..516 7/36 (19%)
leucine-rich repeat 496..519 CDD:275380 8/38 (21%)
LRR 15 519..540 4/20 (20%)
leucine-rich repeat 520..543 CDD:275380 5/22 (23%)
LRR 16 543..564 7/40 (18%)
leucine-rich repeat 544..567 CDD:275380 8/60 (13%)
TIR 672..813 CDD:214587 24/127 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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