DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Drc3

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001013879.1	Gene:	Drc3 / 287371	RGDID:	1309150	Length:	523	Species:	Rattus norvegicus

Alignment Length:	359	Identity:	87/359 - (24%)
Similarity:	132/359 - (36%)	Gaps:	122/359 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   415 MSKLRKLILSDVRTLR-SFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRI 478
            ::|...::..||..|: .|.        .||::|         ||. |...|:.|:|..|.::||
  Rat    34 LAKQEGILFKDVLALQLDFQ--------NILRID---------NLW-QFENLRKLQLNNNIIERI 80

  Fly   479 PNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGN 543
            ..|.:...|..||||.|.||.|:|  .:.|..|.||.||:|||..:  |:...:..||:|.|..|
  Rat    81 EGLENLTHLVWLDLSFNNIEAIEG--LDTLVNLEDLSLSHNRISKI--DSLDPLVNLQVLSLGNN 141

  Fly   544 EISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFPRIQTLIL 608
            :|:                |:.|.|:                     ||.      ||.::||.|
  Rat   142 QIN----------------NMMNIIY---------------------LRR------FPCLRTLSL 163

  Fly   609 S---------YAYHCCAFLP-LVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNL 663
            |         |.....|:|| ||.:..::...|.:|..........|......::|.
  Rat   164 SGNPVSEAEEYKVFIYAYLPDLVYLDFRRVDEQAREVAKMKHQYSIDELKHREALMQ-------- 220

  Fly   664 SKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTE 728
                           |...|||.:.|   ::|...|.  |.|| ::||.        ||..|.::
  Rat   221 ---------------IRLEEEQAKQQ---KLAEHKMA--FVEH-LNGPF--------LFDSMYSD 256

  Fly   729 DFQPGSVQCLPMPGPFLP---------CADLFDW 753
            |.:...:..||..|..|.         |.::|::
  Rat   257 DVEGNKLSYLPGVGELLEAYKDKFVIICLNIFEY 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064	45/152 (30%)
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566	1/9 (11%)
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380	87/359 (24%)
		leucine-rich repeat	418..486	CDD:275380	17/68 (25%)
		leucine-rich repeat	441..464	CDD:275378	6/22 (27%)
		LRR_8	487..545	CDD:290566	25/57 (44%)
		leucine-rich repeat	487..510	CDD:275380	11/22 (50%)
		leucine-rich repeat	511..534	CDD:275380	9/22 (41%)
		LRR_8	533..589	CDD:290566	9/55 (16%)
		leucine-rich repeat	535..558	CDD:275380	6/22 (27%)
		leucine-rich repeat	559..580	CDD:275380	3/20 (15%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Drc3	NP_001013879.1	LRR 1	44..65		10/38 (26%)
		leucine-rich repeat	48..66	CDD:275378	8/35 (23%)
		LRR_4	65..105	CDD:289563	17/41 (41%)
		LRR_8	66..121	CDD:290566	24/56 (43%)
		LRR 2	66..87		7/20 (35%)
		leucine-rich repeat	67..88	CDD:275378	7/20 (35%)
		LRR_4	87..129	CDD:289563	20/45 (44%)
		LRR 3	88..109		10/22 (45%)
		leucine-rich repeat	89..110	CDD:275378	11/22 (50%)
		LRR 4	110..131		9/22 (41%)
		leucine-rich repeat	111..132	CDD:275378	9/22 (41%)
		LRR 5	132..153		9/57 (16%)
		leucine-rich repeat	158..169	CDD:275378	4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910