DRSC/TRiP Functional Genomics Resources

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Protein Alignment rk and Lgr4

DIOPT Version :9

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:NP_775450.2 Gene:Lgr4 / 286994 RGDID:628615 Length:951 Species:Rattus norvegicus


Alignment Length:881 Identity:263/881 - (29%)
Similarity:407/881 - (46%) Gaps:107/881 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |.|.|.   .|:.|.|.|:.|||..|......||:..||:|:|..::|...|.||||.|:.|.:.
  Rat    33 CSCDGD---RRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKSFPFLEELQLAGNDLS 94

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLR 281
            .:.|.|..||.:||.|:|||..|:::|.::..||:.|.||:|:.|.:.|:..|....|.:||.|.
  Rat    95 FIHPKALSGLKELKVLTLQNNQLRTVPSEAIHGLSALQSLRLDANHITSVPEDSFEGLVQLRHLW 159

  Fly   282 LEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNL 346
            |:.|....:|...|:.|.||:||.|..|.::.|.|..|..:.:|:||.|..|:|..:|......|
  Rat   160 LDDNSLTEVPVRPLSNLPTLQALTLALNNISSIPDFAFTNLSSLVVLHLHNNKIKSLSQHCFDGL 224

  Fly   347 TALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWIND-----TELPRSMQMLDMRANPLST 406
            ..|:.|:|:.|.:...|:.:..|..|:||...||.:..|.|     ..|.|::.:.|   ||||.
  Rat   225 DNLETLDLNYNNLDEFPQAIKALPSLKELGFHSNSISVIPDGAFGGNPLLRTIHLYD---NPLSF 286

  Fly   407 ISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELK 471
            :...||..:|.|..|::.....::.||.|.....||.|.|....|..:|.:||:....|::|:|.
  Rat   287 VGNSAFHNLSDLHSLVIRGASLVQWFPNLTGTVHLESLTLTGTKISSIPDDLCQNQKMLRTLDLS 351

  Fly   472 TNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQ 536
            .|:::.:|:                        |||.:.|.::.|..|:|..:.::.|||:..|:
  Rat   352 YNNIRDLPS------------------------FNGCRALEEISLQRNQISLIKENTFQGLTSLR 392

  Fly   537 LLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFP 601
            :|||..|.|..||..||:....:.:|::..|.....|..||..|..||...|.||::......|.
  Rat   393 ILDLSRNLIREIHSGAFAKLGTITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKDALAARDFA 457

  Fly   602 RIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQ 666
            .:::|.:.|||.||||                    :..|:..::...:||     ||.|:::|:
  Rat   458 NLRSLSVPYAYQCCAF--------------------WGCDSYANLNTEDNS-----PQEHSVTKE 497

  Fly   667 LGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQ 731
            .||                    |.....||..|.  |||...                      
  Rat   498 KGA--------------------TDAANVTSTAEN--EEHSQI---------------------- 518

  Fly   732 PGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLA 796
              .:.|.|..|.|.||..|...|.:|..||.:||::||.|..|:..:..|.|.:...:..:..::
  Rat   519 --IIHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALLFNLLVILTVFASCSSLPASKLFIGLIS 581

  Fly   797 AADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYA 861
            .::..||||.|||..:||.:.|.|..|.|.|:....|:::|.|||.|||.:|:.|.:..:||:..
  Rat   582 VSNLLMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAGSLAVFSSESAVFLLTLAAVERSVF 646

  Fly   862 ITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKFAVCLPFETTTGPASLTYVISL 926
            ....:...|...|:|......:..:.|.:....||.....|....:||||.|...| ||.:.::|
  Rat   647 AKDLMKHGKSSHLRQFQVAALLALLGAAVAGCFPLFHGGQYSASPLCLPFPTGETP-SLGFTVTL 710

  Fly   927 MFINGCAFLTLMGCYLKMYWAIRGSQAWNTNDSRIAKRMALLVFTDFLCWSPIAFFSITAIFGLQ 991
            :.:|..|||.:...|.|:|..:........:.|.:.|.:|.|:||:.:.:.|:||||...:....
  Rat   711 VLLNSLAFLLMAIIYTKLYCNLEKEDLSENSQSSVIKHVAWLIFTNCIFFCPVAFFSFAPLITAI 775

  Fly   992 LISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKD 1027
            .||.|..|..|:...||.:|.||.||.....:||:|
  Rat   776 SISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKED 811

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380 8/20 (40%)
LRR_RI 180..>383 CDD:238064 72/202 (36%)
leucine-rich repeat 183..204 CDD:275380 7/20 (35%)
LRR_8 203..263 CDD:290566 26/59 (44%)
leucine-rich repeat 205..228 CDD:275380 10/22 (45%)
leucine-rich repeat 229..252 CDD:275380 10/22 (45%)
LRR_8 252..311 CDD:290566 22/58 (38%)
leucine-rich repeat 253..276 CDD:275380 8/22 (36%)
leucine-rich repeat 277..300 CDD:275380 8/22 (36%)
LRR_8 299..359 CDD:290566 21/59 (36%)
leucine-rich repeat 301..324 CDD:275380 8/22 (36%)
leucine-rich repeat 325..348 CDD:275380 8/22 (36%)
LRR_RI 327..567 CDD:238064 69/244 (28%)
leucine-rich repeat 349..371 CDD:275380 6/21 (29%)
LRR_8 370..425 CDD:290566 19/59 (32%)
leucine-rich repeat 372..393 CDD:275380 8/25 (32%)
leucine-rich repeat 394..415 CDD:275380 7/20 (35%)
leucine-rich repeat 418..486 CDD:275380 18/67 (27%)
leucine-rich repeat 441..464 CDD:275378 8/22 (36%)
LRR_8 487..545 CDD:290566 15/57 (26%)
leucine-rich repeat 487..510 CDD:275380 3/22 (14%)
leucine-rich repeat 511..534 CDD:275380 7/22 (32%)
LRR_8 533..589 CDD:290566 18/55 (33%)
leucine-rich repeat 535..558 CDD:275380 10/22 (45%)
leucine-rich repeat 559..580 CDD:275380 5/20 (25%)
7tm_4 764..>892 CDD:304433 38/127 (30%)
7tm_1 770..1017 CDD:278431 74/246 (30%)
Lgr4NP_775450.2 LRRNT 29..61 CDD:214470 11/30 (37%)
LRR 1 58..79 7/20 (35%)
leucine-rich repeat 59..82 CDD:275380 7/22 (32%)
LRR <62..301 CDD:227223 85/241 (35%)
LRR 2 82..103 8/20 (40%)
leucine-rich repeat 83..106 CDD:275380 10/22 (45%)
LRR 3 106..127 8/20 (40%)
leucine-rich repeat 107..130 CDD:275380 10/22 (45%)
LRR 4 130..151 7/20 (35%)
leucine-rich repeat 131..154 CDD:275380 8/22 (36%)
LRR 5 154..177 7/22 (32%)
leucine-rich repeat 155..178 CDD:275380 8/22 (36%)
LRR 6 178..199 9/20 (45%)
leucine-rich repeat 179..202 CDD:275380 8/22 (36%)
LRR 7 202..223 7/20 (35%)
leucine-rich repeat 203..226 CDD:275380 8/22 (36%)
LRR 8 226..247 5/20 (25%)
leucine-rich repeat 227..249 CDD:275380 6/21 (29%)
LRR 9 249..270 7/20 (35%)
leucine-rich repeat 250..273 CDD:275380 7/22 (32%)
LRR 10 273..294 9/23 (39%)
leucine-rich repeat 274..295 CDD:275380 8/23 (35%)
LRR 275..>465 CDD:227223 60/216 (28%)
LRR 11 320..341 8/20 (40%)
leucine-rich repeat 321..344 CDD:275378 8/22 (36%)
LRR 12 344..365 8/44 (18%)
LRR_8 345..401 CDD:404697 20/79 (25%)
leucine-rich repeat 345..366 CDD:275378 8/44 (18%)
LRR 13 366..387 5/20 (25%)
leucine-rich repeat 367..390 CDD:275378 7/22 (32%)
LRR 14 390..411 10/20 (50%)
leucine-rich repeat 391..414 CDD:275378 10/22 (45%)
LRR 15 414..435 5/20 (25%)
leucine-rich repeat 415..427 CDD:275378 2/11 (18%)
leucine-rich repeat 436..461 CDD:275380 7/24 (29%)
7tmA_LGR4 539..812 CDD:320483 87/274 (32%)
TM helix 1 541..565 CDD:320483 9/23 (39%)
TM helix 2 574..595 CDD:320483 6/20 (30%)
TM helix 3 619..641 CDD:320483 9/21 (43%)
TM helix 4 664..680 CDD:320483 1/15 (7%)
TM helix 5 704..727 CDD:320483 7/22 (32%)
TM helix 6 746..768 CDD:320483 9/21 (43%)
TM helix 7 780..805 CDD:320483 10/24 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2087
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 380 1.000 Inparanoid score I1993
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D171884at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm45552
orthoMCL 1 0.900 - - OOG6_106088
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X2481
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
109.730

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