DRSC/TRiP Functional Genomics Resources

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Protein Alignment rk and Lrrc4b

DIOPT Version :9

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:NP_937893.1 Gene:Lrrc4b / 272381 MGIID:3027390 Length:709 Species:Mus musculus


Alignment Length:521 Identity:121/521 - (23%)
Similarity:191/521 - (36%) Gaps:158/521 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   290 IPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLEL 354
            ||.|.       ..|||..|.:.:|..:.|..:.:|.:|.|.:|.:.||..||...|.:|..|||
Mouse    86 IPVNT-------RYLNLQENSIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLEL 143

  Fly   355 DDNLISSLP-EGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRGMSKL 418
            .||.::::| :....||:|:||        |              :|.||:.:|...||..:..|
Mouse   144 FDNRLTTVPTQAFEYLSKLREL--------W--------------LRNNPIESIPSYAFNRVPSL 186

  Fly   419 RKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSS 483
            |:|.|.:::.|....|.    |.|.|                  ..|:.|.|...:||.||||::
Mouse   187 RRLDLGELKRLEYISEA----AFEGL------------------VNLRYLNLGMCNLKDIPNLTA 229

  Fly   484 CRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYI 548
            ...|..|:||.|:::.|:...|.||..|..|.|.:.::..:.::||..:..|:.|:|..|.:..:
Mouse   230 LVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSL 294

  Fly   549 HKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSYAYH 613
            ..:.|:....||.::|.:|     |......:|.|..:    |:|..|.:|             .
Mouse   295 PHDLFTPLHRLERVHLNHN-----PWHCNCDVLWLSWW----LKETVPSNT-------------T 337

  Fly   614 CCA-----------------------FLPLV-----------AMSSQKK----TSQVQEAVLFPS 640
            |||                       :.|::           .|:::.|    ||......|.| 
Mouse   338 CCARCHAPAGLKGRYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRTGTSMTSVNWLTP- 401

  Fly   641 DAEFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEEQLQ---------TQTGGQIAT 696
                     |.::|.     |...:...:.:||   ..:||....:|         |.:.|....
Mouse   402 ---------NGTLMT-----HGSYRVRISVLHD---GTLNFTNVTVQDTGQYTCMVTNSAGNTTA 449

  Fly   697 SYMEEYFEEHDVS-----GPATGYGFGTGLFSG--------MSTEDFQPGSVQCLPM------PG 742
            |..........|:     |...|.|.|.|...|        :.|.:.|||.....|.      ||
Mouse   450 SATLNVSAVDPVAAGGPGGGGPGGGGGAGGAGGYTYFTTVTVETLETQPGEEAQQPRGTEKEPPG 514

  Fly   743 P 743
            |
Mouse   515 P 515

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380
LRR_RI 180..>383 CDD:238064 30/93 (32%)
leucine-rich repeat 183..204 CDD:275380
LRR_8 203..263 CDD:290566
leucine-rich repeat 205..228 CDD:275380
leucine-rich repeat 229..252 CDD:275380
LRR_8 252..311 CDD:290566 7/20 (35%)
leucine-rich repeat 253..276 CDD:275380
leucine-rich repeat 277..300 CDD:275380 3/9 (33%)
LRR_8 299..359 CDD:290566 21/59 (36%)
leucine-rich repeat 301..324 CDD:275380 6/22 (27%)
leucine-rich repeat 325..348 CDD:275380 9/22 (41%)
LRR_RI 327..567 CDD:238064 67/240 (28%)
leucine-rich repeat 349..371 CDD:275380 8/22 (36%)
LRR_8 370..425 CDD:290566 15/54 (28%)
leucine-rich repeat 372..393 CDD:275380 4/20 (20%)
leucine-rich repeat 394..415 CDD:275380 6/20 (30%)
leucine-rich repeat 418..486 CDD:275380 18/67 (27%)
leucine-rich repeat 441..464 CDD:275378 2/22 (9%)
LRR_8 487..545 CDD:290566 18/57 (32%)
leucine-rich repeat 487..510 CDD:275380 9/22 (41%)
leucine-rich repeat 511..534 CDD:275380 5/22 (23%)
LRR_8 533..589 CDD:290566 12/55 (22%)
leucine-rich repeat 535..558 CDD:275380 5/22 (23%)
leucine-rich repeat 559..580 CDD:275380 5/20 (25%)
7tm_4 764..>892 CDD:304433
7tm_1 770..1017 CDD:278431
Lrrc4bNP_937893.1 LRRNT 59..92 CDD:214470 3/12 (25%)
LRR <89..299 CDD:227223 71/260 (27%)
LRR 1 89..110 7/27 (26%)
leucine-rich repeat 90..113 CDD:275380 6/29 (21%)
LRR 2 113..134 8/20 (40%)
leucine-rich repeat 114..137 CDD:275380 9/22 (41%)
LRR 3 137..158 7/20 (35%)
leucine-rich repeat 138..161 CDD:275380 8/22 (36%)
LRR 4 161..182 10/42 (24%)
leucine-rich repeat 162..185 CDD:275380 10/44 (23%)
LRR 5 185..207 7/25 (28%)
leucine-rich repeat 186..210 CDD:275380 9/45 (20%)
LRR 6 210..231 9/20 (45%)
leucine-rich repeat 211..232 CDD:275380 9/20 (45%)
LRR 7 232..253 7/20 (35%)
leucine-rich repeat 233..256 CDD:275380 9/22 (41%)
LRR 8 256..277 5/20 (25%)
leucine-rich repeat 257..280 CDD:275380 5/22 (23%)
LRR 9 280..301 5/20 (25%)
leucine-rich repeat 281..302 CDD:275380 5/20 (25%)
LRRCT 313..363 CDD:214507 11/71 (15%)
I-set 366..455 CDD:400151 18/106 (17%)
Ig strand A 366..369 CDD:409353 1/2 (50%)
Ig strand A' 373..376 CDD:409353 0/2 (0%)
Ig strand B 382..389 CDD:409353 1/6 (17%)
Ig strand C 395..400 CDD:409353 0/4 (0%)
Ig strand C' 403..405 CDD:409353 0/1 (0%)
Ig strand D 414..418 CDD:409353 0/3 (0%)
Ig strand E 421..425 CDD:409353 0/3 (0%)
Ig strand F 435..442 CDD:409353 0/6 (0%)
Ig strand G 445..455 CDD:409353 2/9 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..552 7/20 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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