Protein Alignment rk and Lrig2

DIOPT Version :9

• Sequence 1: NP_476702.1
• Gene: rk / 34819
• FlyBaseID: FBgn0003255
• Length: 1360
• Species: Drosophila melanogaster
• Sequence 2: NP_001020238.1
• Gene: Lrig2 / 269473
• MGIID: 2443718
• Length: 1054
• Species: Mus musculus
• Alignment Length: 414
• Identity: 121/414 - (29%)
• Similarity: 186/414 - (44%)
• Gaps: 71/414 - (17%)

  Fly   231 RLSLQNCGLKSLPPQSFQGL-----AQLTSLQLNGNALV----SLDGDCLGHLQ----------- 275
            ||.|.:|..:.||..|::.|     :.::||.|:.|.|.    :|:...|..::
Mouse    49 RLPLLDCSRRKLPAPSWRALSGPLPSDISSLDLSHNRLSNWNNTLESQTLQEVKMNYNELTEIPY 113

  Fly   276 ------KLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQ 334
                  .:..|.|..||...|...|......||:|:|.||:::.|....|||| :|..|.|..|:
Mouse   114 FGEPTPNITLLSLVHNLIPEINAEAFELYSALESLDLSSNIISEIKTSSFPRM-SLKYLNLSNNR 177

  Fly   335 IMKISAGALKNLT-ALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELP--RSMQM 396
            |..:.||...||: :|.|::|:.|.||.:|..:.||..||.|.:..||::.:......  .|::.
Mouse   178 ISTLEAGCFDNLSDSLLVVKLNRNRISMIPPKVFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRS 242

  Fly   397 LDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPE--LEACHALEILKLDRAGIQEVPANLC 459
            |.|:.|.:|.:..|||.|::.:.:|.| :...|....:  |.....|:.|.:.:..|:::..:..
Mouse   243 LKMQRNGISKLKDGAFFGLNNMEELEL-EHNNLTGVNKGWLYGLRMLQQLYMSQNAIEKISPDAW 306

  Fly   460 RQTPRLKSLELKTNSLKRIP-------------NLSSCR-------------DLRLLDLSSNQIE 498
            ....||..|:|..|.|.|:.             ||...|             :|:.|||.:|.|.
Mouse   307 EFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNDIS 371

  Fly   499 ---KIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALE 560
               :...:.|:|||.|..|:|..||||::.|.||.|:..|:.|||..|.|..|.:.|||. |.|:
Mouse   372 WAIEDASEAFSGLKSLTKLILQGNRIKSVTQKAFIGLESLEYLDLNNNAIMSIQENAFSQ-THLK 435

  Fly   561 DLNLGNNIFPELPESGLRALLHLK 584
            .|.|..        |.|....|||
Mouse   436 GLVLNT--------SSLLCDCHLK 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	55/178 (31%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566	12/36 (33%)
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380	8/25 (32%)
		LRR_8	252..311	CDD:290566	19/79 (24%)
		leucine-rich repeat	253..276	CDD:275380	7/43 (16%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		LRR_8	299..359	CDD:290566	24/60 (40%)
		leucine-rich repeat	301..324	CDD:275380	11/22 (50%)
		leucine-rich repeat	325..348	CDD:275380	9/23 (39%)
		LRR_RI	327..567	CDD:238064	83/273 (30%)
		leucine-rich repeat	349..371	CDD:275380	9/21 (43%)
		LRR_8	370..425	CDD:290566	16/56 (29%)
		leucine-rich repeat	372..393	CDD:275380	5/22 (23%)
		leucine-rich repeat	394..415	CDD:275380	7/20 (35%)
		leucine-rich repeat	418..486	CDD:275380	17/95 (18%)
		leucine-rich repeat	441..464	CDD:275378	3/22 (14%)
		LRR_8	487..545	CDD:290566	26/60 (43%)
		leucine-rich repeat	487..510	CDD:275380	9/25 (36%)
		leucine-rich repeat	511..534	CDD:275380	11/22 (50%)
		LRR_8	533..589	CDD:290566	19/52 (37%)
		leucine-rich repeat	535..558	CDD:275380	10/22 (45%)
		leucine-rich repeat	559..580	CDD:275380	5/20 (25%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Lrig2	NP_001020238.1	LRR_RI	<16..204	CDD:238064	45/155 (29%)
		leucine-rich repeat	53..75	CDD:275378	5/21 (24%)
		LRR 1	75..96		6/20 (30%)
		LRR 2	97..118		1/20 (5%)
		leucine-rich repeat	98..120	CDD:275380	1/21 (5%)
		LRR_8	119..178	CDD:290566	21/59 (36%)
		LRR 3	120..141		6/20 (30%)
		leucine-rich repeat	121..144	CDD:275380	6/22 (27%)
		LRR_RI	<136..344	CDD:238064	60/209 (29%)
		LRR 4	144..165		8/20 (40%)
		leucine-rich repeat	145..167	CDD:275380	11/22 (50%)
		LRR_8	167..226	CDD:290566	22/58 (38%)
		LRR 5	167..188		7/20 (35%)
		leucine-rich repeat	168..192	CDD:275380	9/23 (39%)
		LRR 6	192..213		7/20 (35%)
		leucine-rich repeat	193..215	CDD:275380	9/21 (43%)
		LRR 7	215..236		5/20 (25%)
		leucine-rich repeat	216..239	CDD:275380	5/22 (23%)
		LRR_8	239..298	CDD:290566	15/59 (25%)
		LRR 8	239..260		8/20 (40%)
		leucine-rich repeat	240..263	CDD:275380	8/22 (36%)
		LRR 9	263..284		4/21 (19%)
		leucine-rich repeat	264..287	CDD:275380	4/23 (17%)
		LRR 10	287..308		3/20 (15%)
		leucine-rich repeat	288..311	CDD:275380	3/22 (14%)
		LRR_8	311..370	CDD:290566	15/58 (26%)
		LRR 11	311..332		7/20 (35%)
		leucine-rich repeat	312..335	CDD:275380	6/22 (27%)
		LRR 12	335..356		3/20 (15%)
		leucine-rich repeat	336..359	CDD:275380	3/22 (14%)
		LRR_8	358..421	CDD:290566	26/62 (42%)
		LRR_4	359..401	CDD:289563	17/41 (41%)
		LRR 13	359..381		6/21 (29%)
		leucine-rich repeat	360..384	CDD:275380	7/23 (30%)
		LRR_4	385..426	CDD:289563	19/40 (48%)
		LRR 14	386..407		10/20 (50%)
		leucine-rich repeat	387..410	CDD:275380	11/22 (50%)
		LRR 15	410..431		9/20 (45%)
		leucine-rich repeat	411..430	CDD:275380	8/18 (44%)
		LRRCT	444..492	CDD:214507	4/8 (50%)
		Ig	501..597	CDD:299845
		IG_like	503..597	CDD:214653
		I-set	601..691	CDD:254352
		Ig_1	618..692	CDD:143240
		I-set	695..782	CDD:254352
		Ig	713..782	CDD:299845

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910