DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and OPTC

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_055174.1	Gene:	OPTC / 26254	HGNCID:	8158	Length:	332	Species:	Homo sapiens

Alignment Length:	416	Identity:	109/416 - (26%)
Similarity:	153/416 - (36%)	Gaps:	130/416 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 LEVLRLSCRGIGILAVP--------VNLPNE---VVVLDLGNNNLTKLEANSFFMAPNLEELT-- 209
            |.:|.|..:..|..::|        ..:|.|   ..||.|.|:.|............|.||||
Human     7 LSLLALVLQETGTASLPRKERKRREEQMPREGDSFEVLPLRNDVLNPDNYGEVIDLSNYEELTDY 71

  Fly   210 ---LSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPP----QSFQGLAQLTSLQLNGNALVSLD 267
               |.:..:.::.|......||    |....|..|..|    .:..||  |.|.|.|
Human    72 GDQLPEVKVTSLAPATSISPAK----STTAPGTPSSNPTMTRPTTAGL--LLSSQPN-------- 122

  Fly   268 GDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNL-LTIINDEDFPRMPNLIVLLLK 331
                                :.:||       .|..:.|||:: ...|:.||.|.:|.....|..
Human   123 --------------------HGLPT-------CLVCVCLGSSVYCDDIDLEDIPPLPRRTAYLYA 160

  Fly   332 R-NQIMKISAGALKNLTALKVLELDDNLISSLP-EGLSKLSQLQELSITSNRLRWINDTELPRSM 394
            | |:|.:|.|...|.||.||.::|.:|||||:. :....|..||:|.:..|:|..:  ..||..:
Human   161 RFNRISRIRAEDFKGLTKLKRIDLSNNLISSIDNDAFRLLHALQDLILPENQLEAL--PVLPSGI 223

  Fly   395 QMLDMRANPL--STISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPAN 457
            :.||:|.|.|  |.|.|.|||.|.||:.|.|||
Human   224 EFLDVRLNRLQSSGIQPAAFRAMEKLQFLYLSD-------------------------------- 256

  Fly   458 LCRQTPRLKSLELKTNSLKRIPN---LSSCRDLRLLDLSSNQIEKIQGKPF-------NGLKQLN 512
                           |.|..||.   ||    ||.:.|.:|.||.:|...|       :..:||.
Human   257 ---------------NLLDSIPGPLPLS----LRSVHLQNNLIETMQRDVFCDPEEHKHTRRQLE 302

  Fly   513 DLLLSYNRIK-ALPQDAFQGIPKLQL 537
            |:.|..|.|. :|...|:..:|:|.:
Human   303 DIRLDGNPINLSLFPSAYFCLPRLPI 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	5/28 (18%)
		LRR_RI	180..>383	CDD:238064	58/217 (27%)
		leucine-rich repeat	183..204	CDD:275380	5/20 (25%)
		LRR_8	203..263	CDD:290566	19/68 (28%)
		leucine-rich repeat	205..228	CDD:275380	6/27 (22%)
		leucine-rich repeat	229..252	CDD:275380	6/26 (23%)
		LRR_8	252..311	CDD:290566	10/59 (17%)
		leucine-rich repeat	253..276	CDD:275380	4/22 (18%)
		leucine-rich repeat	277..300	CDD:275380	2/22 (9%)
		LRR_8	299..359	CDD:290566	22/61 (36%)
		leucine-rich repeat	301..324	CDD:275380	8/23 (35%)
		leucine-rich repeat	325..348	CDD:275380	8/23 (35%)
		LRR_RI	327..567	CDD:238064	67/226 (30%)
		leucine-rich repeat	349..371	CDD:275380	9/22 (41%)
		LRR_8	370..425	CDD:290566	23/56 (41%)
		leucine-rich repeat	372..393	CDD:275380	7/20 (35%)
		leucine-rich repeat	394..415	CDD:275380	11/22 (50%)
		leucine-rich repeat	418..486	CDD:275380	11/70 (16%)
		leucine-rich repeat	441..464	CDD:275378	0/22 (0%)
		LRR_8	487..545	CDD:290566	18/59 (31%)
		leucine-rich repeat	487..510	CDD:275380	8/29 (28%)
		leucine-rich repeat	511..534	CDD:275380	7/23 (30%)
		LRR_8	533..589	CDD:290566	2/5 (40%)
		leucine-rich repeat	535..558	CDD:275380	1/3 (33%)
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
OPTC	NP_055174.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	21..41		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	86..106		5/23 (22%)
		NEL	<115..>327	CDD:330839	82/301 (27%)
		LRR_8	153..213	CDD:316378	22/59 (37%)
		LRR 1	154..175		6/20 (30%)
		leucine-rich repeat	155..178	CDD:275380	8/22 (36%)
		LRR 2	178..199		8/20 (40%)
		leucine-rich repeat	179..202	CDD:275380	9/22 (41%)
		LRR 3	202..223		7/22 (32%)
		leucine-rich repeat	203..221	CDD:275380	6/19 (32%)
		leucine-rich repeat	223..248	CDD:275380	12/24 (50%)
		LRR 4	248..269		10/67 (15%)
		leucine-rich repeat	249..269	CDD:275380	9/66 (14%)
		leucine-rich repeat	270..300	CDD:275380	8/29 (28%)
		LRR 5	270..290		8/19 (42%)
		LRR 6	300..320		7/19 (37%)
		leucine-rich repeat	301..325	CDD:275380	7/23 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910