DRSC/TRiP Functional Genomics Resources

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Protein Alignment rk and LRRC32

DIOPT Version :9

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:NP_001122394.1 Gene:LRRC32 / 2615 HGNCID:4161 Length:662 Species:Homo sapiens


Alignment Length:479 Identity:149/479 - (31%)
Similarity:207/479 - (43%) Gaps:80/479 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   162 RLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAFYGL 226
            ::||:.:|:|.||..||.:...|||..|.|..:.|:.......|..|.||.|.|..:.|.||..|
Human    32 KVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQAL 96

  Fly   227 AKLKRLSLQNCGLKSLPPQSFQGLAQL---TSLQLNGNALVS-LDGDCLGHLQKLRTLRLEGNLF 287
            ..|:.|||.:..|......|..||..|   |||.|:||:|.| |....||....|.||.|..|..
Human    97 THLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSL 161

  Fly   288 YRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKV- 351
            .|:..:....:..||.|:|.||:|..|.|..|..:|.|..|.|.||.:..||..:|:.|..|.: 
Human   162 TRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLS 226

  Fly   352 ---------------------LELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQ 395
                                 |:|.:|.:...|: |:.|.:|..|::::|.:|.  .|..|:..:
Human   227 CNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPD-LAALPRLIYLNLSNNLIRL--PTGPPQDSK 288

  Fly   396 ML-----DMRANPLSTISPGAF-RGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEV 454
            .:     ...|.|||..|..|. |.:|:|..|.|       |:.|:|.                :
Human   289 GIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDL-------SYNEIEL----------------I 330

  Fly   455 PANLCRQTPRLKSLELKTNSLKRIP--NLSSCRDLRLLDLSSNQIEKIQ-GKPFNGLKQLNDLLL 516
            |.:.......|..|.|..|.|:...  .|.|...|.|||||.|.:|.:: |.  ..|..|..|||
Human   331 PDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA--RALGSLRTLLL 393

  Fly   517 SYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKE---------AFSGFTALEDLNLGNNIFPEL 572
            ..|.::.||...|..:..||.|:|:||.:|.....         ||||.|:|..|:|.:|.. ||
Human   394 QGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEI-EL 457

  Fly   573 PESGLRALLH-----LKTFNNPKL 591
            ..:|  |.||     |...:||.|
Human   458 LRAG--AFLHTPLTELDLSSNPGL 479

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380 7/16 (44%)
LRR_RI 180..>383 CDD:238064 72/228 (32%)
leucine-rich repeat 183..204 CDD:275380 6/20 (30%)
LRR_8 203..263 CDD:290566 25/62 (40%)
leucine-rich repeat 205..228 CDD:275380 10/22 (45%)
leucine-rich repeat 229..252 CDD:275380 8/22 (36%)
LRR_8 252..311 CDD:290566 24/62 (39%)
leucine-rich repeat 253..276 CDD:275380 12/26 (46%)
leucine-rich repeat 277..300 CDD:275380 6/22 (27%)
LRR_8 299..359 CDD:290566 24/81 (30%)
leucine-rich repeat 301..324 CDD:275380 10/22 (45%)
leucine-rich repeat 325..348 CDD:275380 9/22 (41%)
LRR_RI 327..567 CDD:238064 76/279 (27%)
leucine-rich repeat 349..371 CDD:275380 7/43 (16%)
LRR_8 370..425 CDD:290566 17/60 (28%)
leucine-rich repeat 372..393 CDD:275380 6/20 (30%)
leucine-rich repeat 394..415 CDD:275380 7/26 (27%)
leucine-rich repeat 418..486 CDD:275380 14/69 (20%)
leucine-rich repeat 441..464 CDD:275378 1/22 (5%)
LRR_8 487..545 CDD:290566 24/58 (41%)
leucine-rich repeat 487..510 CDD:275380 10/23 (43%)
leucine-rich repeat 511..534 CDD:275380 8/22 (36%)
LRR_8 533..589 CDD:290566 23/69 (33%)
leucine-rich repeat 535..558 CDD:275380 11/31 (35%)
leucine-rich repeat 559..580 CDD:275380 7/20 (35%)
7tm_4 764..>892 CDD:304433
7tm_1 770..1017 CDD:278431
LRRC32NP_001122394.1 LRR_RI 19..277 CDD:238064 80/245 (33%)
leucine-rich repeat 31..50 CDD:275380 8/17 (47%)
PLN00113 49..>574 CDD:215061 141/462 (31%)
LRR 1. /evidence=ECO:0000255 50..73 6/22 (27%)
leucine-rich repeat 51..74 CDD:275380 6/22 (27%)
LRR 2. /evidence=ECO:0000255 74..95 9/20 (45%)
leucine-rich repeat 75..98 CDD:275380 10/22 (45%)
LRR 3. /evidence=ECO:0000255 98..119 6/20 (30%)
leucine-rich repeat 99..125 CDD:275380 9/25 (36%)
LRR 4. /evidence=ECO:0000255 125..145 9/19 (47%)
leucine-rich repeat 126..150 CDD:275380 11/23 (48%)
LRR 5. /evidence=ECO:0000255 150..171 6/20 (30%)
leucine-rich repeat 151..174 CDD:275380 6/22 (27%)
LRR 6. /evidence=ECO:0000255 174..195 10/20 (50%)
leucine-rich repeat 175..198 CDD:275380 10/22 (45%)
LRR 7. /evidence=ECO:0000255 198..219 8/20 (40%)
leucine-rich repeat 199..219 CDD:275380 8/19 (42%)
leucine-rich repeat 220..244 CDD:275380 2/23 (9%)
LRR 8. /evidence=ECO:0000255 220..240 2/19 (11%)
LRR 9. /evidence=ECO:0000255 244..265 5/21 (24%)
leucine-rich repeat 245..266 CDD:275380 6/21 (29%)
LRR 10. /evidence=ECO:0000255 266..286 6/21 (29%)
LRR 11. /evidence=ECO:0000255 316..339 7/45 (16%)
leucine-rich repeat 317..340 CDD:275380 7/45 (16%)
LRR 12. /evidence=ECO:0000255 340..363 7/22 (32%)
leucine-rich repeat 341..364 CDD:275380 7/22 (32%)
LRR 13. /evidence=ECO:0000255 364..385 9/22 (41%)
leucine-rich repeat 365..387 CDD:275380 10/23 (43%)
LRR 14. /evidence=ECO:0000255 387..408 8/20 (40%)
leucine-rich repeat 388..411 CDD:275380 8/22 (36%)
LRR 15. /evidence=ECO:0000255 411..432 7/20 (35%)
leucine-rich repeat 412..444 CDD:275380 11/31 (35%)
LRR 16. /evidence=ECO:0000255 444..465 8/23 (35%)
leucine-rich repeat 445..463 CDD:275380 7/20 (35%)
LRR 17. /evidence=ECO:0000255 467..488 4/13 (31%)
leucine-rich repeat 468..492 CDD:275380 4/12 (33%)
LRR 18. /evidence=ECO:0000255 492..513
leucine-rich repeat 493..515 CDD:275380
PLN03150 <496..654 CDD:178695
LRR 19. /evidence=ECO:0000255 515..536
leucine-rich repeat 516..537 CDD:275380
LRR 20. /evidence=ECO:0000255 537..558
leucine-rich repeat 538..559 CDD:275380
leucine-rich repeat 563..575 CDD:275378
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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