DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and TSKU

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001305406.1	Gene:	TSKU / 25987	HGNCID:	28850	Length:	367	Species:	Homo sapiens

Alignment Length:	486	Identity:	110/486 - (22%)
Similarity:	165/486 - (33%)	Gaps:	193/486 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CHCT-------GSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAP---NLE 206
            |.|.       .|..:.|:.|.|:|...:||.:|.:...|||.:|.| ::...|....|   .|.
Human    38 CQCEVETFGLFDSFSLTRVDCSGLGPHIMPVPIPLDTAHLDLSSNRL-EMVNESVLAGPGYTTLA 101

  Fly   207 ELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCL 271
            .|.||.|.:.::.|.||..|..|:.|.|.:.||.:||.:||.. :.|:.:.|:.|.|..:.....
Human   102 GLDLSHNLLTSISPTAFSRLRYLESLDLSHNGLTALPAESFTS-SPLSDVNLSHNQLREVSVSAF 165

  Fly   272 GHLQKLRTLR--LEGNLFYRI---PTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLK 331
            ....:.|.|.  |..||.:|:   ||.|.....|:::|||..|.|..:        |||
Human   166 TTHSQGRALHVDLSHNLIHRLVPHPTRAGLPAPTIQSLNLAWNRLHAV--------PNL------ 216

  Fly   332 RNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQM 396
                                                                    .:||  ::.
Human   217 --------------------------------------------------------RDLP--LRY 223

  Fly   397 LDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQ 461
            |.:..|||:.|.||||.|:..|..|.|:
Human   224 LSLDGNPLAVIGPGAFAGLGGLTHLSLA------------------------------------- 251

  Fly   462 TPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQ 526
                        ||:|:|.|:                                           .
Human   252 ------------SLQRLPELA-------------------------------------------P 261

  Fly   527 DAFQGIPKLQLLDLEGN-EISYIHKEAFSGFTALEDLNL-GNNIFPELPESGLRALLHLKTF--- 586
            ..|:.:|.||:|||.|| ::::...|.|||.::|::|:| |.|:.| |||:   .||||...
Human   262 SGFRELPGLQVLDLSGNPKLNWAGAEVFSGLSSLQELDLSGTNLVP-LPEA---LLLHLPALQSV 322

  Fly   587 ---NNPKLREFPPPDTFPRIQTLILSYAYHC 614
               .:.:.|......|:||........|.||
Human   323 SVGQDVRCRRLVREGTYPRRPGSSPKVALHC 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	6/20 (30%)
		LRR_RI	180..>383	CDD:238064	47/210 (22%)
		leucine-rich repeat	183..204	CDD:275380	7/23 (30%)
		LRR_8	203..263	CDD:290566	22/62 (35%)
		leucine-rich repeat	205..228	CDD:275380	9/22 (41%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		LRR_8	252..311	CDD:290566	18/63 (29%)
		leucine-rich repeat	253..276	CDD:275380	4/22 (18%)
		leucine-rich repeat	277..300	CDD:275380	9/27 (33%)
		LRR_8	299..359	CDD:290566	9/59 (15%)
		leucine-rich repeat	301..324	CDD:275380	5/22 (23%)
		leucine-rich repeat	325..348	CDD:275380	1/22 (5%)
		LRR_RI	327..567	CDD:238064	37/241 (15%)
		leucine-rich repeat	349..371	CDD:275380	0/21 (0%)
		LRR_8	370..425	CDD:290566	15/54 (28%)
		leucine-rich repeat	372..393	CDD:275380	2/20 (10%)
		leucine-rich repeat	394..415	CDD:275380	9/20 (45%)
		leucine-rich repeat	418..486	CDD:275380	8/67 (12%)
		leucine-rich repeat	441..464	CDD:275378	0/22 (0%)
		LRR_8	487..545	CDD:290566	9/58 (16%)
		leucine-rich repeat	487..510	CDD:275380	0/22 (0%)
		leucine-rich repeat	511..534	CDD:275380	1/22 (5%)
		LRR_8	533..589	CDD:290566	25/63 (40%)
		leucine-rich repeat	535..558	CDD:275380	11/23 (48%)
		leucine-rich repeat	559..580	CDD:275380	9/21 (43%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
TSKU	NP_001305406.1	LRR_RI	52..305	CDD:238064	91/418 (22%)
		leucine-rich repeat	76..99	CDD:275380	7/23 (30%)
		leucine-rich repeat	100..123	CDD:275380	9/22 (41%)
		LRR_8	103..157	CDD:290566	20/54 (37%)
		leucine-rich repeat	124..145	CDD:275380	9/21 (43%)
		leucine-rich repeat	147..170	CDD:275380	4/22 (18%)
		leucine-rich repeat	171..197	CDD:275380	9/25 (36%)
		leucine-rich repeat	200..219	CDD:275380	8/88 (9%)
		LRR_8	221..279	CDD:290566	26/149 (17%)
		leucine-rich repeat	221..244	CDD:275380	10/22 (45%)
		leucine-rich repeat	245..269	CDD:275380	9/115 (8%)
		LRR_8	268..321	CDD:290566	25/56 (45%)
		leucine-rich repeat	270..294	CDD:275380	11/23 (48%)
		leucine-rich repeat	295..316	CDD:275380	11/24 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910