DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Hcrtr2

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_037206.1	Gene:	Hcrtr2 / 25605	RGDID:	2788	Length:	460	Species:	Rattus norvegicus

Alignment Length:	451	Identity:	97/451 - (21%)
Similarity:	163/451 - (36%)	Gaps:	122/451 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   743 PFLPCADLFD-------W----------WTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRF 790
            |||...|..|       |          |.|..|..:||:::|:||..|...:..:.....|..:
  Rat    27 PFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNY 91

  Fly   791 LVCNLAAADFFMGI-YLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVI 854
            .:.||:.||..:.| .|....:||   :.|...|.     ..||::..:|..:|..:||.||:.|
  Rat    92 FIVNLSLADVLVTITCLPATLVVD---ITETWFFG-----QSLCKVIPYLQTVSVSVSVLTLSCI 148

  Fly   855 TLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIM-----------ALMP-------LVGVSD 901
            .|:|.|||.|.:..  :.:.|:|...:.|.|:.:.|:           :::|       |..|.|
  Rat   149 ALDRWYAICHPLMF--KSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCD 211

  Fly   902 YR--------KFAVCLPFETTTGPASLTYVISLMFIN--GCAFLTLMGCYLKMYW-------AIR 949
            .|        .:.:|....|...|..|..:..|....  .|..:......::..|       ..|
  Rat   212 ERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPR 276

  Fly   950 GS-QAWNTNDSRIA------------KRMALLVFTDF-LCWSPIAFFSI-TAIFGLQLISLEQAK 999
            || |......|.:|            .||.::|...| :|:.||:..:: ..:||:...:.::..
  Rat   277 GSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRET 341

  Fly  1000 IFTVF-----VLPLNSCCNPFLYAIMTKQFK---KDCVTLCKHFEESRVVGGGGPGGRGAVARTK 1056
            ::..|     ::..||..||.:|..::.:|:   |...:.|......:    |....||..:...
  Rat   342 VYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQ----GDRLARGRTSTES 402

  Fly  1057 RGDLPPPL--------------------LPAAAVAHPPGCRCLRMLPSEMPNWHKMEQTPS 1097
            |..|...:                    ||||..|.|            :.||:..:..||
  Rat   403 RKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGP------------LQNWYLQQGVPS 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	36/139 (26%)
		7tm_1	770..1017	CDD:278431	66/302 (22%)
Hcrtr2	NP_037206.1	Required for response to orexin-A. /evidence=ECO:0000250\|UniProtKB:O43614	33..49		3/15 (20%)
		7tm_4	65..>185	CDD:304433	36/129 (28%)
		7tm_1	71..364	CDD:278431	66/302 (22%)
		Orexin_rec2	386..443	CDD:281778	11/72 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910