DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Cnr1

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_036916.1	Gene:	Cnr1 / 25248	RGDID:	2369	Length:	473	Species:	Rattus norvegicus

Alignment Length:	380	Identity:	87/380 - (22%)
Similarity:	155/380 - (40%)	Gaps:	74/380 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   696 TSYMEEYFEEHDVSG---PATGYGFGTGL--FSGMSTEDFQPG--SVQC-----------LPMPG 742
            ||:....|:|...:|   |....|..|.:  |...|...|:..  ::||           :..|.
  Rat    51 TSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPS 115

  Fly   743 PFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRF-LVCNLAAADFFMGIYL 806
            ..|..|.|    :|..|.:.|     |.|..|:.|:|.|||....|.: .:.:||.|| .:|..:
  Rat   116 QQLAIAVL----SLTLGTFTV-----LENLLVLCVILHSRSLRCRPSYHFIGSLAVAD-LLGSVI 170

  Fly   807 GILAIVDAATLGEFRMFAIPWQMSV-LCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNK 870
            .:.:.||      |.:|......:| |.:|.|..|  |...||.:|.:..::|..:|...:...:
  Rat   171 FVYSFVD------FHVFHRKDSPNVFLFKLGGVTA--SFTASVGSLFLTAIDRYISIHRPLAYKR 227

  Fly   871 RLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKFAVC---LPFETTTGPASLTYVISLMFINGC 932
            .::..:|.....:.|..|:::|::||:|.:..:..:||   .|.      ...||::..:.:...
  Rat   228 IVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPL------IDETYLMFWIGVTSV 286

  Fly   933 AFLTLMGCYLKMYWAI---------RGSQ---AWNTN---------------DSRIAKRMALLVF 970
            ..|.::..|:.:.|..         ||:|   ..:|:               |.|:||.:.|::.
  Rat   287 LLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILV 351

  Fly   971 TDFLCWSPIAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFK 1025
            ...:||.|:....:..:||.....::....|...:..|||..||.:||:.:|..:
  Rat   352 VLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLR 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	32/129 (25%)
		7tm_1	770..1017	CDD:278431	63/278 (23%)
Cnr1	NP_036916.1	Required for mitochondrial localization. /evidence=ECO:0000250\|UniProtKB:P47746	2..23
		7tmA_CB1	118..409	CDD:320462	73/313 (23%)
		TM helix 1	120..144	CDD:320462	9/32 (28%)
		TM helix 2	154..175	CDD:320462	5/21 (24%)
		TM helix 3	191..213	CDD:320462	8/23 (35%)
		TM helix 4	236..252	CDD:320462	3/15 (20%)
		TM helix 5	273..296	CDD:320462	3/22 (14%)
		TM helix 6	343..365	CDD:320462	6/21 (29%)
		TM helix 7	377..402	CDD:320462	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910