DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rk and Phlpp2

DIOPT Version :9

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:NP_001116066.2 Gene:Phlpp2 / 244650 MGIID:2444928 Length:1355 Species:Mus musculus


Alignment Length:1546 Identity:315/1546 - (20%)
Similarity:501/1546 - (32%) Gaps:563/1546 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 TKENPAPDMQNSQEQEPYVHLQ-HLQQQQQQNPQTVQQLSQITVNRTSKSASVTPTGIRENVMLP 100
            |.|.||.::...:.:|. ::|| |....::..|.  ::..||..:..|:.....|..|:|.    
Mouse   100 TVETPASEICAGEGRES-LYLQLHGDLVRRLEPS--ERPLQIVYDYLSRLGFEDPVRIQEE---- 157

  Fly   101 SADPEKEAQILY--EKSLQEYHGSQLSTASTATDVIAGKRTLHSICERWL-----------QKHC 152
            :.:|:....|.:  ||..|..|..:: ..|...:|..||..||...||.:           .|.|
Mouse   158 ATNPDLSCMIRFYGEKPCQMDHLDRI-LLSGIYNVRKGKTQLHKWAERLVVLCGTCLIVSSVKDC 221

  Fly   153 HCTGSLEVL-------------------------------------------------------- 161
            . ||.:.:|                                                        
Mouse   222 Q-TGKMHILPLVGGKIEEVKRRQHSLAFSSAGAQAQTYHVSFETLAEYQRWQRQASKVVSQRMST 285

  Fly   162 -RLSCRGIGILAVPVNL--PNEVVVLDLGNNNLTKLE----ANSFFMAPNLEELTLSDNSIINMD 219
             .|||  ..:..||.:|  ..::..|:| .:|..:||    .::......|:.|.||.|. :.:.
Mouse   286 VDLSC--YSLEEVPEHLFYSQDITYLNL-RHNFMQLERPGGLDTLHKFSQLKGLNLSHNK-LGLF 346

  Fly   220 PNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEG 284
            |.....::.|..|||...|...||.| ...|..|.:|.|:||.|.:|. |.||:|::|.:|.:..
Mouse   347 PVLLCEISTLTELSLSCNGFHDLPSQ-IGKLLNLQTLSLDGNGLTALP-DELGNLRQLTSLGISF 409

  Fly   285 NLFYRIP----------TNALAGLRTLEALNLG---------------SNLLTII---------- 314
            |.|..||          ..|:||.| ||.||||               ::|.|:|          
Mouse   410 NDFRHIPEVLEKLTMLDKVAMAGNR-LEVLNLGALTRMSQVKHVDLRMNHLKTVITENMEGNKHI 473

  Fly   315 ----------NDEDFPRMPNLIVLLLKRNQIMKISAGAL---------KNLTALKV--------- 351
                      .|.|...:.:|..|..:|||:.:::....         ..|||:.|         
Mouse   474 THMDLRDNQLTDLDLSSLCSLEQLHCERNQLRELTLSGFSLRTLYASWNRLTAVNVYPVPSLLTS 538

  Fly   352 LELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRGMS 416
            |||..||:..:|:...:..:|:.|.|:.|.|     ||:|       ||.  ||::|        
Mouse   539 LELSQNLLECVPDWACEAKKLEILDISHNLL-----TEVP-------MRI--LSSLS-------- 581

  Fly   417 KLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNL 481
             ||||::.. ..:...|.|.....||:|.:....:..:|..|..:...|:.|....|||:.:|  
Mouse   582 -LRKLMVGH-NHIHVLPALVEHIPLEVLDIQHNTLSRLPDTLFSKALNLRYLNASANSLESLP-- 642

  Fly   482 SSCR------------------------------DLRLLDLSSNQIEKIQGKPFNGLKQLNDLLL 516
            |:|.                              .||:|.|::||::.......|.|:||.:|.|
Mouse   643 SACAGEESLSVLQLLYLTSNLLTDQCIPVLVGHPHLRVLHLANNQLQTFPASKLNKLEQLEELNL 707

  Fly   517 SYNRIKALP----------------------QDAFQGIPKLQLLDLEGNEISYI-HKEAFSGFTA 558
            |.|::.|:|                      .:..| :|::|.:||..|:::.| ..||..  ..
Mouse   708 SGNKLTAIPTTIANCKRLHTLVAHANNISIFPEILQ-LPQIQFVDLSCNDLTEILIPEALP--AT 769

  Fly   559 LEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSYAYHCCAFLPLVAM 623
            |:||:|..|         ...:|..||.           |.|..|..|                 
Mouse   770 LQDLDLTGN---------TNLVLEHKTL-----------DMFSHITAL----------------- 797

  Fly   624 SSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEEQLQT 688
                   ::.:..|..:|:....|.|::.:..:..|.:.|.                        
Mouse   798 -------KIDQKPLPATDSAVTSTFWSHGLAEMAGQRNKLC------------------------ 831

  Fly   689 QTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQPGSVQCLPMPGPFLPCADLFDW 753
                 ::...|:.:         |.|.|...|:|.|...|:. |..:||        ..||:   
Mouse   832 -----VSALAMDNF---------AEGVGAVYGMFDGDRNEEL-PRLLQC--------TMADV--- 870

  Fly   754 WTLRCGVWVVFLLSLLGNGT--VVFV---LLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVD 813
                       ||..:.:.|  .||:   .|.|..|:.:              .|..||..|:  
Mouse   871 -----------LLEEVQHSTNDTVFMTNTFLVSHRKLGM--------------AGQKLGSSAL-- 908

  Fly   814 AATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAG 878
                              ||.:....|..:|..|: |:|      |..:..|:       |.:.|
Mouse   909 ------------------LCYIRPDTADPTSSFSL-TVA------NVGMCQAV-------LCRGG 941

  Fly   879 YIMSVGWVFALIMALMPLVGVSDYRKFAVCLPFETTTGPASLTYVISLMFINGCAFLT-LMGCYL 942
            ..:.:..||:|.........|.|.:                 ..:.....:||....| |:||..
Mouse   942 KPVPLSKVFSLEHDPEEAQRVKDQK-----------------AIITEDNKVNGVTCCTRLLGCTY 989

  Fly   943 KMYWAIRGSQAWNTNDSRIAKRMALLVFTDFLCWSPIAFF-SITAIFGLQLISLEQAKIFTVFVL 1006
            ...|.:......:|   .:..:..||:..:...|..:::. ::.|:..:|               
Mouse   990 LYPWILPKPHIAST---PLTIQDELLILGNKALWEHLSYLEAVNAVRHVQ--------------- 1036

  Fly  1007 PLNSCCNPFLYAIMTKQFKKDCVTLCKHFEESRVVGG---------------------GGPGGRG 1050
                  :|...|      ||.| ||.:.:.....||.                     .||.|..
Mouse  1037 ------DPLAAA------KKLC-TLAQSYGCQDNVGAMVVYLNIGEEGCTCEMNGLTLPGPVGFA 1088

  Fly  1051 AVARTKRGDLPPPLLPAAA--VAHPPGCRCLRMLPSEMPNWHKMEQTPSMWQRLRTFCCGENRRR 1113
            :.|..|  |.|.|..|:::  :|..        ..|||.......:..|      |.....|...
Mouse  1089 STAALK--DTPKPTTPSSSSGIASE--------FSSEMSTSEVSSEVGS------TASDEHNTVG 1137

  Fly  1114 RKQRRQPQ-QRRQRAYTAAAANPYQYQFAELRQQRQNRASSISSENFCSSRSSSWRHG------- 1170
            .:....|: :||...:.|::|..:|      ||......||..|:|...|.......|       
Mouse  1138 LEASLLPRPERRCSLHPASSAGVFQ------RQPSCATFSSNQSDNGLDSDDDQPVEGVITNGSR 1196

  Fly  1171 --------------PPSSAPVPPGN---CSMPLKMLEPHAHPHGHGRRRHSAWLITRKTSQDSN- 1217
                          |.||.|:|..:   ||      |..|...|.|        |.|:.|.:|. 
Mouse  1197 VEVEVDIHCCRGREPESSPPLPKNSSNACS------EERARGAGFG--------IRRQNSVNSGI 1247

  Fly  1218 LSSSRNDSSASATTASTSTFRLSRSSAGSSTPLPSII--------AHNGK-------AQLDA--- 1264
            |..:..|......:.|||.....:.|.||..||...:        |...|       .||:.   
Mouse  1248 LLPANRDKMELQKSPSTSCLYGKKLSNGSIVPLEDSLNLIEVATEAPKRKTGYFAAPTQLEPEDQ 1312

  Fly  1265 -VKPR----LVRQEAVQEEEDSSPPRLGVRFLPTIPSAADSSVVMEDGDSA 1310
             |.||    .|:::..|.:|....|.         |...:.:..:|:.|:|
Mouse  1313 FVVPRDLEEEVKEQMKQHQEGRPEPE---------PRGEERTEPLEEFDTA 1354

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380 7/79 (9%)
LRR_RI 180..>383 CDD:238064 71/269 (26%)
leucine-rich repeat 183..204 CDD:275380 5/24 (21%)
LRR_8 203..263 CDD:290566 20/59 (34%)
leucine-rich repeat 205..228 CDD:275380 6/22 (27%)
leucine-rich repeat 229..252 CDD:275380 9/22 (41%)
LRR_8 252..311 CDD:290566 27/83 (33%)
leucine-rich repeat 253..276 CDD:275380 11/22 (50%)
leucine-rich repeat 277..300 CDD:275380 9/32 (28%)
LRR_8 299..359 CDD:290566 25/112 (22%)
leucine-rich repeat 301..324 CDD:275380 11/57 (19%)
leucine-rich repeat 325..348 CDD:275380 6/31 (19%)
LRR_RI 327..567 CDD:238064 75/310 (24%)
leucine-rich repeat 349..371 CDD:275380 7/30 (23%)
LRR_8 370..425 CDD:290566 17/54 (31%)
leucine-rich repeat 372..393 CDD:275380 8/20 (40%)
leucine-rich repeat 394..415 CDD:275380 5/20 (25%)
leucine-rich repeat 418..486 CDD:275380 19/97 (20%)
leucine-rich repeat 441..464 CDD:275378 5/22 (23%)
LRR_8 487..545 CDD:290566 22/79 (28%)
leucine-rich repeat 487..510 CDD:275380 8/22 (36%)
leucine-rich repeat 511..534 CDD:275380 8/44 (18%)
LRR_8 533..589 CDD:290566 16/56 (29%)
leucine-rich repeat 535..558 CDD:275380 7/23 (30%)
leucine-rich repeat 559..580 CDD:275380 5/20 (25%)
7tm_4 764..>892 CDD:304433 26/132 (20%)
7tm_1 770..1017 CDD:278431 40/253 (16%)
Phlpp2NP_001116066.2 PH_PHLPP-like 181..275 CDD:270131 13/95 (14%)
leucine-rich repeat 285..305 CDD:275380 6/21 (29%)
leucine-rich repeat 306..332 CDD:275380 5/26 (19%)
LRR_RI 309..548 CDD:238064 66/243 (27%)
LRR_8 354..412 CDD:290566 23/59 (39%)
leucine-rich repeat 356..378 CDD:275380 9/22 (41%)
leucine-rich repeat 379..401 CDD:275380 11/22 (50%)
leucine-rich repeat 402..424 CDD:275380 6/21 (29%)
LRR_8 425..483 CDD:290566 13/58 (22%)
leucine-rich repeat 425..448 CDD:275380 10/23 (43%)
LRR_RI 447..714 CDD:238064 66/292 (23%)
leucine-rich repeat 449..472 CDD:275380 3/22 (14%)
leucine-rich repeat 474..493 CDD:275380 2/18 (11%)
leucine-rich repeat 494..513 CDD:275380 5/18 (28%)
leucine-rich repeat 514..535 CDD:275380 4/20 (20%)
LRR_8 536..592 CDD:290566 23/79 (29%)
leucine-rich repeat 536..558 CDD:275380 6/21 (29%)
leucine-rich repeat 559..581 CDD:275380 12/35 (34%)
leucine-rich repeat 582..597 CDD:275380 4/15 (27%)
LRR_8 604..664 CDD:290566 13/61 (21%)
leucine-rich repeat 604..627 CDD:275380 5/22 (23%)
leucine-rich repeat 628..653 CDD:275380 8/26 (31%)
leucine-rich repeat 654..677 CDD:275380 0/22 (0%)
LRR_8 676..735 CDD:290566 16/58 (28%)
leucine-rich repeat 678..701 CDD:275380 8/22 (36%)
leucine-rich repeat 702..724 CDD:275380 7/21 (33%)
leucine-rich repeat 747..768 CDD:275380 7/22 (32%)
PP2Cc 816..1065 CDD:238083 66/405 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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