DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Tsku

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001019790.1	Gene:	Tsku / 244152	MGIID:	2443855	Length:	354	Species:	Mus musculus

Alignment Length:	463	Identity:	99/463 - (21%)
Similarity:	162/463 - (34%)	Gaps:	180/463 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CHCT-------GSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAP---NLE 206
            |.|.       .|..::|:.|..:|...|||.:|.:...|||.:|.|..:. .|....|   .|.
Mouse    25 CQCEEETFGLFDSFSLIRVDCSSLGPHIVPVPIPLDTAHLDLSSNRLETVN-ESVLAGPGYTTLA 88

  Fly   207 ELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCL 271
            .|.||.|.:.::.|:||..|..|:.|.|.:.||.:||.:.|.
Mouse    89 GLDLSYNLLTSIMPSAFSRLRYLESLDLSHNGLAALPAEIFT----------------------- 130

  Fly   272 GHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIM 336
                                                |:.|:.||              |..|::.
Mouse   131 ------------------------------------SSPLSDIN--------------LSHNRLR 145

  Fly   337 KISAGALKNLTALKVLELD--DNLI---------SSLPEGLSKLSQLQELSITSNRLRWIND-TE 389
            ::|..|....:..:.|.:|  .|||         :|||     ...:|.|:::.||.|.:.| .:
Mouse   146 EVSISAFTTHSQGRALHVDLSHNLIHRLLPHPARASLP-----APTIQSLNLSWNRFRAVPDLRD 205

  Fly   390 LPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEV 454
            ||  ::.|.:..|||:||:|.||.|::.|..|.|:.::              .||.|...|.:|:
Mouse   206 LP--LRYLSLDGNPLATINPDAFMGLAGLTHLSLASLQ--------------GILHLPPHGFREL 254

  Fly   455 PANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYN 519
            |.                              |::||||.|.
Mouse   255 PG------------------------------LQVLDLSGNP----------------------- 266

  Fly   520 RIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNI----------FPELPE 574
            ::|....:.|.|:..||.|||.|:.:..:.:.......||:.:::|.::          :...|.
Mouse   267 KLKWAGAEVFSGLGLLQELDLSGSSLVPLPEMLLHHLPALQSVSVGQDVQCRRLVREGAYHRQPG 331

  Fly   575 SGLRALLH 582
            |..:.:||
Mouse   332 SSPKVVLH 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	6/20 (30%)
		LRR_RI	180..>383	CDD:238064	44/216 (20%)
		leucine-rich repeat	183..204	CDD:275380	7/23 (30%)
		LRR_8	203..263	CDD:290566	18/62 (29%)
		leucine-rich repeat	205..228	CDD:275380	9/22 (41%)
		leucine-rich repeat	229..252	CDD:275380	8/22 (36%)
		LRR_8	252..311	CDD:290566	1/58 (2%)
		leucine-rich repeat	253..276	CDD:275380	0/22 (0%)
		leucine-rich repeat	277..300	CDD:275380	0/22 (0%)
		LRR_8	299..359	CDD:290566	11/61 (18%)
		leucine-rich repeat	301..324	CDD:275380	4/22 (18%)
		leucine-rich repeat	325..348	CDD:275380	4/22 (18%)
		LRR_RI	327..567	CDD:238064	57/251 (23%)
		leucine-rich repeat	349..371	CDD:275380	8/32 (25%)
		LRR_8	370..425	CDD:290566	21/55 (38%)
		leucine-rich repeat	372..393	CDD:275380	8/21 (38%)
		leucine-rich repeat	394..415	CDD:275380	9/20 (45%)
		leucine-rich repeat	418..486	CDD:275380	9/67 (13%)
		leucine-rich repeat	441..464	CDD:275378	6/22 (27%)
		LRR_8	487..545	CDD:290566	15/57 (26%)
		leucine-rich repeat	487..510	CDD:275380	6/22 (27%)
		leucine-rich repeat	511..534	CDD:275380	3/22 (14%)
		LRR_8	533..589	CDD:290566	13/60 (22%)
		leucine-rich repeat	535..558	CDD:275380	6/22 (27%)
		leucine-rich repeat	559..580	CDD:275380	4/30 (13%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Tsku	NP_001019790.1	LRR 1	60..81		6/21 (29%)
		leucine-rich repeat	63..86	CDD:275380	7/23 (30%)
		LRR	<64..317	CDD:227223	85/400 (21%)
		LRR 2	86..107		8/20 (40%)
		leucine-rich repeat	87..110	CDD:275380	9/22 (41%)
		LRR 3	110..131		8/79 (10%)
		leucine-rich repeat	111..132	CDD:275380	8/79 (10%)
		LRR 4	133..154		7/34 (21%)
		leucine-rich repeat	134..186	CDD:275380	15/70 (21%)
		leucine-rich repeat	158..182	CDD:275380	5/23 (22%)
		LRR 5	160..180		5/19 (26%)
		LRR 6	186..207		6/20 (30%)
		leucine-rich repeat	187..205	CDD:275380	6/17 (35%)
		leucine-rich repeat	208..231	CDD:275380	10/22 (45%)
		LRR 7	208..228		9/19 (47%)
		LRR 8	231..253		7/35 (20%)
		leucine-rich repeat	232..256	CDD:275380	8/37 (22%)
		LRR 9	256..277		7/73 (10%)
		leucine-rich repeat	257..281	CDD:275380	9/46 (20%)
		LRR 10	281..302		6/20 (30%)
		leucine-rich repeat	282..305	CDD:275380	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910