DRSC/TRiP Functional Genomics Resources

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Protein Alignment rk and Lrrd1

DIOPT Version :9

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:NP_766467.2 Gene:Lrrd1 / 242838 MGIID:3045299 Length:853 Species:Mus musculus


Alignment Length:774 Identity:173/774 - (22%)
Similarity:304/774 - (39%) Gaps:173/774 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 PSAMGHDETKENPAPDMQN-SQEQEPYVHLQHLQQQQQQNP--QTVQQLSQIT--VNRTSKS--- 85
            |......|:.|.|..::.: ..|..||...:...|..:.||  .|.|..:..|  ::|..:.   
Mouse    10 PGGFPRFESLEEPGSEISDLLDEASPYSKSKDSNQIYEANPSKDTEQSAASFTSQLDRNEEKNTG 74

  Fly    86 --------ASVTPTGIRENVMLPSADPEKEAQILY------------------------------ 112
                    |.:.|..|.|::....:...|.|:..|                              
Mouse    75 IPFSETNIADIIPLSIEESLQSSGSSETKMAEDYYPVKFPTGRKFRGRIFNGNQKGLDMKSDNFT 139

  Fly   113 ----EKSLQEYHGSQLSTASTATDVIAGKRTLHSICERWLQKHCHCTG-----SLEVLRLSCRGI 168
                .|.|||:          ..|::..|...:...::...|:.....     .||:|.|...|:
Mouse   140 VNLDAKGLQEF----------PVDIVKVKYVKYLYLDKNQIKNFQGIDPGDLLGLEILSLQENGL 194

  Fly   169 GILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLS 233
            ..:.:.:.|.:.:.:|:...|.:::: ........|:.:|.|:.|.|..: |:....|..|:.||
Mouse   195 SSIPLEIQLFHNLKILNASYNEISQI-PKELLQLENMRQLLLNSNHIDTL-PSGLEHLRYLETLS 257

  Fly   234 LQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGL 298
            |.. .:.:..|.|...|..|..|.|..|.| ::....|..|.||.:|.|.||:...:| ..:..|
Mouse   258 LGK-NMLTYIPDSLSSLKNLRILNLEYNQL-TIFSKSLCFLPKLNSLNLTGNMIGSLP-KEVREL 319

  Fly   299 RTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLP 363
            :.||:|.:..|.||.:..|.| ::|.:..|.|..|::..||. .::|...|::|.||.||:.|:|
Mouse   320 KNLESLLMDHNKLTFLAVEIF-QLPKIKELHLADNKLEAISP-KIENFKELRLLNLDKNLLQSIP 382

  Fly   364 EGLSKLSQLQELSITSNRLRWINDTELP------RSMQMLDMRANPLSTIS-------------- 408
            :.:|....|:.||::.|     |..|||      ::::.|.:..|.:.|::              
Mouse   383 KKISHCVNLESLSLSDN-----NIEELPKKIRKLKNLRQLHVNRNKMITMTEEISHLSNIHILEF 442

  Fly   409 --------PGAFRGMSKLRKLILSDVRTLRSFP-ELEACHALEILKLDRAGIQEVPANLCRQTPR 464
                    |...:...|:.::.| :...:..|| .|.|..:|:.|..:...|.|:|.:: ..:.:
Mouse   443 SGNQITHVPIEIKNCRKITRVEL-NYNNIMYFPVGLCALQSLDYLSFNGNYISEIPVDM-SFSKQ 505

  Fly   465 LKSLELKTNSLKRI-PNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDA 528
            |..|||..|.|... .:|.|..:|..|||:.|||..|. ...:.:..|:.|:||.|:.::.|:: 
Mouse   506 LLHLELNRNKLTVFSKHLCSLTNLEYLDLAKNQIMTIP-SCISAMVSLHVLILSDNKFESFPKE- 568

  Fly   529 FQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPES--GLRAL--LHLKTFNNP 589
            ...:..|::||:..|::..|..| .|....::.|||.||||...|..  .|:.|  |::...:..
Mouse   569 LCSLKNLRVLDISENKLQKIPLE-ISKLKRIQKLNLSNNIFTNFPVELCQLQTLEELNISQTSGK 632

  Fly   590 KLREFPP---------------------PDTFPRIQTLILSYAYH------CCAFLPLVAMSSQK 627
            ||...|.                     |.....:::|:..||.:      ..:||.|..:.|  
Mouse   633 KLTRLPEEVSHMTQLKILNISNNAIKDIPKNIGELRSLVSFYASNNQISSLPSSFLSLEVLQS-- 695

  Fly   628 KTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEEQL 686
                              :.|..|:|..:...::.||     |:.:     |||::..|
Mouse   696 ------------------LDLRGNNMTALPSGIYKLS-----SLKE-----INFDDNPL 726

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380 6/20 (30%)
LRR_RI 180..>383 CDD:238064 59/202 (29%)
leucine-rich repeat 183..204 CDD:275380 2/20 (10%)
LRR_8 203..263 CDD:290566 18/59 (31%)
leucine-rich repeat 205..228 CDD:275380 6/22 (27%)
leucine-rich repeat 229..252 CDD:275380 7/22 (32%)
LRR_8 252..311 CDD:290566 19/58 (33%)
leucine-rich repeat 253..276 CDD:275380 7/22 (32%)
leucine-rich repeat 277..300 CDD:275380 7/22 (32%)
LRR_8 299..359 CDD:290566 20/59 (34%)
leucine-rich repeat 301..324 CDD:275380 8/22 (36%)
leucine-rich repeat 325..348 CDD:275380 6/22 (27%)
LRR_RI 327..567 CDD:238064 70/269 (26%)
leucine-rich repeat 349..371 CDD:275380 9/21 (43%)
LRR_8 370..425 CDD:290566 14/82 (17%)
leucine-rich repeat 372..393 CDD:275380 8/26 (31%)
leucine-rich repeat 394..415 CDD:275380 4/42 (10%)
leucine-rich repeat 418..486 CDD:275380 18/69 (26%)
leucine-rich repeat 441..464 CDD:275378 5/22 (23%)
LRR_8 487..545 CDD:290566 18/57 (32%)
leucine-rich repeat 487..510 CDD:275380 8/22 (36%)
leucine-rich repeat 511..534 CDD:275380 6/22 (27%)
LRR_8 533..589 CDD:290566 18/59 (31%)
leucine-rich repeat 535..558 CDD:275380 7/22 (32%)
leucine-rich repeat 559..580 CDD:275380 9/22 (41%)
7tm_4 764..>892 CDD:304433
7tm_1 770..1017 CDD:278431
Lrrd1NP_766467.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..78 14/67 (21%)
LRR 1 133..157 5/33 (15%)
leucine-rich repeat 139..159 CDD:275380 5/29 (17%)
LRR 2 159..180 1/20 (5%)
leucine-rich repeat 160..183 CDD:275380 1/22 (5%)
LRR_8 183..240 CDD:290566 12/57 (21%)
LRR 3 183..204 5/20 (25%)
leucine-rich repeat 184..206 CDD:275380 6/21 (29%)
LRR 4 206..227 2/21 (10%)
leucine-rich repeat 207..229 CDD:275380 2/22 (9%)
LRR 5 229..251 6/22 (27%)
leucine-rich repeat 230..252 CDD:275380 6/22 (27%)
LRR_8 251..309 CDD:290566 20/59 (34%)
LRR 6 252..274 6/22 (27%)
leucine-rich repeat 253..275 CDD:275380 7/22 (32%)
LRR 7 275..297 6/22 (27%)
leucine-rich repeat 276..298 CDD:275380 7/22 (32%)
LRR 8 298..319 7/21 (33%)
leucine-rich repeat 299..321 CDD:275380 7/22 (32%)
LRR_RI 315..582 CDD:238064 73/277 (26%)
LRR_8 320..378 CDD:290566 20/59 (34%)
LRR 9 321..342 8/21 (38%)
leucine-rich repeat 322..344 CDD:275380 8/22 (36%)
LRR 10 344..365 5/21 (24%)
leucine-rich repeat 345..367 CDD:275380 6/22 (27%)
LRR_8 366..424 CDD:290566 19/62 (31%)
LRR 11 367..388 9/20 (45%)
leucine-rich repeat 368..390 CDD:275380 9/21 (43%)
LRR 12 390..411 8/25 (32%)
leucine-rich repeat 391..436 CDD:275380 11/49 (22%)
LRR 13 413..435 3/21 (14%)
LRR 14 436..457 1/20 (5%)
LRR 15 459..481 6/22 (27%)
leucine-rich repeat 460..482 CDD:275380 5/22 (23%)
LRR_8 482..539 CDD:290566 18/57 (32%)
LRR 16 482..503 5/21 (24%)
leucine-rich repeat 483..505 CDD:275380 5/22 (23%)
LRR 17 505..527 8/21 (38%)
leucine-rich repeat 506..528 CDD:275380 8/21 (38%)
LRR 18 528..549 8/21 (38%)
LRR_8 551..606 CDD:290566 16/56 (29%)
LRR 19 551..573 6/22 (27%)
leucine-rich repeat 552..574 CDD:275380 6/22 (27%)
LRR_4 573..612 CDD:289563 14/39 (36%)
LRR 20 574..596 7/22 (32%)
leucine-rich repeat 575..597 CDD:275380 7/22 (32%)
LRR 21 597..618 8/20 (40%)
leucine-rich repeat 598..620 CDD:275380 9/21 (43%)
LRR 22 620..641 5/20 (25%)
leucine-rich repeat 621..646 CDD:275380 5/24 (21%)
LRR 23 646..668 1/21 (5%)
leucine-rich repeat 647..669 CDD:275380 1/21 (5%)
LRR 24 669..690 5/20 (25%)
leucine-rich repeat 670..692 CDD:275380 6/21 (29%)
LRR 25 692..713 4/40 (10%)
LRR 26 715..736 5/17 (29%)
leucine-rich repeat 716..736 CDD:275380 4/16 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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