DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Lrrc7

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001357710.1	Gene:	Lrrc7 / 242274	MGIID:	2676665	Length:	1575	Species:	Mus musculus

Alignment Length:	755	Identity:	173/755 - (22%)
Similarity:	268/755 - (35%)	Gaps:	234/755 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 NPAPDMQNSQEQEPYVHLQHLQQQQQQNPQTVQQLSQITVNRTSKSASVTPTGIRENVMLPSADP 104
            || |..|.|..:|....|       ::.|:...|..::|..|.....           ::|....
Mouse    10 NP-PQYQRSPCKEARAAL-------RKRPEEELQCLEMTTKRKLIGR-----------LVPCRCF 55

  Fly   105 EKEAQILYEKSLQEYHGSQLSTASTATDVIAGKRTLHSICERWLQKHCHCTGSLEVL---RLSCR 166
            ..|.:|:   |:.:|  |..|......:|...:|||.   |.:|.     ...:|.|   ..:|:
Mouse    56 RGEEEII---SVLDY--SHCSLQQVPKEVFNFERTLE---ELYLD-----ANQIEELPKQLFNCQ 107

  Fly   167 GIGILAVPVN----LPNEVV------VLDLGNNN-------------LTKLEA---------NSF 199
            .:..|::|.|    ||..:.      .||:..|.             ||.:||         :.|
Mouse   108 ALRKLSIPDNDLSSLPTSIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGF 172

  Fly   200 FMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALV 264
            ....||.:|.|:| :.:...|..|..|.||:.|.|:...||:| |:|...||||..|.|..|...
Mouse   173 TQLLNLTQLYLND-AFLEFLPANFGRLVKLRILELRENHLKTL-PKSMHKLAQLERLDLGNNEFS 235

  Fly   265 SLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLL 329
            .|. :.|..:|.||.|.::.|....:| .::..|:.|..|::..|.:..: |.|......|..||
Mouse   236 ELP-EVLDQIQNLRELWMDNNALQVLP-GSIGKLKMLVYLDMSKNRIETV-DMDISGCEALEDLL 297

  Fly   330 LKRNQIMKI--SAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPR 392
            |..|.:.::  |.|.||.||.|||   |||.::.||..:..||.|:|...:.|.|.     .||
Mouse   298 LSSNMLQQLPDSIGLLKKLTTLKV---DDNQLTMLPNTIGNLSLLEEFDCSCNELE-----SLP- 353

  Fly   393 SMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPAN 457
                                                    |.:...|:|..|.:|...:.|:|..
Mouse   354 ----------------------------------------PTIGYLHSLRTLAVDENFLPELPRE 378

  Fly   458 L--CRQTPRLKSLELKTNSLKRIP-NLSSCRDLRLLDLSSNQIEKIQGKPFN--GLKQLNDLLLS 517
            :  |:   .:..:.|::|.|:.:| .:...:.||:|:||.|:::.:   ||:  .||:|..|.||
Mouse   379 IGSCK---NVTVMSLRSNKLEFLPEEIGQMQRLRVLNLSDNRLKNL---PFSFTKLKELAALWLS 437

  Fly   518 YNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLH 582
            .|:.|||       ||    |..|.      |.|.       :...|.|.:||:.|.........
Mouse   438 DNQSKAL-------IP----LQTEA------HPET-------KQRVLTNYMFPQQPRGDEDFQSD 478

  Fly   583 LKTFNNPKLREFPPPDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMT 647
            ..:| ||.|.|                                :::..::..|..|....|.|.:
Mouse   479 SDSF-NPTLWE--------------------------------EQRQQRMTVAFEFEDKKEDDES 510

  Fly   648 L-----------WNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEE 701
            .           |:.....|..|...||    .....||...    ::|:|
Mouse   511 AGKVKALSCQAPWDRGQRGITLQPARLS----GDCCTPWARC----DQQIQ-------------- 553

  Fly   702 YFEEHDVSGPATGYGFGTGLFSGMSTEDFQPGSVQCLPMP 741
                 |:..|.:......|..||:..|     ...|.|:|
Mouse   554 -----DMPVPQSDPQLAWGCISGLQQE-----RSMCAPLP 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	7/27 (26%)
		LRR_RI	180..>383	CDD:238064	70/232 (30%)
		leucine-rich repeat	183..204	CDD:275380	8/42 (19%)
		LRR_8	203..263	CDD:290566	24/59 (41%)
		leucine-rich repeat	205..228	CDD:275380	7/22 (32%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		LRR_8	252..311	CDD:290566	17/58 (29%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		LRR_8	299..359	CDD:290566	22/61 (36%)
		leucine-rich repeat	301..324	CDD:275380	5/22 (23%)
		leucine-rich repeat	325..348	CDD:275380	10/24 (42%)
		LRR_RI	327..567	CDD:238064	63/246 (26%)
		leucine-rich repeat	349..371	CDD:275380	9/21 (43%)
		LRR_8	370..425	CDD:290566	7/54 (13%)
		leucine-rich repeat	372..393	CDD:275380	6/20 (30%)
		leucine-rich repeat	394..415	CDD:275380	0/20 (0%)
		leucine-rich repeat	418..486	CDD:275380	12/70 (17%)
		leucine-rich repeat	441..464	CDD:275378	6/24 (25%)
		LRR_8	487..545	CDD:290566	22/59 (37%)
		leucine-rich repeat	487..510	CDD:275380	9/24 (38%)
		leucine-rich repeat	511..534	CDD:275380	9/22 (41%)
		LRR_8	533..589	CDD:290566	11/55 (20%)
		leucine-rich repeat	535..558	CDD:275380	4/22 (18%)
		leucine-rich repeat	559..580	CDD:275380	5/20 (25%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Lrrc7	NP_001357710.1	leucine-rich repeat	64..85	CDD:275380	4/22 (18%)
		LRR_8	85..140	CDD:338972	14/62 (23%)
		leucine-rich repeat	86..108	CDD:275380	6/29 (21%)
		leucine-rich repeat	109..131	CDD:275380	5/21 (24%)
		LRR	130..440	CDD:227223	99/369 (27%)
		leucine-rich repeat	132..177	CDD:275380	8/44 (18%)
		leucine-rich repeat	178..200	CDD:275380	7/22 (32%)
		leucine-rich repeat	201..223	CDD:275380	9/22 (41%)
		leucine-rich repeat	224..246	CDD:275380	6/22 (27%)
		leucine-rich repeat	247..269	CDD:275380	6/22 (27%)
		leucine-rich repeat	270..292	CDD:275380	5/22 (23%)
		leucine-rich repeat	316..336	CDD:275380	10/22 (45%)
		leucine-rich repeat	339..361	CDD:275380	7/67 (10%)
		leucine-rich repeat	362..384	CDD:275380	6/24 (25%)
		leucine-rich repeat	385..407	CDD:275380	4/21 (19%)
		leucine-rich repeat	408..430	CDD:275380	9/24 (38%)
		PDZ_signaling	1485..1570	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910