DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rk and FLRT3

DIOPT Version :9

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:NP_037413.1 Gene:FLRT3 / 23767 HGNCID:3762 Length:649 Species:Homo sapiens


Alignment Length:580 Identity:130/580 - (22%)
Similarity:207/580 - (35%) Gaps:180/580 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 PTGIRENVMLPSADPEKEAQILYEKSLQEYHGSQLSTASTATDVIAGKRTLHSICERWLQKHCHC 154
            ||||.|           :|..||   ||   .:|::.|...:|:                     
Human    53 PTGIPE-----------DATTLY---LQ---NNQINNAGIPSDL--------------------- 79

  Fly   155 TGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSI--IN 217
            ...|:|.|:......:...|.|||..|..|.|..||:..:..:|....|.||||.|.|||:  ::
Human    80 KNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVS 144

  Fly   218 MDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRL 282
            ::..||.....|:.|.|....|.::|                           .|..:.:..|||
Human   145 IEEGAFRDSNYLRLLFLSRNHLSTIP---------------------------WGLPRTIEELRL 182

  Fly   283 EGNLFYRIPTNALAGLRTLEALNLGSNLLTI--INDEDFPRMPNLIVLLLKRNQIMKISAGALKN 345
            :.|....|.:.:|.||.:|:.|.|..|||..  :.|:.|..:.||..|.|.||.:    ..|..|
Human   183 DDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSL----TAAPVN 243

  Fly   346 L--TALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTIS 408
            |  |.|:.|.|.||.|:.:|               .|...::      |.:..|||..|.||.:.
Human   244 LPGTNLRKLYLQDNHINRVP---------------PNAFSYL------RQLYRLDMSNNNLSNLP 287

  Fly   409 PGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPAN------LCRQTPRLKS 467
            .|.|..:..:.:||      ||:.|....|.    :|..|..:|.:|..      :|:...:::.
Human   288 QGIFDDLDNITQLI------LRNNPWYCGCK----MKWVRDWLQSLPVKVNVRGLMCQAPEKVRG 342

  Fly   468 LELKTNSLKRIPNLSSCRD------LRLLDLSSNQIEKIQGK---PFNGLKQLNDLLLSYNR--- 520
            :.:|..:.:    |..|:|      :::.....|.:...||:   |......:.:..|:.:.   
Human   343 MAIKDLNAE----LFDCKDSGIVSTIQITTAIPNTVYPAQGQWPAPVTKQPDIKNPKLTKDHQTT 403

  Fly   521 -----------IKALPQDAFQGIPKLQLLDLEGNEISYI---HKEAFSGFT-------------- 557
                       :|::..|......|| .|.:....:|::   |..||...|              
Human   404 GSPSRKTITITVKSVTSDTIHISWKL-ALPMTALRLSWLKLGHSPAFGSITETIVTGERSEYLVT 467

  Fly   558 -------------ALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFPRIQ 604
                         .:|..||  .:|.|.|       :.::|...| ||.:.|..|..|.|
Human   468 ALEPDSPYKVCMVPMETSNL--YLFDETP-------VCIETETAP-LRMYNPTTTLNREQ 517

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380 6/20 (30%)
LRR_RI 180..>383 CDD:238064 57/208 (27%)
leucine-rich repeat 183..204 CDD:275380 5/20 (25%)
LRR_8 203..263 CDD:290566 16/61 (26%)
leucine-rich repeat 205..228 CDD:275380 10/24 (42%)
leucine-rich repeat 229..252 CDD:275380 5/22 (23%)
LRR_8 252..311 CDD:290566 13/58 (22%)
leucine-rich repeat 253..276 CDD:275380 1/22 (5%)
leucine-rich repeat 277..300 CDD:275380 8/22 (36%)
LRR_8 299..359 CDD:290566 23/63 (37%)
leucine-rich repeat 301..324 CDD:275380 8/24 (33%)
leucine-rich repeat 325..348 CDD:275380 8/24 (33%)
LRR_RI 327..567 CDD:238064 58/300 (19%)
leucine-rich repeat 349..371 CDD:275380 7/21 (33%)
LRR_8 370..425 CDD:290566 12/54 (22%)
leucine-rich repeat 372..393 CDD:275380 1/20 (5%)
leucine-rich repeat 394..415 CDD:275380 8/20 (40%)
leucine-rich repeat 418..486 CDD:275380 14/73 (19%)
leucine-rich repeat 441..464 CDD:275378 5/28 (18%)
LRR_8 487..545 CDD:290566 10/74 (14%)
leucine-rich repeat 487..510 CDD:275380 4/25 (16%)
leucine-rich repeat 511..534 CDD:275380 3/36 (8%)
LRR_8 533..589 CDD:290566 15/85 (18%)
leucine-rich repeat 535..558 CDD:275380 7/52 (13%)
leucine-rich repeat 559..580 CDD:275380 6/20 (30%)
7tm_4 764..>892 CDD:304433
7tm_1 770..1017 CDD:278431
FLRT3NP_037413.1 LRRNT 31..61 CDD:214470 5/18 (28%)
Interaction with ADGRL3. /evidence=ECO:0000269|PubMed:26235030 38..67 10/30 (33%)
LRR 1. /evidence=ECO:0000255 59..80 8/47 (17%)
leucine-rich repeat 61..84 CDD:275378 7/49 (14%)
LRR 2. /evidence=ECO:0000255 84..104 5/19 (26%)
leucine-rich repeat 85..104 CDD:275380 5/18 (28%)
LRR 3. /evidence=ECO:0000255 105..126 6/20 (30%)
LRR_8 106..166 CDD:290566 20/59 (34%)
leucine-rich repeat 106..129 CDD:275380 6/22 (27%)
LRR_RI <120..259 CDD:238064 49/169 (29%)
LRR 4. /evidence=ECO:0000255 129..150 8/20 (40%)
leucine-rich repeat 130..155 CDD:275380 10/24 (42%)
LRR 5. /evidence=ECO:0000255 155..175 6/46 (13%)
leucine-rich repeat 156..176 CDD:275380 6/46 (13%)
LRR_8 175..237 CDD:290566 22/61 (36%)
LRR 6. /evidence=ECO:0000255 176..197 6/20 (30%)
leucine-rich repeat 177..200 CDD:275380 8/22 (36%)
LRR 7. /evidence=ECO:0000255 200..220 7/19 (37%)
leucine-rich repeat 201..226 CDD:275380 8/24 (33%)
LRR 8. /evidence=ECO:0000255 226..247 9/24 (38%)
leucine-rich repeat 227..248 CDD:275380 8/24 (33%)
LRR_8 247..306 CDD:290566 22/85 (26%)
LRR_4 247..287 CDD:289563 16/60 (27%)
LRR 9. /evidence=ECO:0000255 248..269 8/35 (23%)
leucine-rich repeat 249..272 CDD:275380 8/43 (19%)
LRR 10. /evidence=ECO:0000255 272..293 8/20 (40%)
leucine-rich repeat 273..296 CDD:275380 8/22 (36%)
LRRCT 305..356 CDD:214507 9/58 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 387..407 1/19 (5%)
fn3 413..478 CDD:278470 10/65 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 622..649
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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