DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rk and DNAAF11

DIOPT Version :9

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:XP_006716601.2 Gene:DNAAF11 / 23639 HGNCID:16725 Length:472 Species:Homo sapiens


Alignment Length:263 Identity:64/263 - (24%)
Similarity:104/263 - (39%) Gaps:69/263 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   465 LKSLELKTNSLKRIPNLSS-CRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDA 528
            |:.|.|....::|:.::.. ||||::|.|.:|.|.||:.  .:.||:|..|.|:.|.|:.:  :.
Human    29 LEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIEN--VSKLKKLEYLNLALNNIEKI--EN 89

  Fly   529 FQGIPKLQLLDLEGN---EISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLK---TFN 587
            .:|..:|..|||..|   |:|.|.             ||.:||             |||   ...
Human    90 LEGCEELAKLDLTVNFIGELSSIK-------------NLQHNI-------------HLKELFLMG 128

  Fly   588 NP-----KLREFPPPDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQE-AVLFPS--DAEF 644
            ||     ..|||... |.|:::            :|....:...::...:|: :|:.|.  :.|.
Human   129 NPCASFDHYREFVVA-TLPQLK------------WLDGKEIEPSERIKALQDYSVIEPQIREQEK 180

  Fly   645 DMTLWNNSMMNIWPQMH-----NLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFE 704
            |..|....:.....:.|     |..|:..|.....|.|.||.....|:::...|...:      |
Human   181 DHCLKRAKLKEEAQRKHQEEDKNEDKRSNAGFDGRWYTDINATLSSLESKDHLQAPDT------E 239

  Fly   705 EHD 707
            ||:
Human   240 EHN 242

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380
LRR_RI 180..>383 CDD:238064
leucine-rich repeat 183..204 CDD:275380
LRR_8 203..263 CDD:290566
leucine-rich repeat 205..228 CDD:275380
leucine-rich repeat 229..252 CDD:275380
LRR_8 252..311 CDD:290566
leucine-rich repeat 253..276 CDD:275380
leucine-rich repeat 277..300 CDD:275380
LRR_8 299..359 CDD:290566
leucine-rich repeat 301..324 CDD:275380
leucine-rich repeat 325..348 CDD:275380
LRR_RI 327..567 CDD:238064 32/105 (30%)
leucine-rich repeat 349..371 CDD:275380
LRR_8 370..425 CDD:290566
leucine-rich repeat 372..393 CDD:275380
leucine-rich repeat 394..415 CDD:275380
leucine-rich repeat 418..486 CDD:275380 5/21 (24%)
leucine-rich repeat 441..464 CDD:275378
LRR_8 487..545 CDD:290566 20/60 (33%)
leucine-rich repeat 487..510 CDD:275380 8/22 (36%)
leucine-rich repeat 511..534 CDD:275380 6/22 (27%)
LRR_8 533..589 CDD:290566 15/61 (25%)
leucine-rich repeat 535..558 CDD:275380 8/25 (32%)
leucine-rich repeat 559..580 CDD:275380 4/20 (20%)
7tm_4 764..>892 CDD:304433
7tm_1 770..1017 CDD:278431
DNAAF11XP_006716601.2 LRR_RI <5..200 CDD:238064 52/213 (24%)
leucine-rich repeat 29..51 CDD:275378 5/21 (24%)
LRR_8 52..104 CDD:290566 19/55 (35%)
LRR_4 52..92 CDD:289563 14/43 (33%)
leucine-rich repeat 52..73 CDD:275378 8/22 (36%)
leucine-rich repeat 74..95 CDD:275378 6/22 (27%)
leucine-rich repeat 96..120 CDD:275378 12/49 (24%)
LRRcap 134..152 CDD:197729 5/30 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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