DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and PHLPP1

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_919431.2	Gene:	PHLPP1 / 23239	HGNCID:	20610	Length:	1717	Species:	Homo sapiens

Alignment Length:	814	Identity:	162/814 - (19%)
Similarity:	267/814 - (32%)	Gaps:	286/814 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PSAMGHDETKENPAPDMQNSQEQEPYVHLQHLQQQQQQNPQTVQQLSQITVNRTSK---SASVTP 90
            |...||   ...|.|..|.:...:|          ||:.|:.:..........:.:   :|:|.|
Human   394 PRRPGH---PAQPLPLPQTASSPQP----------QQKAPRAIDSPGGAVREGSCEEKAAAAVAP 445

  Fly    91 TGI-----RENVMLPSADPEKEAQILY--------------EKSLQ------------------- 117
            .|:     |..|....|.|......||              ||.||
Human   446 GGLQSTPGRSGVTAEKAPPPPPPPTLYVQLHGETTRRLEAEEKPLQIQNDYLFQLGFGELWRVQE 510

  Fly   118 ------------EYHGSQLSTASTATDVIAG-----KRTLHSICERW------------------ 147
                        .|.|...||.|:....::|     |..:.....||
Human   511 EGMDSEIGCLIRFYAGKPHSTGSSERIQLSGMYNVRKGKMQLPVNRWTRRQVILCGTCLIVSSVK 575

  Fly   148 -------------------LQKHCHCTG-----------------SLEVLRLSCRGIGILAVPVN 176
                               ::||.||..                 ..|.||. .|.:..:|
Human   576 DSLTGKMHVLPLIGGKVEEVKKHQHCLAFSSSGPQSQTYYICFDTFTEYLRW-LRQVSKVA---- 635

  Fly   177 LPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDP--------NAFYGLAKLKRLS 233
             ...:..:||...:|..|.||.|: :.:|..|.|..| .:..:|        |......|||.|:
Human   636 -SQRISSVDLSCCSLEHLPANLFY-SQDLTHLNLKQN-FLRQNPSLPAARGLNELQRFTKLKSLN 697

  Fly   234 LQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGL 298
            |.|..|... |.:...:..|..|.::.|||.|:.. .:|.:..|:|..|:||....:|.. |..:
Human   698 LSNNHLGDF-PLAVCSIPTLAELNVSCNALRSVPA-AVGVMHNLQTFLLDGNFLQSLPAE-LENM 759

  Fly   299 RTLEALNLGSNLLTIIND-----------------------EDFPRMPNLIVLLLKRNQIMKISA 340
            :.|..|.|..|..|.|.:                       :...:||::..:.|:.|.|.|:.|
Human   760 KQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIA 824

  Fly   341 GALKNLTALKVLELDDN-------------------------------LISSLPEGLSKLSQ--- 371
            ..:..|..:..|:|.||                               .:.:|....::|.|
Human   825 DEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLDICGYFLKALYASSNELVQLDV 889

  Fly   372 ------LQELSITSNRL----RWINDTELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDV 426
                  |..:.::.|||    .|:.::   |.:::||:..|.:..: |......|.|||| |:..
Human   890 YPVPNYLSYMDVSRNRLENVPEWVCES---RKLEVLDIGHNQICEL-PARLFCNSSLRKL-LAGH 949

  Fly   427 RTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSL---------------- 475
            ..|...||.....::|:|.:....:.|:|.||..:...|:.|....|.|
Human   950 NQLARLPERLERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSIL 1014

  Fly   476 ------------KRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQ-- 526
                        |.:|.|:....|::|.::.|:::.........|::|.::.||.|::||:|.
Human  1015 QELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTI 1079

  Fly   527 ----------------DAF---QGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPEL 572
                            :.|   ..:|:::.:||..||:|              ::.|..|:.|:|
Human  1080 MNCRRMHTVIAHSNCIEVFPEVMQLPEIKCVDLSCNELS--------------EVTLPENLPPKL 1130

  Fly   573 PESGL----RALLHLKT---FNNPKLREFPPPDT 599
            .|..|    |.:|..||   .||.:..:...|.|
Human  1131 QELDLTGNPRLVLDHKTLELLNNIRCFKIDQPST 1164

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	5/20 (25%)
		LRR_RI	180..>383	CDD:238064	60/277 (22%)
		leucine-rich repeat	183..204	CDD:275380	7/20 (35%)
		LRR_8	203..263	CDD:290566	17/67 (25%)
		leucine-rich repeat	205..228	CDD:275380	6/30 (20%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..311	CDD:290566	18/58 (31%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		LRR_8	299..359	CDD:290566	18/113 (16%)
		leucine-rich repeat	301..324	CDD:275380	7/45 (16%)
		leucine-rich repeat	325..348	CDD:275380	6/22 (27%)
		LRR_RI	327..567	CDD:238064	64/332 (19%)
		leucine-rich repeat	349..371	CDD:275380	6/52 (12%)
		LRR_8	370..425	CDD:290566	17/67 (25%)
		leucine-rich repeat	372..393	CDD:275380	5/24 (21%)
		leucine-rich repeat	394..415	CDD:275380	4/20 (20%)
		leucine-rich repeat	418..486	CDD:275380	21/95 (22%)
		leucine-rich repeat	441..464	CDD:275378	6/22 (27%)
		LRR_8	487..545	CDD:290566	16/78 (21%)
		leucine-rich repeat	487..510	CDD:275380	4/22 (18%)
		leucine-rich repeat	511..534	CDD:275380	8/43 (19%)
		LRR_8	533..589	CDD:290566	17/62 (27%)
		leucine-rich repeat	535..558	CDD:275380	5/22 (23%)
		leucine-rich repeat	559..580	CDD:275380	7/24 (29%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
PHLPP1	NP_919431.2	leucine-rich repeat	1107..1129	CDD:275380	7/35 (20%)
		PP2Cc	1168..1420	CDD:214625
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1458..1510
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1673..1717
		PDZ-binding, required for interaction with SLC9A3R1. /evidence=ECO:0000269\|PubMed:21804599	1715..1717
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..118
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..156
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..470		18/88 (20%)
		PH_PHLPP-like	535..631	CDD:270131	12/96 (13%)
		PH	555..636	CDD:278594	11/86 (13%)
		LRR_RI	625..929	CDD:238064	69/317 (22%)
		LRR_8	638..703	CDD:290566	19/66 (29%)
		LRR 1	638..659		7/21 (33%)
		leucine-rich repeat	641..661	CDD:275380	7/20 (35%)
		LRR 2	661..682		5/21 (24%)
		leucine-rich repeat	662..692	CDD:275380	6/30 (20%)
		LRR 3	692..712		8/20 (40%)
		leucine-rich repeat	693..738	CDD:275380	14/46 (30%)
		LRR_8	714..770	CDD:290566	17/57 (30%)
		LRR 4	715..736		7/21 (33%)
		LRR 5	738..760		7/22 (32%)
		leucine-rich repeat	739..761	CDD:275380	7/22 (32%)
		LRR 6	761..783		6/21 (29%)
		leucine-rich repeat	762..784	CDD:275380	6/21 (29%)
		LRR 7	784..804		0/19 (0%)
		leucine-rich repeat	785..808	CDD:275380	1/22 (5%)
		LRR 8	808..831		5/22 (23%)
		leucine-rich repeat	810..832	CDD:275380	6/21 (29%)
		LRR_RI	814..1074	CDD:238064	53/264 (20%)
		LRR 9	832..853		4/20 (20%)
		leucine-rich repeat	833..853	CDD:275380	4/19 (21%)
		leucine-rich repeat	854..895	CDD:275380	3/40 (8%)
		LRR 10	873..894		3/20 (15%)
		LRR 11	895..916		5/20 (25%)
		leucine-rich repeat	896..918	CDD:275380	5/24 (21%)
		LRR 12	918..939		4/21 (19%)
		leucine-rich repeat	919..941	CDD:275380	4/22 (18%)
		LRR 13	941..962		8/21 (38%)
		leucine-rich repeat	942..963	CDD:275380	8/21 (38%)
		LRR_8	962..1024	CDD:290566	10/61 (16%)
		LRR 14	963..984		6/20 (30%)
		leucine-rich repeat	964..987	CDD:275380	6/22 (27%)
		LRR 15	987..1008		4/20 (20%)
		leucine-rich repeat	988..1011	CDD:275380	4/22 (18%)
		LRR 16	1013..1033		2/19 (11%)
		LRR_8	1014..1072	CDD:290566	11/57 (19%)
		leucine-rich repeat	1014..1037	CDD:275380	3/22 (14%)
		LRR 17	1037..1058		3/20 (15%)
		leucine-rich repeat	1038..1061	CDD:275380	4/22 (18%)
		LRR 18	1061..1082		7/20 (35%)
		Interaction with SLC9A3R1. /evidence=ECO:0000269\|PubMed:21804599	1076..1205		22/103 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910