DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Tshr

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_035778.3	Gene:	Tshr / 22095	MGIID:	98849	Length:	764	Species:	Mus musculus

Alignment Length:	725	Identity:	233/725 - (32%)
Similarity:	349/725 - (48%)	Gaps:	121/725 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   371 QLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLR----- 430
            |..:..:|...|..|  ..||.|.|.|.:....|.||...||..:..:.::.||...||:
Mouse    33 QEDDFRVTCKELHRI--PSLPPSTQTLKLIETHLKTIPSLAFSSLPNISRIYLSIDATLQRLEPH 95

  Fly   431 SFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSS------------ 483
            ||..|.....:||  .:...:..:..:...:.|.||.|.:....|:..|:|:.
Mouse    96 SFYNLSKMTHIEI--RNTRSLTYIDPDALTELPLLKFLGIFNTGLRIFPDLTKIYSTDIFFILEI 158

  Fly   484 -----------------CRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNR-IKALPQDAFQ 530
                             |.:...|.|.:|....:||..|||.| |:.:.|:.|: :.|:..|||.
Mouse   159 TDNPYMTSVPENAFQGLCNETLTLKLYNNGFTSVQGHAFNGTK-LDAVYLNKNKYLTAIDNDAFG 222

  Fly   531 GIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFP 595
            |:                    :||.|.|:   :.:.....||..||..|..|...:...|::.|
Mouse   223 GV--------------------YSGPTLLD---VSSTSVTALPSKGLEHLKELIAKDTWTLKKLP 264

  Fly   596 PPDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQM 660
            ...:|..:....|||..|||||      .:|||...:.|::           :.|.|      .:
Mouse   265 LSLSFLHLTRADLSYPSHCCAF------KNQKKIRGILESL-----------MCNES------SI 306

  Fly   661 HNLSKQLGASM----------HDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGY 715
            .||.::...::          .||.:.::.:.:.....::.   :.|:...:|||.:    ....
Mouse   307 RNLRQRKSVNILRGPIYQEYEEDPGDNSVGYKQNSKFQESP---SNSHYYVFFEEQE----DEVV 364

  Fly   716 GFGTGLFSGMSTEDFQP-------------GSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLS 767
            |||..| .....|..|.             ..:.|.|....|.||.|:..:..||..||.|.||:
Mouse   365 GFGQEL-KNPQEETLQAFESHYDYTVCGDNEDMVCTPKSDEFNPCEDIMGYRFLRIVVWFVSLLA 428

  Fly   768 LLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVL 832
            ||||..|:.:||.|..|:.|||||:||||.|||.||:||.::|.||..|..|:...||.||....
Mouse   429 LLGNIFVLLILLTSHYKLTVPRFLMCNLAFADFCMGVYLLLIASVDLYTHSEYYNHAIDWQTGPG 493

  Fly   833 CQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLV 897
            |..:||..|.:||||||||.||||||.||||.|:.|::::.|:.|..||:.|||...::||:|:|
Mouse   494 CNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHAYTIMAGGWVSCFLLALLPMV 558

  Fly   898 GVSDYRKFAVCLPFETTTGPASLTYVISLMFINGCAFLTLMGCYLKMYWAIRGSQAWN--TNDSR 960
            |:|.|.|.::|||.:|.| |.:|.|::.::.:|..||:.:..||:|:|..:|..| :|  ..|::
Mouse   559 GISSYAKVSICLPMDTDT-PLALAYIVLVLLLNVVAFVVVCSCYVKIYITVRNPQ-YNPRDKDTK 621

  Fly   961 IAKRMALLVFTDFLCWSPIAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFK 1025
            ||||||:|:||||:|.:||:|::::|:....||::..:||..|...|||||.|||||||.||.|:
Mouse   622 IAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKILLVLFYPLNSCANPFLYAIFTKAFQ 686

  Fly  1026 KDCVTLCKHF 1035
            :|...|...|
Mouse   687 RDVFILLSKF 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	2/11 (18%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064	52/230 (23%)
		leucine-rich repeat	349..371	CDD:275380	233/725 (32%)
		LRR_8	370..425	CDD:290566	15/53 (28%)
		leucine-rich repeat	372..393	CDD:275380	5/20 (25%)
		leucine-rich repeat	394..415	CDD:275380	7/20 (35%)
		leucine-rich repeat	418..486	CDD:275380	17/101 (17%)
		leucine-rich repeat	441..464	CDD:275378	2/22 (9%)
		LRR_8	487..545	CDD:290566	17/58 (29%)
		leucine-rich repeat	487..510	CDD:275380	8/22 (36%)
		leucine-rich repeat	511..534	CDD:275380	8/23 (35%)
		LRR_8	533..589	CDD:290566	10/55 (18%)
		leucine-rich repeat	535..558	CDD:275380	2/22 (9%)
		leucine-rich repeat	559..580	CDD:275380	5/20 (25%)
		7tm_4	764..>892	CDD:304433	67/127 (53%)
		7tm_1	770..1017	CDD:278431	119/248 (48%)
Tshr	NP_035778.3	leucine-rich repeat	54..77	CDD:275380	7/22 (32%)
		LRR_5	65..221	CDD:290045	35/158 (22%)
		leucine-rich repeat	78..102	CDD:275380	7/23 (30%)
		LRR 1	100..124		3/25 (12%)
		leucine-rich repeat	103..127	CDD:275380	2/25 (8%)
		LRR 2	125..150		7/24 (29%)
		leucine-rich repeat	128..152	CDD:275380	6/23 (26%)
		LRR 3	151..174		0/22 (0%)
		leucine-rich repeat	153..177	CDD:275380	0/23 (0%)
		LRR 4	176..199		7/22 (32%)
		leucine-rich repeat	181..201	CDD:275380	8/19 (42%)
		LRR 5	200..223		8/23 (35%)
		leucine-rich repeat	202..226	CDD:275380	8/43 (19%)
		LRR 6	225..248		8/25 (32%)
		LRR 7	264..288		10/29 (34%)
		7tm_4	423..>556	CDD:304433	70/132 (53%)
		7tm_1	431..678	CDD:278431	119/248 (48%)
		PDZ-binding	762..764
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810