DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Lrrc1

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_030100078.1	Gene:	Lrrc1 / 214345	MGIID:	2442313	Length:	580	Species:	Mus musculus

Alignment Length:	402	Identity:	106/402 - (26%)
Similarity:	177/402 - (44%)	Gaps:	70/402 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 VLDLGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSF 247
            |.|...|.||:|                         |.:|..|..|..||:.:..|:|| |::.
Mouse   165 VADFSGNPLTRL-------------------------PESFPELQNLTCLSVNDISLQSL-PENI 203

  Fly   248 QGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLT 312
            ..|..|.||:|..|.|..|. |.|..|::|..|.|..|..|.:| .::..|..|:.|.|..|.|:
Mouse   204 GNLYNLASLELRENLLTYLP-DSLTQLRRLEELDLGNNEIYNLP-ESIGALLHLKDLWLDGNQLS 266

  Fly   313 IINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSI 377
            .: .::...:.||:.|.:..|::.::.. .:..||:|..|.:..||:.::|||:.||.:|..|.:
Mouse   267 EL-PQEIGNLKNLLCLDVSENRLERLPE-EISGLTSLTYLVISQNLLETIPEGIGKLKKLSILKL 329

  Fly   378 TSNRLRWINDTELP------RSMQMLDMRANPLSTISPGAFRGMSKLRKL--ILSDVRTLRSFP- 433
            ..|||     |:||      .::..|.:..|.|.|:.    :.:.||:||  :.:|...|.|.|
Mouse   330 DQNRL-----TQLPEAIGDCENLTELVLTENRLLTLP----KSIGKLKKLSNLNADRNKLVSLPK 385

  Fly   434 ELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQ-- 496
            |:..|.:|.:..:....:..:||.: .|...|..|::..|.|..:|...:...|:.|.||.||
Mouse   386 EIGGCCSLTMFCIRDNRLTRLPAEV-SQAVELHVLDVAGNRLHHLPLSLTTLKLKALWLSDNQSQ 449

  Fly   497 --------IEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISY----IH 549
                    |::..|:     |.|..:||.....:.:.|::......|:.|..:.:|.::    :|
Mouse   450 PLLTFQTDIDRATGE-----KILTCVLLPQMPSEPICQESLPRCGALESLVTDMSEEAWNDRSVH 509

  Fly   550 KEAFSGFTALED 561
            :  .|....|||
Mouse   510 R--VSAIRFLED 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	58/199 (29%)
		leucine-rich repeat	183..204	CDD:275380	6/20 (30%)
		LRR_8	203..263	CDD:290566	16/59 (27%)
		leucine-rich repeat	205..228	CDD:275380	3/22 (14%)
		leucine-rich repeat	229..252	CDD:275380	8/22 (36%)
		LRR_8	252..311	CDD:290566	21/58 (36%)
		leucine-rich repeat	253..276	CDD:275380	10/22 (45%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		LRR_8	299..359	CDD:290566	14/59 (24%)
		leucine-rich repeat	301..324	CDD:275380	5/22 (23%)
		leucine-rich repeat	325..348	CDD:275380	4/22 (18%)
		LRR_RI	327..567	CDD:238064	65/258 (25%)
		leucine-rich repeat	349..371	CDD:275380	9/21 (43%)
		LRR_8	370..425	CDD:290566	16/62 (26%)
		leucine-rich repeat	372..393	CDD:275380	8/26 (31%)
		leucine-rich repeat	394..415	CDD:275380	4/20 (20%)
		leucine-rich repeat	418..486	CDD:275380	18/70 (26%)
		leucine-rich repeat	441..464	CDD:275378	4/22 (18%)
		LRR_8	487..545	CDD:290566	15/67 (22%)
		leucine-rich repeat	487..510	CDD:275380	8/32 (25%)
		leucine-rich repeat	511..534	CDD:275380	4/22 (18%)
		LRR_8	533..589	CDD:290566	8/33 (24%)
		leucine-rich repeat	535..558	CDD:275380	5/26 (19%)
		leucine-rich repeat	559..580	CDD:275380	3/3 (100%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Lrrc1	XP_030100078.1	PRK12323	<4..>158	CDD:237057
		LRR	146..446	CDD:227223	89/320 (28%)
		leucine-rich repeat	163..185	CDD:275380	9/44 (20%)
		leucine-rich repeat	186..208	CDD:275380	8/22 (36%)
		leucine-rich repeat	209..231	CDD:275380	10/22 (45%)
		leucine-rich repeat	232..254	CDD:275380	7/22 (32%)
		leucine-rich repeat	255..277	CDD:275380	5/22 (23%)
		leucine-rich repeat	278..300	CDD:275380	4/22 (18%)
		leucine-rich repeat	301..346	CDD:275380	17/49 (35%)
		leucine-rich repeat	347..369	CDD:275380	6/25 (24%)
		leucine-rich repeat	370..392	CDD:275380	7/21 (33%)
		leucine-rich repeat	416..437	CDD:275380	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910