DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and fshr

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001001812.1	Gene:	fshr / 195820	ZFINID:	ZDB-GENE-020423-5	Length:	668	Species:	Danio rerio

Alignment Length:	662	Identity:	220/662 - (33%)
Similarity:	321/662 - (48%)	Gaps:	103/662 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   390 LPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEV 454
            :|.:...::::...:|.....|...:.:|:::::|:...|.   .:||.....:.:|:...|.:
Zfish    51 IPTNTTFVEIKLTQISVFRRAALSELHELKRIVVSENGALE---RIEALAFFNLTELEEITITK- 111

  Fly   455 PANLCR------QTPRLKSLELKTNSLKRIPNLSSCRDLR---LLDLSSN-QIEKIQGKPFNGLK 509
            ..||..      :.|:|:.|.:....||.:|:.|......   |.||..| .||:|....|.||.
Zfish   112 SKNLVMHKDAFWRLPKLRYLTISNTGLKILPDFSKINSAALEFLFDLQDNMHIERIPSNAFLGLT 176

  Fly   510 Q--LNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGN-EISYIHKEAFSGFTALEDLNLGNNIFPE 571
            .  :.:|.|:.|.|:.:...||.| .|:..|.|.|| ::::||..||.|......|::.......
Zfish   177 NATITELRLTKNGIREIDSHAFNG-TKIGKLFLMGNQQLNHIHSYAFKGAEGPVVLDISRTAVHT 240

  Fly   572 LPESGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAV 636
            ||||.|:.|..|...:...||:.|..:.|..:....|:|..|||||      .:.||...|:
Zfish   241 LPESMLKTLKLLMAVSVYSLRKLPSLELFTELTQANLTYPSHCCAF------KNFKKHKSVK--- 296

  Fly   637 LFPSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEE 701
                          |.|.|:                                 ||......:. .
Zfish   297 --------------NQMCNV---------------------------------TGAHEEPDFF-N 313

  Fly   702 YFEEH--DVSGPATGYGFGTGLFSGMSTEDFQPGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVF 764
            :|.:|  ||.                        .|.|.|.|..|.||.|:..:..||..:|.:.
Zfish   314 FFNDHCKDVI------------------------EVTCYPTPDAFNPCEDIMGFTFLRVLIWFIS 354

  Fly   765 LLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQM 829
            :|:::||..|:.|||.||.|:.|||||:|:||.||..|||||.::|.||..|...:..:.|.||.
Zfish   355 VLAIVGNTVVLLVLLTSRYKLTVPRFLMCHLAFADLCMGIYLLLIAAVDIHTQSRYYNYGIDWQT 419

  Fly   830 SVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALM 894
            ...|.::||..|.|||||||||..|||||.:.||:|:.|.:::.|:.|..:|:.||:|:|:.|||
Zfish   420 GAGCHVAGFFTVFSSELSVYTLTAITLERWHTITYAMQLERQMRLRHACLVMATGWLFSLLAALM 484

  Fly   895 PLVGVSDYRKFAVCLPFETTTGPASLTYVISLMFINGCAFLTLMGCYLKMYWAIRGSQAWNTN-D 958
            |:.|||.|.|.::|||.:..| ..|..||:.|:.:|..|||.:..||..:|..:|.......| |
Zfish   485 PMFGVSSYSKTSICLPMDVET-LLSQGYVVLLLLLNAAAFLVVCVCYTLIYLTVRNPAFVPANAD 548

  Fly   959 SRIAKRMALLVFTDFLCWSPIAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQ 1023
            .|||||||:|:||||||.:||:||:|:|.|.|.||:...||:..|...|:|||.||||||..||.
Zfish   549 MRIAKRMAVLIFTDFLCMAPISFFAISAAFKLPLITASHAKVLLVLFYPINSCSNPFLYAFFTKT 613

  Fly  1024 FKKDCVTLCKHF 1035
            ||:|...|...|
Zfish   614 FKRDFFILTSRF 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064	47/189 (25%)
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566	4/34 (12%)
		leucine-rich repeat	372..393	CDD:275380	1/2 (50%)
		leucine-rich repeat	394..415	CDD:275380	2/20 (10%)
		leucine-rich repeat	418..486	CDD:275380	16/73 (22%)
		leucine-rich repeat	441..464	CDD:275378	4/28 (14%)
		LRR_8	487..545	CDD:290566	22/64 (34%)
		leucine-rich repeat	487..510	CDD:275380	10/26 (38%)
		leucine-rich repeat	511..534	CDD:275380	7/22 (32%)
		LRR_8	533..589	CDD:290566	18/56 (32%)
		leucine-rich repeat	535..558	CDD:275380	9/23 (39%)
		leucine-rich repeat	559..580	CDD:275380	6/20 (30%)
		7tm_4	764..>892	CDD:304433	61/127 (48%)
		7tm_1	770..1017	CDD:278431	121/247 (49%)
fshr	NP_001001812.1	leucine-rich repeat	79..103	CDD:275380	5/26 (19%)
		LRR_5	93..224	CDD:290045	39/132 (30%)
		leucine-rich repeat	104..127	CDD:275380	4/23 (17%)
		leucine-rich repeat	128..151	CDD:275380	6/22 (27%)
		leucine-rich repeat	152..177	CDD:275380	10/24 (42%)
		leucine-rich repeat	180..202	CDD:275380	7/22 (32%)
		leucine-rich repeat	203..227	CDD:275380	9/23 (39%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		leucine-rich repeat	252..274	CDD:275380	5/21 (24%)
		7tm_1	360..607	CDD:278431	121/247 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	249	1.000	Domainoid score	I2091
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810