DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Mtnr1b

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001380770.1	Gene:	Mtnr1b / 192646	RGDID:	620798	Length:	364	Species:	Rattus norvegicus

Alignment Length:	382	Identity:	90/382 - (23%)
Similarity:	156/382 - (40%)	Gaps:	68/382 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   723 SGMSTEDFQPGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLS----------LLGNGTVVFV 777
            ||::.....|||.:..|...|..|              ||..:||          .:||..|:..
  Rat    14 SGLAARPSWPGSAEAEPPETPRAP--------------WVAPMLSTVVIVTTAVDFVGNLLVILS 64

  Fly   778 LLCSRSKMDVPRFLVCNLAAADFFMGIY---LGILAIV-DAATLGEFRMFAIPWQMSVLCQLSGF 838
            :|.:|...:.....|.|||.||..:.:|   |.::||: |...|||           :.|:.|.|
  Rat    65 VLRNRKLRNAGNLFVVNLALADLVVALYPYPLILVAILHDGWVLGE-----------IHCKASAF 118

  Fly   839 LAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMP--LVGVSD 901
            :..||...||:.:..|.:.|.:.|.|:...::..|...|...:|:.|:..|: ||:|  .||..:
  Rat   119 VMGLSVIGSVFNITAIAINRYWCICHSATYHRACSQWHAPLYISLIWLLTLV-ALVPNFFVGSLE 182

  Fly   902 YRKFAVCLPFETTTGPASLTYVISLMFINGCAFLTLMGCYLKMYWAIRGSQAWNTNDSRIAKRMA 966
            |........|..|........|:::.|:...|.::.  |||:::..:..::.....:.::..|.:
  Rat   183 YDPRIYSCTFIQTASTQYTMAVVAIHFLLPIAVVSF--CYLRIWILVLQARRKAKAERKLRLRPS 245

  Fly   967 LL--------VFTDF-LCWSPIAFFSITAIFGLQLISL---EQAKIFTVFVLPLNSCCNPFLYAI 1019
            .|        ||..| :||:|:....:......:.::|   |...:.:.|:...|||.|..:|.:
  Rat   246 DLRSFLTMFAVFVVFAICWAPLNCIGLAVAINPEAMALQIPEGLFVTSYFLAYFNSCLNAIVYGL 310

  Fly  1020 MTKQFKKDCVTLCKHFEESRVVGGGGPGGRGAVARTK---RGDLPPPLLPAAAVAHP 1073
            :.:.|::         |..|::......||.....:|   ..||..|:.|||....|
  Rat   311 LNQNFRR---------EYKRILSALWSTGRCFHDASKCHLTEDLQGPVPPAAMATIP 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	37/141 (26%)
		7tm_1	770..1017	CDD:278431	64/264 (24%)
Mtnr1b	NP_001380770.1	7tm_GPCRs	41..319	CDD:421689	68/300 (23%)
		TM helix 1	42..68	CDD:410628	6/25 (24%)
		TM helix 2	75..100	CDD:410628	8/24 (33%)
		TM helix 3	113..143	CDD:410628	9/29 (31%)
		TM helix 4	155..177	CDD:410628	7/22 (32%)
		TM helix 5	197..226	CDD:410628	6/30 (20%)
		TM helix 6	244..274	CDD:410628	7/29 (24%)
		TM helix 7	287..312	CDD:410628	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910