DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and tkr-1

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_499064.2	Gene:	tkr-1 / 192055	WormBaseID:	WBGene00006576	Length:	406	Species:	Caenorhabditis elegans

Alignment Length:	296	Identity:	61/296 - (20%)
Similarity:	122/296 - (41%)	Gaps:	48/296 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   760 VWVVFLL----SLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEF 820
            |.:.|:|    :::||..|::::...:.......:.:.|:|.||.       ::|:.:..|...:
Worm    46 VAIAFVLLMATAIIGNSVVMWIIYQHKVMHYGFNYFLFNMAFADL-------LIALFNVGTSWTY 103

  Fly   821 RMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKR-LSLKQAGYIMSVG 884
            .:: ..|....||.|:.|..:..:.:||.::..::.:|..|:.:.  |.|| ||.|::...:.:.
Worm   104 NLY-YDWWYGDLCTLTSFFGIAPTTVSVCSMMALSWDRCQAVVNP--LQKRPLSRKRSVIAILII 165

  Fly   885 WVFALIMALMPLVGVSDYRKFAVCLPFETTTGPASLTYVISLMFINGCAFLTLMGCYLKMYWAIR 949
            ||.:.:.||...:..|....:.    ::..|...|..:|.|.. :|......|.|....:...|.
Worm   166 WVVSTVTALPFAIAASVNSLYT----YDVVTSTVSKAHVCSAP-VNTFFEKVLFGIQYALPIIIL 225

  Fly   950 GSQAWN-------TND--------------SRIAKRMALLVFTDFLCWSPIAFFSITAIFGL-QL 992
            ||....       ||:              |:..|.:.|:|....:||.|   :.|...|.| :.
Worm   226 GSTFTRIAVAFRATNEATDSSLKNNHTRAKSKAVKMLFLMVVAFVVCWLP---YHIYHAFALEEF 287

  Fly   993 ISLEQAK--IFTVFVLPLNSCC-NPFLYAIMTKQFK 1025
            ....:.|  ...::.:.::||. ||.:|....::|:
Worm   288 FDAARGKYAYLLIYWIAMSSCAYNPIIYCFANERFR 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	28/132 (21%)
		7tm_1	770..1017	CDD:278431	56/272 (21%)
tkr-1	NP_499064.2	7tm_4	58..330	CDD:304433	58/284 (20%)
tkr-1	NP_499064.2	7tm_1	60..315	CDD:278431	56/272 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910