DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and lron-12

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001366666.1	Gene:	lron-12 / 190700	WormBaseID:	WBGene00013542	Length:	398	Species:	Caenorhabditis elegans

Alignment Length:	366	Identity:	79/366 - (21%)
Similarity:	139/366 - (37%)	Gaps:	63/366 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDN-SI 215
            |.|....:  :::|.|..::.:|..||:....|.:.|:::..:|.|||.....|.::...:| ::
Worm    38 CQCDEDKQ--QVTCEGQQVVTLPDRLPSGYESLVIRNSSVRTIEKNSFRKMEKLMQIEFENNPNL 100

  Fly   216 INMDPNAFYGLAKLKRLSLQNC-GLKSLPPQSFQGLAQLTSLQL--NGNALVSLDGDCLGHLQKL 277
            ..::..||.||.|::.:....| ||..|...:|.|:.....|::  ....:..:||....:.|.:
Worm   101 GTIEKLAFKGLKKIRLIKFTTCPGLTELQKNAFSGIQNQMGLKIIFEKTPIHRIDGHTFRNAQNI 165

  Fly   278 RTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGA 342
            |.|.:.|                 |.|.|..:....||..||          |..:.::.|....
Worm   166 RELTISG-----------------EELALSRHCFANINQLDF----------LTVSGVVLIEPEI 203

  Fly   343 LKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELP--RSMQMLDMRANPLS 405
            ..|.|...|:...::.....|...|.||....|.|..:::..|......  .::|::::.|..|.
Worm   204 FTNSTRFHVVHFKNSQFDIPPSTFSTLSHTSHLLIEHSKVPSIAPDAFSGLTTIQVIELHACQLG 268

  Fly   406 TISPGAFRGMSKLRKL-----ILSDVRTLRSFPELEACHALEILKLD-------RAGIQEV-PAN 457
            |||..||..:..|.:|     .:.|:.|..|.........:|...|:       ...::|: ..|
Worm   269 TISARAFANVENLGELKILRNTIGDLDTSESIMSRALKTRIEENTLECSCGMKWMTSVEEMSDIN 333

  Fly   458 LCRQTPRLKS---------------LELKTNSLKRIPNLSS 483
            .|..|...:|               :..|||.|..|.:.||
Worm   334 FCSTTASFRSIRSFIKAKCLNPSQEISRKTNHLPSISSFSS 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	4/20 (20%)
		LRR_RI	180..>383	CDD:238064	44/206 (21%)
		leucine-rich repeat	183..204	CDD:275380	6/20 (30%)
		LRR_8	203..263	CDD:290566	14/63 (22%)
		leucine-rich repeat	205..228	CDD:275380	6/23 (26%)
		leucine-rich repeat	229..252	CDD:275380	6/23 (26%)
		LRR_8	252..311	CDD:290566	10/60 (17%)
		leucine-rich repeat	253..276	CDD:275380	3/24 (13%)
		leucine-rich repeat	277..300	CDD:275380	3/22 (14%)
		LRR_8	299..359	CDD:290566	12/59 (20%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..348	CDD:275380	3/22 (14%)
		LRR_RI	327..567	CDD:238064	39/187 (21%)
		leucine-rich repeat	349..371	CDD:275380	4/21 (19%)
		LRR_8	370..425	CDD:290566	14/61 (23%)
		leucine-rich repeat	372..393	CDD:275380	3/22 (14%)
		leucine-rich repeat	394..415	CDD:275380	8/20 (40%)
		leucine-rich repeat	418..486	CDD:275380	19/94 (20%)
		leucine-rich repeat	441..464	CDD:275378	6/30 (20%)
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
lron-12	NP_001366666.1	leucine-rich repeat	45..67	CDD:275380	5/23 (22%)
		LRR_5	66..184	CDD:404228	29/134 (22%)
		leucine-rich repeat	68..88	CDD:275380	6/19 (32%)
		leucine-rich repeat	89..113	CDD:275380	6/23 (26%)
		leucine-rich repeat	114..138	CDD:275380	6/23 (26%)
		leucine-rich repeat	139..164	CDD:275380	3/24 (13%)
		leucine-rich repeat	165..187	CDD:275380	7/38 (18%)
		leucine-rich repeat	188..209	CDD:275380	5/30 (17%)
		leucine-rich repeat	210..232	CDD:275380	4/21 (19%)
		LRR_8	<221..267	CDD:404697	9/45 (20%)
		leucine-rich repeat	233..256	CDD:275380	3/22 (14%)
		leucine-rich repeat	257..277	CDD:275380	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910