DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and npr-22

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001023541.1	Gene:	npr-22 / 190424	WormBaseID:	WBGene00022004	Length:	434	Species:	Caenorhabditis elegans

Alignment Length:	356	Identity:	76/356 - (21%)
Similarity:	135/356 - (37%)	Gaps:	124/356 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   762 VVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIP 826
            ::.:..:.||..|:.|::..:........|:.|||.||..:.:                  |.||
Worm    59 ILCVCCVYGNVLVILVIVYFKRLRTATNILILNLAVADLLISV------------------FCIP 105

  Fly   827 ---WQM-----------SVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQA 877
               ||:           |::|.|..||..::..||.:||.||:.:|..||...:..|.|::.::|
Worm   106 FSYWQVLIYDDQRWLFGSMMCSLLAFLQAMAVFLSAWTLVVISFDRWMAIMFLLTPNIRITRRRA 170

  Fly   878 GYIMSVGWVFALIMALMPLVGVSDYRKFAVCLPFETTTG----PASLTY---------------V 923
            .|:::..|:|:::||| ||:..:.:        ||...|    ..:.||               |
Worm   171 LYLVAATWIFSILMAL-PLLFTTRF--------FEDQDGLPNCGENWTYFGDSGEQVRKVYSSMV 226

  Fly   924 ISLMFINGCAFLTLMGCYLKMYWAIRGSQAWNT---------NDSRIAKR---------MALLVF 970
            :.|.::...|.|.:...::       |.:.||:         ....|..|         |.:|:.
Worm   227 LILQYVVPQAVLIITYTHI-------GIKMWNSRVPGMQNGATKKMIVDRHESVKKLVPMVILIS 284

  Fly   971 TDF-LCWSPI--------AFFSITAIFGLQLISLEQAKIFTVFVLPL----------NSCCNPFL 1016
            ..| |||.|:        .|:.....:|              ::|.|          :|..||.:
Worm   285 ALFALCWLPLLILINVIPEFYPDINSWG--------------YILYLWWFAHGLAMSHSMVNPII 335

  Fly  1017 YAIMTKQFKKD-C-----VTLCKHFEESRVV 1041
            |.|...:|::. |     :..|..|:|.|::
Worm   336 YFIRNARFREGFCFFSSKLLPCISFKELRLL 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	35/141 (25%)
		7tm_1	770..1017	CDD:278431	68/316 (22%)
npr-22	NP_001023541.1	7tmA_PR4-like	51..347	CDD:320514	71/335 (21%)
		TM helix 1	52..78	CDD:320514	4/18 (22%)
		TM helix 2	85..110	CDD:320514	9/42 (21%)
		TM helix 3	126..156	CDD:320514	12/29 (41%)
		TM helix 4	169..190	CDD:320514	9/21 (43%)
		TM helix 5	219..248	CDD:320514	5/35 (14%)
		TM helix 6	271..301	CDD:320514	7/29 (24%)
		TM helix 7	315..340	CDD:320514	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910