DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and iglr-1

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_510491.2	Gene:	iglr-1 / 184720	WormBaseID:	WBGene00008977	Length:	695	Species:	Caenorhabditis elegans

Alignment Length:	634	Identity:	128/634 - (20%)
Similarity:	226/634 - (35%)	Gaps:	181/634 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CHCTGS---------------LEVLRLSCRGIGILAVPVNLPNEVVVLDLGN------NNLTKLE 195
            |.|..|               ||||:.|         |.|...::.:..:.|      .::.||.
Worm    26 CSCNESSISCTFLTKPELYVFLEVLKDS---------PFNETTDLSLASIDNFWLRMLPDMPKLR 81

  Fly   196 ANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNG 260
            ......:|:|      |:|...:..|.|   .:|:.|..:||.||:. |::...|..|..|.|:.
Worm    82 VLKVQSSPSL------DDSDWFLRRNQF---PELQTLHFKNCSLKTF-PKALMALTSLLELDLSD 136

  Fly   261 NALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNL 325
            |.|.:|..|.: |::.::.:.|..|....|..:....:.||:.|:|..|.:|.:...||....:|
Worm   137 NMLENLGADSI-HIRSIQRVILRNNQIKSIGVHVFRYMPTLKMLDLSGNNMTRLVTSDFTSAVSL 200

  Fly   326 IVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTEL 390
            ..|:|:.|:|..|.....:.:..|:.|:|..||:|.:     :|...|..
Worm   201 RELILRENKIELIETDTTEPMQQLETLDLSGNLLSEV-----RLEAQQNF--------------- 245

  Fly   391 PRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVP 455
             |.:..|::..|||..|..|..:                  .|:      |::|:||...|..|.
Worm   246 -RHLFSLNLSCNPLQIIREGFLQ------------------LPD------LQVLQLDNCNISVVE 285

  Fly   456 ANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNR 520
            |......|||.|:::|.|     |||:........:.::.....||...|
Worm   286 AGAFVSLPRLHSMDIKDN-----PNLAYFSPYAFSNNTAFYRMNIQNSGF--------------- 330

  Fly   521 IKALPQDAFQGIPKLQLLDLEGNEI----SYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALL 581
             |.:|....:   |:..|.::|.::    :....:.:...|.::    .|:...:.....::.|.
Worm   331 -KRIPLTILE---KISQLYIKGTQLDCSCTSRDMQDYGAITIVD----WNDATCKTKIGAVQKLS 387

  Fly   582 HLKTFNNPKLREFPPPDTFPRIQTLILSYAYHCC-------------------AFLPLVAMSSQK 627
            ||:....|.......|....:..|:..||..:|.                   |..|.:..||.|
Worm   388 HLEKTGEPCRDNLLTPFGIRQTATVGHSYRIYCANDGTNSKLLWISPNKTTIEASHPKLRKSSDK 452

  Fly   628 KTSQVQEAVLFPSDAE--------------FDMTLWNNS-------------------MMNIWPQ 659
            :|......:|.||.:.              ||:.|.|::                   :..:.|.
Worm   453 RTDYFTTTLLDPSFSRNHEERIHISNEYYGFDVVLENDAGHYECVSKSDMKTITRKIELEVVKPN 517

  Fly   660 MH-NLSKQLGASMHDPWETAINFNEEQLQTQTGGQIA---TSYMEEYFE 704
            :: |.|.....|:|      :|:| ..|:.:...::|   |:..|:.|:
Worm   518 IYLNASHVATTSVH------LNWN-RNLKIEAVDRVALRITASSEKMFK 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	7/20 (35%)
		LRR_RI	180..>383	CDD:238064	50/208 (24%)
		leucine-rich repeat	183..204	CDD:275380	3/26 (12%)
		LRR_8	203..263	CDD:290566	18/59 (31%)
		leucine-rich repeat	205..228	CDD:275380	5/22 (23%)
		leucine-rich repeat	229..252	CDD:275380	8/22 (36%)
		LRR_8	252..311	CDD:290566	16/58 (28%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	3/22 (14%)
		LRR_8	299..359	CDD:290566	18/59 (31%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..348	CDD:275380	6/22 (27%)
		LRR_RI	327..567	CDD:238064	46/243 (19%)
		leucine-rich repeat	349..371	CDD:275380	7/21 (33%)
		LRR_8	370..425	CDD:290566	8/54 (15%)
		leucine-rich repeat	372..393	CDD:275380	1/20 (5%)
		leucine-rich repeat	394..415	CDD:275380	6/20 (30%)
		leucine-rich repeat	418..486	CDD:275380	17/67 (25%)
		leucine-rich repeat	441..464	CDD:275378	7/22 (32%)
		LRR_8	487..545	CDD:290566	8/57 (14%)
		leucine-rich repeat	487..510	CDD:275380	3/22 (14%)
		leucine-rich repeat	511..534	CDD:275380	2/22 (9%)
		LRR_8	533..589	CDD:290566	8/59 (14%)
		leucine-rich repeat	535..558	CDD:275380	2/26 (8%)
		leucine-rich repeat	559..580	CDD:275380	1/20 (5%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
iglr-1	NP_510491.2	LRR	<104..325	CDD:227223	65/272 (24%)
		leucine-rich repeat	106..128	CDD:275380	8/22 (36%)
		leucine-rich repeat	129..151	CDD:275380	8/22 (36%)
		leucine-rich repeat	152..175	CDD:275380	3/22 (14%)
		leucine-rich repeat	176..199	CDD:275380	7/22 (32%)
		leucine-rich repeat	200..223	CDD:275380	6/22 (27%)
		leucine-rich repeat	224..247	CDD:275380	8/43 (19%)
		leucine-rich repeat	248..270	CDD:275380	6/39 (15%)
		leucine-rich repeat	271..294	CDD:275380	7/22 (32%)
		leucine-rich repeat	295..316	CDD:275380	7/25 (28%)
		leucine-rich repeat	320..343	CDD:275380	6/41 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910