DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and lron-1

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_510424.4	Gene:	lron-1 / 181553	WormBaseID:	WBGene00008093	Length:	607	Species:	Caenorhabditis elegans

Alignment Length:	484	Identity:	130/484 - (26%)
Similarity:	214/484 - (44%)	Gaps:	87/484 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 VIAGKRTLHSICER-WLQKHCHCTGS-LEVLRLSCRGIGIL-AVPVNLPNEVVVLDLGNNNLTKL 194
            :|||  .::|.|.. .||:.|.||.: .|.:.::|.|...| ||..:|.|....:|
Worm     9 LIAG--WVYSQCPTLQLQEPCTCTSTRYEAVSINCDGGSSLDAVLESLSNSPQAID--------- 62

  Fly   195 EANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQ--LTSLQ 257
                        .||:|:..|..|...||.|. ::|:|.|:|.||:|..|.:|.|..:  |..|:
Worm    63 ------------SLTISNTPIEKMPGYAFQGF-QIKKLFLRNNGLRSFHPNTFTGNLENSLEELE 114

  Fly   258 LNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEA---LNLGSNLLTIINDEDF 319
            :.||.:..:....:..|::|:.|.|..||...:..||.....:.::   |:|.:|.||.|:....
Worm   115 IRGNYIDGIPQSGVSILKQLKILSLPDNLIEYVQDNAFLSYHSRDSLLKLDLSANNLTAIHPTGL 179

  Fly   320 PRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRW 384
            ..:.||..|.|.:|.:.:|.:.||:|:.:|:.|.|..|.|.::......|..|:.||:..|::|.
Worm   180 LGLENLSQLSLDKNLLSEIPSQALENIPSLEDLSLGVNRIHTISRNSLPLPNLKSLSLEVNQIRL 244

  Fly   385 I-----NDTELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEIL 444
            |     ::|.|   :..|.:..|.|::|....|..:..|:.|.:|:.:.:.|           |.
Worm   245 IPSDSFSETPL---LSYLYLGNNLLTSIDASMFLHIGGLKVLSMSNNKDITS-----------IQ 295

  Fly   445 KLDRAGIQEVPANLC----RQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPF 505
            ...:..:|:....:|    :..|.|..|||...|:.||              ....::|:|
Worm   296 ANGKLSVQQFKLCICILAFQHAPSLIRLELFDCSISRI--------------EPKSLQKVQ---- 342

  Fly   506 NGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFP 570
                .:..:|||.|:|..:..|.|..:|:|..|||.||.|:.:...|||....|..|:|.:|...
Worm   343 ----HIQVILLSRNQITRISHDTFSNLPELSELDLSGNSINAVDDFAFSQLPMLTSLDLSSNRLE 403

  Fly   571 ELPESGL-RALLHLKTF---------NNP 589
            .||.:.: .:|:..||.         |||
Worm   404 SLPSNVIYDSLMQKKTSPVQRKLSIQNNP 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	7/21 (33%)
		LRR_RI	180..>383	CDD:238064	56/207 (27%)
		leucine-rich repeat	183..204	CDD:275380	1/20 (5%)
		LRR_8	203..263	CDD:290566	22/61 (36%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		leucine-rich repeat	229..252	CDD:275380	10/22 (45%)
		LRR_8	252..311	CDD:290566	15/63 (24%)
		leucine-rich repeat	253..276	CDD:275380	5/22 (23%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		LRR_8	299..359	CDD:290566	19/62 (31%)
		leucine-rich repeat	301..324	CDD:275380	6/25 (24%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		LRR_RI	327..567	CDD:238064	64/248 (26%)
		leucine-rich repeat	349..371	CDD:275380	6/21 (29%)
		LRR_8	370..425	CDD:290566	15/59 (25%)
		leucine-rich repeat	372..393	CDD:275380	8/25 (32%)
		leucine-rich repeat	394..415	CDD:275380	5/20 (25%)
		leucine-rich repeat	418..486	CDD:275380	15/71 (21%)
		leucine-rich repeat	441..464	CDD:275378	3/26 (12%)
		LRR_8	487..545	CDD:290566	16/57 (28%)
		leucine-rich repeat	487..510	CDD:275380	2/22 (9%)
		leucine-rich repeat	511..534	CDD:275380	7/22 (32%)
		LRR_8	533..589	CDD:290566	21/65 (32%)
		leucine-rich repeat	535..558	CDD:275380	10/22 (45%)
		leucine-rich repeat	559..580	CDD:275380	6/21 (29%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
lron-1	NP_510424.4	PRK15370	<58..>289	CDD:185268	68/255 (27%)
		leucine-rich repeat	85..109	CDD:275380	10/23 (43%)
		leucine-rich repeat	110..133	CDD:275380	5/22 (23%)
		leucine-rich repeat	134..157	CDD:275380	7/22 (32%)
		leucine-rich repeat	161..184	CDD:275380	6/22 (27%)
		leucine-rich repeat	185..208	CDD:275380	8/22 (36%)
		leucine-rich repeat	209..231	CDD:275380	6/21 (29%)
		leucine-rich repeat	232..255	CDD:275380	7/22 (32%)
		leucine-rich repeat	256..279	CDD:275380	5/22 (23%)
		leucine-rich repeat	280..319	CDD:275380	7/49 (14%)
		leucine-rich repeat	320..343	CDD:275380	9/44 (20%)
		LRR_8	343..402	CDD:338972	22/58 (38%)
		leucine-rich repeat	344..367	CDD:275380	7/22 (32%)
		leucine-rich repeat	368..391	CDD:275380	10/22 (45%)
		leucine-rich repeat	392..410	CDD:275380	6/17 (35%)
		leucine-rich repeat	414..435	CDD:275378	6/19 (32%)
		LRRCT	431..>472	CDD:214507	2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910