DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rk and Nmbr

DIOPT Version :9

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:NP_032729.1 Gene:Nmbr / 18101 MGIID:1100525 Length:390 Species:Mus musculus


Alignment Length:353 Identity:74/353 - (20%)
Similarity:134/353 - (37%) Gaps:75/353 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   728 EDFQPGS--------VQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSK 784
            :||.|.|        ::|: :|..:|                ::..:.||||..:|.:.|.:.:.
Mouse    27 KDFLPDSDGTTAELVIRCV-IPSLYL----------------IIISVGLLGNIMLVKIFLTNSAM 74

  Fly   785 MDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVL-CQLSGFLAVLSSELSV 848
            .:||...:.||||.|        :|.::....:...|.|...|....| |:|...:.:.|..:||
Mouse    75 RNVPNIFISNLAAGD--------LLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSV 131

  Fly   849 YTLAVITLERNYAITHAIHLNKR-----LSLKQAGYIMSVGWVFALIMAL-------MPLVGVSD 901
            :||..::.:|..||.:.:.:...     .|||..|.     ||.::::|:       :..:|..|
Mouse   132 FTLTALSADRYRAIVNPMDMQTSGVLLWTSLKAVGI-----WVVSVLLAVPEAVFSEVARIGSLD 191

  Fly   902 YRKFAVCLPFETTTGPASLTYVISLMFINGCAFLTLMGCY--------LKMYWAIRGSQAWNTND 958
            ...|..|:|:..|.......:.:.:..:.....|.::..|        :|....:.|....:|..
Mouse   192 NSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIKSAHNLPGEYNEHTKK 256

  Fly   959 -----SRIAKRMALLVFTDFLCWSPIAFFSITAIFGLQLISLEQAKIFTVFVLPL----NSCCNP 1014
                 .|:||.:.:.|.....||.|.....:...|..:.|......:....|..:    |||.||
Mouse   257 QMETRKRLAKIVLVFVGCFVFCWFPNHVLYLYRSFNYKEIDPSLGHMIVTLVARVLSFSNSCVNP 321

  Fly  1015 FLYAIMTKQFKKDCVTLCKHFEESRVVG 1042
            |...::::.|:       |||......|
Mouse   322 FALYLLSESFR-------KHFNSQLCCG 342

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380
LRR_RI 180..>383 CDD:238064
leucine-rich repeat 183..204 CDD:275380
LRR_8 203..263 CDD:290566
leucine-rich repeat 205..228 CDD:275380
leucine-rich repeat 229..252 CDD:275380
LRR_8 252..311 CDD:290566
leucine-rich repeat 253..276 CDD:275380
leucine-rich repeat 277..300 CDD:275380
LRR_8 299..359 CDD:290566
leucine-rich repeat 301..324 CDD:275380
leucine-rich repeat 325..348 CDD:275380
LRR_RI 327..567 CDD:238064
leucine-rich repeat 349..371 CDD:275380
LRR_8 370..425 CDD:290566
leucine-rich repeat 372..393 CDD:275380
leucine-rich repeat 394..415 CDD:275380
leucine-rich repeat 418..486 CDD:275380
leucine-rich repeat 441..464 CDD:275378
LRR_8 487..545 CDD:290566
leucine-rich repeat 487..510 CDD:275380
leucine-rich repeat 511..534 CDD:275380
LRR_8 533..589 CDD:290566
leucine-rich repeat 535..558 CDD:275380
leucine-rich repeat 559..580 CDD:275380
7tm_4 764..>892 CDD:304433 34/133 (26%)
7tm_1 770..1017 CDD:278431 60/276 (22%)
NmbrNP_032729.1 7tm_1 60..322 CDD:278431 58/274 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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