DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and lron-2

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_505402.1	Gene:	lron-2 / 179309	WormBaseID:	WBGene00022789	Length:	575	Species:	Caenorhabditis elegans

Alignment Length:	483	Identity:	117/483 - (24%)
Similarity:	195/483 - (40%)	Gaps:	98/483 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 ATDVIAGKRTLHSICERWLQKHCHCTGSL-EVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTK 193
            ||.|:    |::..|.. |...|.|..|: |.:.:.|:..|      :|.|.:..:....:
Worm     9 ATLVV----TVYGQCPA-LSGACRCAPSVYEPVAIICQNAG------SLQNAIQAIQAARD---- 58

  Fly   194 LEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQG--LAQLTSL 256
                    .| ::.||:.|.:|..:..|||.....| ||.|....|:::..|:|.|  |..|..|
Worm    59 --------IP-IDSLTILDTAIPTIPANAFQSFTIL-RLVLNRNTLQNIDDQAFNGPLLDSLIEL 113

  Fly   257 QLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPT---NALAGLRTLEALNLGSNLLTIINDED 318
            .||.|.|..:....:..|:.||.|.|..|...::.:   ||......|..|.|..|.||.....|
Worm   114 DLNDNNLGQIPQTGIPRLRNLRKLYLNRNRINQLSSTAFNAFESRDLLLKLELAGNRLTDATLGD 178

  Fly   319 FPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEG--LSKLSQLQELSITSNR 381
                                 |...:.||.|:.|.|:.|.::|:|..  :::.:.|..|::..|.
Worm   179 ---------------------ATVFRPLTLLQELSLETNSLTSIPSSALVNQRNTLTNLNLGLNS 222

  Fly   382 LRWINDTELPRS------MQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHA 440
            :     .|:|..      :..|.:..|.::.|.|.||:|:..|:.|.:    |...||.......
Worm   223 I-----NEVPVGALDFPVLSSLSLEFNGITVIPPQAFQGVPNLQFLYM----TGNKFPSWAPEMF 278

  Fly   441 LEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPF 505
            ..|.:|...||.|.|.::           :..|:...||||     :| |::|...::.|:...|
Worm   279 RYITQLKTLGIGETPISV-----------IPNNAFMHIPNL-----IR-LEMSEAAVDTIERGAF 326

  Fly   506 NGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFP 570
            ....|:..::|:.||:..:..|.|:|:..|..:||:||.|..:....|:...|:..|::..|:..
Worm   327 QRTPQIQAIVLNKNRLSQVRADFFEGLNDLYSIDLQGNRIDNVQPLGFANLPAISHLDISYNLLQ 391

  Fly   571 ELPESGLRALLHLKTFNNPKLREFPPPD 598
            .:|.:         .|.|..|   |.|:
Worm   392 TMPSN---------VFQNSFL---PQPN 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	4/21 (19%)
		LRR_RI	180..>383	CDD:238064	50/209 (24%)
		leucine-rich repeat	183..204	CDD:275380	0/20 (0%)
		LRR_8	203..263	CDD:290566	22/61 (36%)
		leucine-rich repeat	205..228	CDD:275380	7/22 (32%)
		leucine-rich repeat	229..252	CDD:275380	9/24 (38%)
		LRR_8	252..311	CDD:290566	18/61 (30%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	7/25 (28%)
		LRR_8	299..359	CDD:290566	14/59 (24%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..348	CDD:275380	2/22 (9%)
		LRR_RI	327..567	CDD:238064	58/247 (23%)
		leucine-rich repeat	349..371	CDD:275380	6/23 (26%)
		LRR_8	370..425	CDD:290566	14/60 (23%)
		leucine-rich repeat	372..393	CDD:275380	5/20 (25%)
		leucine-rich repeat	394..415	CDD:275380	6/20 (30%)
		leucine-rich repeat	418..486	CDD:275380	16/67 (24%)
		leucine-rich repeat	441..464	CDD:275378	6/22 (27%)
		LRR_8	487..545	CDD:290566	17/57 (30%)
		leucine-rich repeat	487..510	CDD:275380	5/22 (23%)
		leucine-rich repeat	511..534	CDD:275380	6/22 (27%)
		LRR_8	533..589	CDD:290566	12/55 (22%)
		leucine-rich repeat	535..558	CDD:275380	7/22 (32%)
		leucine-rich repeat	559..580	CDD:275380	3/20 (15%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
lron-2	NP_505402.1	leucine-rich repeat	64..84	CDD:275380	7/19 (37%)
		leucine-rich repeat	85..109	CDD:275380	9/24 (38%)
		LRR_8	86..144	CDD:290566	20/57 (35%)
		LRR_RI	109..294	CDD:238064	52/214 (24%)
		leucine-rich repeat	110..133	CDD:275380	7/22 (32%)
		LRR_8	132..198	CDD:290566	21/86 (24%)
		leucine-rich repeat	134..157	CDD:275380	7/22 (32%)
		leucine-rich repeat	161..187	CDD:275380	9/46 (20%)
		leucine-rich repeat	188..211	CDD:275380	6/22 (27%)
		LRR_8	212..270	CDD:290566	15/66 (23%)
		leucine-rich repeat	213..235	CDD:275380	5/26 (19%)
		leucine-rich repeat	236..259	CDD:275380	7/22 (32%)
		leucine-rich repeat	260..283	CDD:275380	6/26 (23%)
		LRR_8	282..342	CDD:290566	18/76 (24%)
		leucine-rich repeat	284..307	CDD:275380	7/33 (21%)
		leucine-rich repeat	308..355	CDD:275380	13/52 (25%)
		LRR_8	330..390	CDD:290566	17/59 (29%)
		leucine-rich repeat	356..377	CDD:275380	7/20 (35%)
		leucine-rich repeat	380..400	CDD:275380	4/28 (14%)
		Ca_hom_mod	<481..>504	CDD:291464
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910