DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rk and soc-2

DIOPT Version :9

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:NP_001293758.1 Gene:soc-2 / 177286 WormBaseID:WBGene00004929 Length:631 Species:Caenorhabditis elegans


Alignment Length:617 Identity:142/617 - (23%)
Similarity:259/617 - (41%) Gaps:118/617 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 QEPYVHLQHLQQQQQQNPQTVQQLSQITVNRTSKSASVTPTGIRENVMLPSADPEKEAQILYEKS 115
            |:| ||||.:..:.:...:.......|....|..:.:.|.....:.|.:.:.|.:: |..|.:|:
 Worm    61 QDP-VHLQSIALRGRGKSENGSLPDLIEKRETPPTTANTGVSATKRVSVIATDRDR-AYFLRQKN 123

  Fly   116 LQEYHGSQLSTASTATDVIAGKRTLHSICERWLQKHCHCTGSLEVLRLSCRGIGILAV--PVNLP 178
            ::...|                   |:  |:.|.|..|.....:..||....|.|.::  |:...
 Worm   124 MRNNKG-------------------HA--EKDLLKEFHKCKEAQDQRLDLSSIEITSIPSPIKEL 167

  Fly   179 NEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLP 243
            .::..|.|..|.||.| ........||::|.||:|::.:: |::...|..|:.|.|::..|..:|
 Worm   168 TQLTELFLYKNKLTCL-PTEIGQLVNLKKLGLSENALTSL-PDSLASLESLETLDLRHNKLTEVP 230

  Fly   244 PQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGS 308
            ...:: :..|.:|.|..|.:|::| :.:|:|.||:.|.:..|....:|:            .:| 
 Worm   231 SVIYK-IGSLETLWLRYNRIVAVD-EQIGNLSKLKMLDVRENKIRELPS------------AIG- 280

  Fly   309 NLLTIINDEDFPRMPNLIVLLLKRNQIMKI--SAGALKNLTALKVLELDDNLISSLPEGLSKLSQ 371
                        ::.:|:|.|:..|.:.::  ..|...:||.   |:|..|.:|.||..:.||..
 Worm   281 ------------KLTSLVVCLVSYNHLTRVPEEIGDCHSLTQ---LDLQHNDLSELPYSIGKLVN 330

  Fly   372 LQELSITSNRLRWI-NDTELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPE- 434
            |..:.|..|::|.| ::.|..:.::...:.:|.|..:.|.....:.|:..:.||. ..|.:||. 
 Worm   331 LVRIGIRYNKIRCIPSELESCQQLEEFIVESNHLQLLPPNLLTMLPKIHTVNLSR-NELTAFPAG 394

  Fly   435 -LEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIP-NLSSCRDLRLLDLSSNQI 497
             .:...:...:.::...|.::|..:..:..||..|.||.|.|..:| ::.|...:..|:||:||:
 Worm   395 GPQQFVSTVTINMEHNQISKIPIGIFSKATRLTKLNLKENELVSLPLDMGSWTSITELNLSTNQL 459

  Fly   498 EKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKE----------- 551
             |:..:....|..|..|:||.|::|.|| :....:.||:.||||.||:..:..|           
 Worm   460 -KVLPEDIEKLVNLEILVLSNNQLKKLP-NQIGNLNKLRELDLEENELETVPTEIGFLQHLTKLW 522

  Fly   552 -----------AFSGFTALEDLNLGNNIFPELPE-----SGLRAL-------------------- 580
                       :.....:|:||.||.|....:||     ..|::|                    
 Worm   523 VQSNKILTLPRSIGNLCSLQDLRLGENNLTAIPEEIGHLDSLKSLYLNDNSSLHNLPFELALCQS 587

  Fly   581 LHLKTFNNPKLREFPPPDTF--PRIQTLILSY 610
            |.:.:..|..|.:.||..|.  |   :|::.|
 Worm   588 LEIMSIENSPLSQIPPEITAGGP---SLVIQY 616

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380 5/22 (23%)
LRR_RI 180..>383 CDD:238064 51/204 (25%)
leucine-rich repeat 183..204 CDD:275380 6/20 (30%)
LRR_8 203..263 CDD:290566 17/59 (29%)
leucine-rich repeat 205..228 CDD:275380 7/22 (32%)
leucine-rich repeat 229..252 CDD:275380 5/22 (23%)
LRR_8 252..311 CDD:290566 14/58 (24%)
leucine-rich repeat 253..276 CDD:275380 8/22 (36%)
leucine-rich repeat 277..300 CDD:275380 4/22 (18%)
LRR_8 299..359 CDD:290566 11/61 (18%)
leucine-rich repeat 301..324 CDD:275380 1/22 (5%)
leucine-rich repeat 325..348 CDD:275380 6/24 (25%)
LRR_RI 327..567 CDD:238064 69/267 (26%)
leucine-rich repeat 349..371 CDD:275380 8/21 (38%)
LRR_8 370..425 CDD:290566 11/55 (20%)
leucine-rich repeat 372..393 CDD:275380 6/21 (29%)
leucine-rich repeat 394..415 CDD:275380 3/20 (15%)
leucine-rich repeat 418..486 CDD:275380 16/70 (23%)
leucine-rich repeat 441..464 CDD:275378 2/22 (9%)
LRR_8 487..545 CDD:290566 22/57 (39%)
leucine-rich repeat 487..510 CDD:275380 7/22 (32%)
leucine-rich repeat 511..534 CDD:275380 8/22 (36%)
LRR_8 533..589 CDD:290566 20/102 (20%)
leucine-rich repeat 535..558 CDD:275380 8/44 (18%)
leucine-rich repeat 559..580 CDD:275380 9/25 (36%)
7tm_4 764..>892 CDD:304433
7tm_1 770..1017 CDD:278431
soc-2NP_001293758.1 leucine-rich repeat 148..169 CDD:275380 5/20 (25%)
leucine-rich repeat 170..192 CDD:275380 6/22 (27%)
LRR_RI <192..274 CDD:238064 25/84 (30%)
LRR_8 192..249 CDD:290566 17/58 (29%)
leucine-rich repeat 193..215 CDD:275380 7/22 (32%)
leucine-rich repeat 216..238 CDD:275380 5/22 (23%)
LRR_8 238..318 CDD:290566 24/108 (22%)
leucine-rich repeat 239..261 CDD:275380 8/22 (36%)
leucine-rich repeat 262..284 CDD:275380 5/46 (11%)
leucine-rich repeat 285..307 CDD:275380 5/21 (24%)
leucine-rich repeat 308..330 CDD:275380 10/24 (42%)
LRR_RI 327..553 CDD:238064 58/228 (25%)
leucine-rich repeat 331..353 CDD:275380 6/21 (29%)
leucine-rich repeat 354..375 CDD:275380 3/20 (15%)
leucine-rich repeat 402..425 CDD:275380 2/22 (9%)
leucine-rich repeat 449..471 CDD:275380 7/22 (32%)
leucine-rich repeat 472..517 CDD:275380 17/45 (38%)
LRR_8 517..572 CDD:290566 10/54 (19%)
leucine-rich repeat 541..563 CDD:275380 8/21 (38%)
leucine-rich repeat 588..611 CDD:275380 7/25 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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