DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and iglr-2

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_498834.1	Gene:	iglr-2 / 176175	WormBaseID:	WBGene00022580	Length:	773	Species:	Caenorhabditis elegans

Alignment Length:	551	Identity:	103/551 - (18%)
Similarity:	190/551 - (34%)	Gaps:	197/551 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 LQELSITSNRLRWIN-----DTELPRSMQMLDMRANPLSTISPGAF----RGMSKLRKLILSDVR 427
            :|..:.||.|.|..:     |.:|.:..|:|..|....||.:...|    ..:.:::|:..|:::
Worm    13 IQIHTTTSQRNRSSSPSGFLDLQLEKCPQVLGCRCVRDSTRNIQCFSIDESKLLEIQKIYGSNIQ 77

  Fly   428 TLR---------------SFPELE---------------ACH-ALEILKLDRAGIQEVPANLCRQ 461
            .|.               .||:||               ..| .|::|.::.:.:.. .:.:||.
Worm    78 RLELHNWQHDQLNFDIFAPFPQLEHIILRDGDLESLNGTVIHPTLKVLSIENSELTS-SSEVCRL 141

  Fly   462 T---PRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLN----------- 512
            .   |:::||.|..|..::....:|...|::||||.|:|..::..  |.|:.||
Worm   142 LSIFPKIQSLSLSKNYFEKFECDTSNTKLKILDLSQNRISHLEVP--NTLRVLNVSRNRLTSFEN 204

  Fly   513 ------DLLLSYNRIKALP--------------------QDAFQ-GIPKLQLLDLEGNEISYIHK 550
                  ||.:|:|::...|                    |..|| ..|.|..|:::|..:.|
Worm   205 ISTKLTDLDISFNKLSLWPSFDDWKFPNLRSLSAIKLDLQTGFQLDAPLLNSLNIDGASLRY--- 266

  Fly   551 EAFSGFTALEDLNLGNNIFPELPESGLRALLHLK-------------TFNNPKLREFP----PPD 598
                       ||....:.|:|.:...|.|..|:             .|.:..||..|    |..
Worm   267 -----------LNFHQILTPKLKKFSARYLTELRNIAGRLPSTVTDVAFTDTMLRTLPADFIPMS 320

  Fly   599 TFPRIQTLILSYAYH---C--CAF---LPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSM-- 653
            :...:|.:...::.:   |  |..   ||:.|.:|.:|...:....:..:..:..:...:..:
Worm   321 STNHMQKVSFDFSTNQLLCDKCLLQWSLPVYAQTSIRKDCNLTREEIESASCKIGVVANDTGIQY 385

  Fly   654 --------------------MNIWPQMHNLSKQLGASMHDPWETAINFN------EEQLQTQTGG 692
                                ::.|  ....:::||:  :||....|::.      :|..:.|:||
Worm   386 GKYEKPTAISCFSYGVPSPKISWW--RFRPAEKLGS--YDPITDEISYTNVSETMKESYEIQSGG 446

  Fly   693 QIA-----TSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQPGSVQCLPMPGPFLPCADLFD 752
            .:.     .|::|.|     |......||...|::      .|:                .|..|
Worm   447 SLLIRSPNRSHVERY-----VCVVENEYGKDYGIY------HFR----------------LDYLD 484

  Fly   753 WWT---LRCGVW-------VVFLLSLLGNGT 773
            |::   .....|       :|.|:|.|.|.|
Worm   485 WYSYDVFNSVFWGGLATSLIVCLISFLLNIT 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	4/10 (40%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064	57/275 (21%)
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566	14/61 (23%)
		leucine-rich repeat	372..393	CDD:275380	7/25 (28%)
		leucine-rich repeat	394..415	CDD:275380	6/24 (25%)
		leucine-rich repeat	418..486	CDD:275380	18/101 (18%)
		leucine-rich repeat	441..464	CDD:275378	4/25 (16%)
		LRR_8	487..545	CDD:290566	23/95 (24%)
		leucine-rich repeat	487..510	CDD:275380	9/22 (41%)
		leucine-rich repeat	511..534	CDD:275380	10/60 (17%)
		LRR_8	533..589	CDD:290566	13/68 (19%)
		leucine-rich repeat	535..558	CDD:275380	4/22 (18%)
		leucine-rich repeat	559..580	CDD:275380	5/20 (25%)
		7tm_4	764..>892	CDD:304433	5/10 (50%)
		7tm_1	770..1017	CDD:278431	2/4 (50%)
iglr-2	NP_498834.1	leucine-rich repeat	76..99	CDD:275380	2/22 (9%)
		leucine-rich repeat	100..121	CDD:275380	3/20 (15%)
		LRR_RI	<120..>223	CDD:238064	25/105 (24%)
		leucine-rich repeat	122..147	CDD:275380	4/25 (16%)
		leucine-rich repeat	148..169	CDD:275380	5/20 (25%)
		LRR_8	168..219	CDD:290566	15/52 (29%)
		LRR_4	168..206	CDD:289563	11/39 (28%)
		Ig	394..472	CDD:143165	16/86 (19%)
		Apolipoprotein	550..687	CDD:279749
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910