DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and pan-1

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_497925.1	Gene:	pan-1 / 175596	WormBaseID:	WBGene00003915	Length:	594	Species:	Caenorhabditis elegans

Alignment Length:	504	Identity:	117/504 - (23%)
Similarity:	204/504 - (40%)	Gaps:	136/504 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 QLSQITVNRTSKSASVTPTGIRENVMLPSADPEK-EAQILYEKSLQEYHGSQLSTASTATDVIAG 136
            :|.::|:.  ..:.:|.|..:.|||.......|: ....|...|.|.               :.|
Worm    80 ELGRLTIR--DSTVNVLPQDLFENVFAKQVKLERCGLSTLQPNSFQS---------------LGG 127

  Fly   137 KRTLHSICERWLQKHCHCTGSLEVLRLSCRGI--GILAVPVNLPNEVVVLDLGNNNLTKLEANSF 199
            ...|.|:.|..::|       ||      :|:  |:        ..:..|||..|.:.:::..:|
Worm   128 SAELLSLRENRIKK-------LE------KGLFTGL--------KSLKTLDLAMNKIQEIDVGAF 171

  Fly   200 FMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALV 264
            .....:|||.|::|.|..:....|.|:..||:|:||||.|:.:...:|:||..|..|.|:.|.|.
Worm   172 EELKKVEELLLNENDIRVLKTGTFDGMKNLKKLTLQNCNLEIIQKGAFRGLNSLEQLILSNNNLE 236

  Fly   265 SLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLL 329
            ::|                        ....:.|:.|..|:||||.::.:..:.||::..|:
Worm   237 NID------------------------WTIFSALKNLRVLDLGSNKISNVEMKSFPKLEKLV--- 274

  Fly   330 LKRNQIMKISAGALKNLTALKVLELDDNLISSLPE----GLSKLSQLQELSITSNRLRWINDTEL 390
            |..|.|..:.:..||:|.:|.|...|.|.|.|:.:    ||::..:::.||:..|.
Worm   275 LNNNTIDSMKSIKLKDLPSLVVALFDRNKIESIGDMDMFGLTRSDRIETLSLARNN--------- 330

  Fly   391 PRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVP 455
                         ||.|||.||:....|..|:|
Worm   331 -------------LSQISPKAFQHTPNLITLLL-------------------------------- 350

  Fly   456 ANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNR 520
                 |..:::.|...:.|..|.|.|:|.:.|..|.||||.:..|:.....  |.|:.|.|.:|.
Worm   351 -----QYNQIEELSSHSPSQVRTPFLASLKKLVTLQLSSNNLSVIRSDELP--KSLSSLALDHNV 408

  Fly   521 IKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFT--ALEDLNLGNN 567
            |..:...|.:|: :::.|.|..|:::|:::..|..|:  ::|.:::..|
Worm   409 ISKIEARALEGM-EIKRLYLHSNKLNYLYQGTFDSFSPKSVEAVDVSLN 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	4/22 (18%)
		LRR_RI	180..>383	CDD:238064	57/206 (28%)
		leucine-rich repeat	183..204	CDD:275380	5/20 (25%)
		LRR_8	203..263	CDD:290566	23/59 (39%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		leucine-rich repeat	229..252	CDD:275380	11/22 (50%)
		LRR_8	252..311	CDD:290566	13/58 (22%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	1/22 (5%)
		LRR_8	299..359	CDD:290566	19/59 (32%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		LRR_RI	327..567	CDD:238064	56/245 (23%)
		leucine-rich repeat	349..371	CDD:275380	8/25 (32%)
		LRR_8	370..425	CDD:290566	13/54 (24%)
		leucine-rich repeat	372..393	CDD:275380	3/20 (15%)
		leucine-rich repeat	394..415	CDD:275380	7/20 (35%)
		leucine-rich repeat	418..486	CDD:275380	10/67 (15%)
		leucine-rich repeat	441..464	CDD:275378	1/22 (5%)
		LRR_8	487..545	CDD:290566	18/57 (32%)
		leucine-rich repeat	487..510	CDD:275380	7/22 (32%)
		leucine-rich repeat	511..534	CDD:275380	7/22 (32%)
		LRR_8	533..589	CDD:290566	8/37 (22%)
		leucine-rich repeat	535..558	CDD:275380	6/24 (25%)
		leucine-rich repeat	559..580	CDD:275380	2/9 (22%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
pan-1	NP_497925.1	leucine-rich repeat	130..152	CDD:275380	8/42 (19%)
		LRR_8	132..187	CDD:290566	17/75 (23%)
		leucine-rich repeat	153..176	CDD:275380	5/22 (23%)
		leucine-rich repeat	177..200	CDD:275380	8/22 (36%)
		LRR_8	199..259	CDD:290566	24/83 (29%)
		leucine-rich repeat	201..224	CDD:275380	11/22 (50%)
		LRR_RI	224..434	CDD:238064	68/298 (23%)
		leucine-rich repeat	225..248	CDD:275380	7/46 (15%)
		leucine-rich repeat	249..269	CDD:275380	7/19 (37%)
		LRR_8	268..355	CDD:290566	30/148 (20%)
		leucine-rich repeat	270..293	CDD:275380	7/25 (28%)
		leucine-rich repeat	294..320	CDD:275380	8/25 (32%)
		LRR_8	320..387	CDD:290566	26/125 (21%)
		leucine-rich repeat	321..344	CDD:275380	10/44 (23%)
		LRR_8	375..432	CDD:290566	18/59 (31%)
		leucine-rich repeat	377..398	CDD:275380	7/22 (32%)
		leucine-rich repeat	399..420	CDD:275380	6/20 (30%)
		leucine-rich repeat	423..442	CDD:275380	5/18 (28%)
		LRR_RI	80..326	CDD:238064	75/310 (24%)
		leucine-rich repeat	81..104	CDD:275380	7/24 (29%)
		leucine-rich repeat	105..128	CDD:275380	4/37 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910