DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and lron-15

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_495322.3	Gene:	lron-15 / 174079	WormBaseID:	WBGene00016974	Length:	1275	Species:	Caenorhabditis elegans

Alignment Length:	591	Identity:	152/591 - (25%)
Similarity:	240/591 - (40%)	Gaps:	120/591 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 SICERWLQKHCHCTGSLEVLRLSCRGIGIL------AVPVN--------------LPN------E 180
            |:...|...:.|   ||::|.|....|.:|      ...:|              :||      .
Worm   156 SVIPTWALTYLH---SLQILHLENNRIDVLRSNTFDETQLNNLQFLYLDNNQLRIIPNLAFNHLR 217

  Fly   181 VVVLDLGNNNLTK--------------------------------------LEANSFFMAPNLEE 207
            :|||.|.||.:|:                                      ||.|:.....:..|
Worm   218 LVVLMLANNRITEIQKMSLPQTLKFLVLRNNLLTQIPYVALNDLKTLQSIDLEGNNITHLMDTNE 282

  Fly   208 LT--------LSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALV 264
            :|        |.:|.:..:|.::|....|::.|.:....::::...||:.:..:.||.|:.|.:.
Worm   283 VTFESEMKVILRNNKVRRLDKHSFRSFRKIRELDISYNQIQTVEDSSFETVGHMQSLDLSYNRIA 347

  Fly   265 SLDGDCLGHLQK-LRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPR--MPNLI 326
            .|....|.:..| |:||:|..|:.:..| .||..||.|..|||..|.|..| |.|..:  ...|:
Worm   348 YLPRGMLKNFAKTLKTLKLAENMIHATP-EALRDLRNLTHLNLNGNKLNRI-DGDVLKGCTDTLV 410

  Fly   327 VLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQE-------LSITSNRLRW 384
            .|.:..|.:..|..|.|..:..|:.|::..|.|.||.:..|.||..:|       |::..||:..
Worm   411 ELFIANNYLEHIPHGVLSGMKQLEHLDISKNKIMSLKKPTSLLSITKEETSTVRRLNLAGNRINN 475

  Fly   385 INDTELPRSMQML---DMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKL 446
            ::|..:...|.:|   |:..|.:..|||..|..:..|..|.|.: ..|..||.|.....|..|.|
Worm   476 MSDYLIFEHMPLLTYVDVSFNRIRFISPRVFEKLKNLESLFLQN-NQLAHFPSLFRLDKLRHLML 539

  Fly   447 DRAGIQEVPANLCRQTPRLKSLELKTNSLKRI-PNL---SSCRDLRLLDLSSNQIEKIQGKPFNG 507
            |...||::........|:|:.|.|..|.|..| .|:   ||..:|:.|:|:.|:|..|..:.|:.
Worm   540 DNNQIQKIDNFSLADLPKLQHLSLAGNQLDIITENMFGSSSSSELKSLNLAHNKIHSISSRSFSD 604

  Fly   508 LKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPEL 572
            |..|..|.||:|.|:.:....|..:..|:.|||..|.|..|...|.....||:.|:|.:|...|:
Worm   605 LDNLQQLRLSHNNIRTITSMTFSNLRNLRYLDLSHNRIIKILPSALYQLPALDVLHLDHNNLNEI 669

  Fly   573 PESGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSY-AYH--CCAFLPLVAMSSQ--KKTSQV 632
            .....|                    :|..:|:|.||: |:.  .|.||..::...|  ..::|:
Worm   670 DRDAFR--------------------SFSDLQSLKLSHNAFRRFSCEFLGSISQVHQLDLSSNQI 714

  Fly   633 QEAVLF 638
            .|..:|
Worm   715 NEIDIF 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	6/40 (15%)
		LRR_RI	180..>383	CDD:238064	65/258 (25%)
		leucine-rich repeat	183..204	CDD:275380	9/58 (16%)
		LRR_8	203..263	CDD:290566	14/67 (21%)
		leucine-rich repeat	205..228	CDD:275380	6/30 (20%)
		leucine-rich repeat	229..252	CDD:275380	3/22 (14%)
		LRR_8	252..311	CDD:290566	22/59 (37%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	9/22 (41%)
		LRR_8	299..359	CDD:290566	19/61 (31%)
		leucine-rich repeat	301..324	CDD:275380	9/24 (38%)
		leucine-rich repeat	325..348	CDD:275380	6/22 (27%)
		LRR_RI	327..567	CDD:238064	77/253 (30%)
		leucine-rich repeat	349..371	CDD:275380	8/21 (38%)
		LRR_8	370..425	CDD:290566	17/64 (27%)
		leucine-rich repeat	372..393	CDD:275380	5/27 (19%)
		leucine-rich repeat	394..415	CDD:275380	8/23 (35%)
		leucine-rich repeat	418..486	CDD:275380	23/71 (32%)
		leucine-rich repeat	441..464	CDD:275378	6/22 (27%)
		LRR_8	487..545	CDD:290566	20/57 (35%)
		leucine-rich repeat	487..510	CDD:275380	8/22 (36%)
		leucine-rich repeat	511..534	CDD:275380	7/22 (32%)
		LRR_8	533..589	CDD:290566	15/55 (27%)
		leucine-rich repeat	535..558	CDD:275380	8/22 (36%)
		leucine-rich repeat	559..580	CDD:275380	6/20 (30%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
lron-15	NP_495322.3	LRR_8	95..155	CDD:290566
		leucine-rich repeat	120..144	CDD:275380
		LRR_RI	<144..348	CDD:238064	36/194 (19%)
		LRR_8	144..205	CDD:290566	10/51 (20%)
		leucine-rich repeat	145..168	CDD:275380	3/14 (21%)
		leucine-rich repeat	169..194	CDD:275380	5/24 (21%)
		leucine-rich repeat	195..217	CDD:275380	2/21 (10%)
		LRR_8	217..274	CDD:290566	10/56 (18%)
		leucine-rich repeat	218..239	CDD:275380	7/20 (35%)
		leucine-rich repeat	240..263	CDD:275380	0/22 (0%)
		leucine-rich repeat	264..311	CDD:275380	9/46 (20%)
		LRR_8	289..346	CDD:290566	12/56 (21%)
		leucine-rich repeat	312..335	CDD:275380	3/22 (14%)
		leucine-rich repeat	336..356	CDD:275380	6/19 (32%)
		LRR_RI	<338..498	CDD:238064	50/161 (31%)
		leucine-rich repeat	361..383	CDD:275380	9/22 (41%)
		leucine-rich repeat	384..405	CDD:275380	9/21 (43%)
		LRR_8	408..473	CDD:290566	18/64 (28%)
		leucine-rich repeat	409..432	CDD:275380	6/22 (27%)
		leucine-rich repeat	433..462	CDD:275380	10/28 (36%)
		LRR_8	461..522	CDD:290566	15/61 (25%)
		leucine-rich repeat	463..487	CDD:275380	5/23 (22%)
		leucine-rich repeat	488..511	CDD:275380	7/22 (32%)
		LRR_8	510..568	CDD:290566	18/58 (31%)
		LRR_4	510..551	CDD:289563	13/41 (32%)
		leucine-rich repeat	512..533	CDD:275380	7/21 (33%)
		LRR_4	533..573	CDD:289563	13/39 (33%)
		leucine-rich repeat	534..557	CDD:275380	6/22 (27%)
		leucine-rich repeat	558..581	CDD:275380	8/22 (36%)
		LRR_8	583..642	CDD:290566	20/58 (34%)
		leucine-rich repeat	584..607	CDD:275380	8/22 (36%)
		LRR_RI	<607..799	CDD:238064	35/134 (26%)
		leucine-rich repeat	608..631	CDD:275380	7/22 (32%)
		LRR_8	630..688	CDD:290566	20/77 (26%)
		leucine-rich repeat	632..655	CDD:275380	8/22 (36%)
		leucine-rich repeat	656..676	CDD:275380	6/39 (15%)
		leucine-rich repeat	680..703	CDD:275380	8/22 (36%)
		leucine-rich repeat	704..749	CDD:275380	4/17 (24%)
		leucine-rich repeat	726..739	CDD:275378
		LRR_8	748..808	CDD:290566
		leucine-rich repeat	750..771	CDD:275380
		leucine-rich repeat	774..797	CDD:275380
		LRR_8	797..856	CDD:290566
		LRR_RI	<798..982	CDD:238064
		leucine-rich repeat	798..845	CDD:275380
		LRR_8	845..904	CDD:290566
		leucine-rich repeat	846..869	CDD:275380
		leucine-rich repeat	870..893	CDD:275380
		leucine-rich repeat	894..915	CDD:275380
		LRR_8	938..998	CDD:290566
		leucine-rich repeat	940..963	CDD:275380
		leucine-rich repeat	964..987	CDD:275380
		leucine-rich repeat	988..1009	CDD:275380
		leucine-rich repeat	1038..1064	CDD:275380
		leucine-rich repeat	1113..1139	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910