DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and egg-6

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_492348.1	Gene:	egg-6 / 172670	WormBaseID:	WBGene00010621	Length:	961	Species:	Caenorhabditis elegans

Alignment Length:	492	Identity:	115/492 - (23%)
Similarity:	206/492 - (41%)	Gaps:	86/492 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 TASTATDVIAGKRTLHSICERWLQKHCHCTGSLEVLRLSCRG----------------------- 167
            |......:||...:....|.| :.:.|.|..|..::.|||.|
Worm     5 TLIAVAHLIAFLSSAEITCPR-IPEKCDCKISKSMIILSCNGEDVKTIAQTVGTSQIDELHILNG 68

  Fly   168 --IGILAVPVNLPNEVVVLDLGNNNLTKLEANSF-FMAPNLEELTLSDNSIINMDPNAFYGLAKL 229
              :.|.::|.|....:.:|   |:.|......:: .:...:|.:|::.|.:..:.  .|..|:.|
Worm    69 TDVKIESLPFNGLRTIAIL---NSTLQSFSPTAWRHVEATIEHITINGNELKTVP--VFGNLSTL 128

  Fly   230 KRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQ-KLRTLRLEGNLFYRIPTN 293
            ..::|.:..:.|:|.::|.||:.||.|:|..||:.......|..:: .|..|.:.||....||..
Worm   129 MSMNLNSNQISSIPDKAFNGLSALTQLRLENNAICDFPPKSLDAVKASLVLLDVSGNCLDAIPAQ 193

  Fly   294 ALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNL 358
            .|.....|..|:||||.::.||:.:...:|.|..|.::.|.:.:|...|..|:..|:.|.|.||:
Worm   194 ILRNAANLMYLDLGSNNISEINNFELMNLPFLRELRVQNNTLRRIHPMAFMNVPQLQYLYLQDNI 258

  Fly   359 ISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLIL 423
            ||:|               ..|||:..      :::::||:..|.|..:.
Worm   259 ISTL---------------DGNRLQGF------KNLEVLDVSNNALYALP--------------- 287

  Fly   424 SDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIP--NLSSCRD 486
                :|:..|.|:.      :::|...|.::........|.|:.:.::.|::.:|.  :..|...
Worm   288 ----SLKDLPNLKQ------VRVDGNLITKIETLAFSNNPNLQLISVQNNNIVQISRNSFESLDK 342

  Fly   487 LRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKE 551
            |.:|.:.:|.:.||:...|:|:|.|..|.:..|.:.||...:|..:..|..|||..|:|..|.:.
Worm   343 LVVLLVGNNSLAKIERGMFDGMKNLQQLSIRNNTLTALDASSFAQLAHLTTLDLGHNKIHDIEEG 407

  Fly   552 AFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNN 588
            .|...:.|..|:|.||..     ||.:..:..|..:|
Worm   408 TFDKLSKLFWLDLSNNKI-----SGFKTSVFKKKISN 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	7/45 (16%)
		LRR_RI	180..>383	CDD:238064	54/204 (26%)
		leucine-rich repeat	183..204	CDD:275380	3/21 (14%)
		LRR_8	203..263	CDD:290566	17/59 (29%)
		leucine-rich repeat	205..228	CDD:275380	5/22 (23%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..311	CDD:290566	20/59 (34%)
		leucine-rich repeat	253..276	CDD:275380	7/23 (30%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		LRR_8	299..359	CDD:290566	20/59 (34%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..348	CDD:275380	6/22 (27%)
		LRR_RI	327..567	CDD:238064	55/241 (23%)
		leucine-rich repeat	349..371	CDD:275380	8/21 (38%)
		LRR_8	370..425	CDD:290566	7/54 (13%)
		leucine-rich repeat	372..393	CDD:275380	3/20 (15%)
		leucine-rich repeat	394..415	CDD:275380	4/20 (20%)
		leucine-rich repeat	418..486	CDD:275380	10/69 (14%)
		leucine-rich repeat	441..464	CDD:275378	2/22 (9%)
		LRR_8	487..545	CDD:290566	19/57 (33%)
		leucine-rich repeat	487..510	CDD:275380	7/22 (32%)
		leucine-rich repeat	511..534	CDD:275380	6/22 (27%)
		LRR_8	533..589	CDD:290566	17/56 (30%)
		leucine-rich repeat	535..558	CDD:275380	8/22 (36%)
		leucine-rich repeat	559..580	CDD:275380	7/20 (35%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
egg-6	NP_492348.1	LRR_8	107..162	CDD:290566	17/56 (30%)
		leucine-rich repeat	107..127	CDD:275380	5/21 (24%)
		leucine-rich repeat	128..151	CDD:275380	7/22 (32%)
		LRR_RI	<144..281	CDD:238064	45/157 (29%)
		leucine-rich repeat	152..200	CDD:275380	14/47 (30%)
		LRR_8	176..233	CDD:290566	18/56 (32%)
		leucine-rich repeat	201..224	CDD:275380	8/22 (36%)
		LRR_8	225..283	CDD:290566	20/78 (26%)
		leucine-rich repeat	225..248	CDD:275380	6/22 (27%)
		LRR_RI	<240..458	CDD:238064	58/251 (23%)
		leucine-rich repeat	249..272	CDD:275380	11/43 (26%)
		LRR_8	271..329	CDD:290566	12/82 (15%)
		leucine-rich repeat	273..294	CDD:275380	5/39 (13%)
		leucine-rich repeat	295..318	CDD:275380	3/28 (11%)
		LRR_8	317..375	CDD:290566	15/57 (26%)
		leucine-rich repeat	319..342	CDD:275380	4/22 (18%)
		leucine-rich repeat	343..366	CDD:275380	7/22 (32%)
		LRR_8	365..425	CDD:290566	20/59 (34%)
		leucine-rich repeat	367..390	CDD:275380	6/22 (27%)
		leucine-rich repeat	391..414	CDD:275380	8/22 (36%)
		leucine-rich repeat	415..434	CDD:275380	7/23 (30%)
		leucine-rich repeat	437..449	CDD:275378	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910