DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and lron-9

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001076615.1	Gene:	lron-9 / 172529	WormBaseID:	WBGene00011971	Length:	653	Species:	Caenorhabditis elegans

Alignment Length:	589	Identity:	131/589 - (22%)
Similarity:	224/589 - (38%)	Gaps:	148/589 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PLLLQLLLQLLLLPPSAMGHDETKENPAPDMQNSQEQEPYVHLQHLQQQQQQNPQTVQQLSQITV 79
            ||:...|:||..:...|...:      .||:...:.|                    ..|||..:
Worm     3 PLVAIFLVQLCFVAVGAAIPN------CPDLDVLENQ--------------------SDLSQDDL 41

  Fly    80 NRTSKSASVTPTGIRENVMLPSADPEKEAQILYEKSLQEYHGSQLSTASTATDVIAGKRTLHSIC 144
            |               |::|....|:.:.:::    :...:||.|.....||:.:.....:
Worm    42 N---------------NLILCFCKPDDKEKVV----ISCLYGSNLDHLMKATEAVKNASLI---- 83

  Fly   145 ERWLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELT 209
                      |.|:.:..:.....|       ||      :.|.            :||:|:.|.
Worm    84 ----------TSSISIQHMEFPDGG-------LP------EFGK------------LAPDLKSLE 113

  Fly   210 L---SDNSIINMDPNAFYGLAK-LKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDC 270
            :   |....:.:..::|.||.: |:.|::..|.|:::|| |...|..|.::..:.|.|.||..|.
Worm   114 IKECSGQDELKVGDDSFKGLEQTLRNLTIHACNLQTIPP-SVDSLENLETVVFSNNKLDSLGVDQ 177

  Fly   271 LGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIIND---EDFPRMPNLIVLLLKR 332
            ..:.::|..|.:.||....|...|...|.:||.|.:|.:  ..||:   |:..|:..|..|.|.|
Worm   178 FKNKKQLSYLDVSGNFITSIEEKAFEPLTSLETLVIGEH--NFINETVVEEIGRLKALKTLDLSR 240

  Fly   333 -NQIMKISAGALKNLTALKVLELDDNLISSLPEG-LSKLSQLQELSITSNRLRWINDTELPRSMQ 395
             :.|.:......|.:..::||:|....|.:|..| .:.|.:|:|
Worm   241 ADGIFQPPETLFKEIPQIEVLKLSGCSIPTLEPGQFATLKKLKE--------------------- 284

  Fly   396 MLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPEL-EACHALEILKLDRAGIQEVPANLC 459
             ||:|.|.:..|:..||.|:..|.:|.|:.....:..|:: ....:||.|.|....|:.:|.::.
Worm   285 -LDLRVNLIENITAYAFDGLESLTRLSLAGNFISKLEPDVFFGLSSLEELDLGWNEIKTIPTDVF 348

  Fly   460 RQ-TPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKA 523
            :. |.:||::.|:.|.:..:|:                         .||..|..|.|:.....:
Worm   349 KPLTDKLKTISLRNNPISELPS-------------------------TGLGMLEKLSLAECGFTS 388

  Fly   524 LPQDAFQGIPKLQLLDLEGNEISYIHKEAFSG-FTALEDLNLGNNIFPELPE--SGLRALLHLKT 585
            :..|..:..|||:.|||....||.|.:..|.. ..:|:.|||..|....||.  ..|.|:..|..
Worm   389 ISADQLKDYPKLEELDLSKCNISNIVENTFENQKDSLKKLNLQKNKLKSLPNLIKNLPAIESLDV 453

  Fly   586 FNNP 589
            .:||
Worm   454 SSNP 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	2/20 (10%)
		LRR_RI	180..>383	CDD:238064	53/211 (25%)
		leucine-rich repeat	183..204	CDD:275380	2/20 (10%)
		LRR_8	203..263	CDD:290566	17/63 (27%)
		leucine-rich repeat	205..228	CDD:275380	6/25 (24%)
		leucine-rich repeat	229..252	CDD:275380	8/22 (36%)
		LRR_8	252..311	CDD:290566	17/58 (29%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		LRR_8	299..359	CDD:290566	17/63 (27%)
		leucine-rich repeat	301..324	CDD:275380	8/25 (32%)
		leucine-rich repeat	325..348	CDD:275380	6/23 (26%)
		LRR_RI	327..567	CDD:238064	58/244 (24%)
		leucine-rich repeat	349..371	CDD:275380	7/22 (32%)
		LRR_8	370..425	CDD:290566	13/54 (24%)
		leucine-rich repeat	372..393	CDD:275380	2/20 (10%)
		leucine-rich repeat	394..415	CDD:275380	7/20 (35%)
		leucine-rich repeat	418..486	CDD:275380	16/69 (23%)
		leucine-rich repeat	441..464	CDD:275378	7/23 (30%)
		LRR_8	487..545	CDD:290566	12/57 (21%)
		leucine-rich repeat	487..510	CDD:275380	2/22 (9%)
		leucine-rich repeat	511..534	CDD:275380	4/22 (18%)
		LRR_8	533..589	CDD:290566	20/58 (34%)
		leucine-rich repeat	535..558	CDD:275380	8/23 (35%)
		leucine-rich repeat	559..580	CDD:275380	8/22 (36%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
lron-9	NP_001076615.1	leucine-rich repeat	137..159	CDD:275380	8/22 (36%)
		LRR_8	159..217	CDD:290566	17/59 (29%)
		leucine-rich repeat	160..183	CDD:275380	6/22 (27%)
		leucine-rich repeat	184..207	CDD:275380	7/22 (32%)
		leucine-rich repeat	208..232	CDD:275380	8/25 (32%)
		LRR_8	233..292	CDD:290566	19/80 (24%)
		leucine-rich repeat	233..257	CDD:275380	6/23 (26%)
		LRR_RI	234..456	CDD:238064	64/268 (24%)
		leucine-rich repeat	258..281	CDD:275380	7/22 (32%)
		LRR_8	280..340	CDD:290566	18/81 (22%)
		leucine-rich repeat	282..305	CDD:275380	10/44 (23%)
		leucine-rich repeat	306..329	CDD:275380	4/22 (18%)
		LRR_8	328..410	CDD:290566	24/106 (23%)
		leucine-rich repeat	330..375	CDD:275380	14/69 (20%)
		leucine-rich repeat	376..399	CDD:275380	4/22 (18%)
		LRR_8	398..457	CDD:290566	20/58 (34%)
		leucine-rich repeat	400..420	CDD:275380	8/19 (42%)
		leucine-rich repeat	425..447	CDD:275380	8/21 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910