DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Y54E10A.6

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001380012.1	Gene:	Y54E10A.6 / 171890	WormBaseID:	WBGene00021828	Length:	507	Species:	Caenorhabditis elegans

Alignment Length:	422	Identity:	109/422 - (25%)
Similarity:	175/422 - (41%)	Gaps:	96/422 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 EVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPP 244
            |:|:.::..:::|:        |.||.:            ...|..:::|..|||..|.|.:| .
Worm    18 EIVIKNVRIDSVTE--------AANLSQ------------KRVFESMSQLNLLSLTGCSLHNL-S 61

  Fly   245 QSFQGLAQLTSLQLNGNALVSLDG--DCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLG 307
            .|.:..:.|..|.|..|.|..|..  ||   |.||:.:.|..|....:|. :::....||:|.|.
Worm    62 SSIRSCSNLMHLVLPKNDLKQLPDVFDC---LPKLKFMDLSHNHLDALPA-SISKCENLESLILN 122

  Fly   308 SNLLTIINDEDFP---RMPNLIVLLLKRNQIMKISAGALK-NLTA-LKVLELDDNLISSLPEGLS 367
            :|.|   |:..||   .:.||.:.....|.|.||.|.... ||:| |..:.|..|.|..:|:.||
Worm   123 NNRL---NESSFPDISNLSNLHIFDAAHNTISKIPASLTSHNLSAKLHTIILSHNSIEVIPDSLS 184

  Fly   368 KLSQLQELSITSNRLRWIND--TELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLR 430
            .|.||:||.|..|:|:.:..  ..||: :::||:..|..|.         |:.:|| .:|.|
Worm   185 NLKQLKELKIDENKLKDVPSVIAHLPK-LKVLDISKNCFSE---------SRFQKL-ANDKR--- 235

  Fly   431 SFPELEACHAL------------EILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSS 483
              .:|.|..||            |..|...:|..:.|.   ...|......::..:::|.|::|.
Worm   236 --GKLNAVIALAQKIGKPIGNSEEQKKAPESGSPDFPV---PDAPLTVRTGIENLTVRRHPSVSE 295

  Fly   484 CRDLRLLDLSSNQIEKIQG---KPFNGLK-QLNDLLLSYNR-IKALPQ---DAFQ------GIPK 534
            .|.. |:....|.::...|   |.|..|: :::...|..|| :.|:..   |:||      .:||
Worm   296 IRPY-LVCCVINNVDLNGGDSFKKFIALQTKMHASALCENRTLSAIGTHRLDSFQLPLCYMALPK 359

  Fly   535 LQLLDLEGNEISYIH----KEAFSGFTALEDL 562
            .:|         ||.    |.:.|....|:.|
Worm   360 DEL---------YIRALNKKSSVSASELLDSL 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	62/209 (30%)
		leucine-rich repeat	183..204	CDD:275380	2/20 (10%)
		LRR_8	203..263	CDD:290566	15/59 (25%)
		leucine-rich repeat	205..228	CDD:275380	2/22 (9%)
		leucine-rich repeat	229..252	CDD:275380	8/22 (36%)
		LRR_8	252..311	CDD:290566	19/60 (32%)
		leucine-rich repeat	253..276	CDD:275380	9/24 (38%)
		leucine-rich repeat	277..300	CDD:275380	4/22 (18%)
		LRR_8	299..359	CDD:290566	22/64 (34%)
		leucine-rich repeat	301..324	CDD:275380	9/25 (36%)
		leucine-rich repeat	325..348	CDD:275380	8/23 (35%)
		LRR_RI	327..567	CDD:238064	69/270 (26%)
		leucine-rich repeat	349..371	CDD:275380	8/21 (38%)
		LRR_8	370..425	CDD:290566	16/56 (29%)
		leucine-rich repeat	372..393	CDD:275380	8/22 (36%)
		leucine-rich repeat	394..415	CDD:275380	4/20 (20%)
		leucine-rich repeat	418..486	CDD:275380	16/79 (20%)
		leucine-rich repeat	441..464	CDD:275378	5/34 (15%)
		LRR_8	487..545	CDD:290566	16/71 (23%)
		leucine-rich repeat	487..510	CDD:275380	6/26 (23%)
		leucine-rich repeat	511..534	CDD:275380	7/32 (22%)
		LRR_8	533..589	CDD:290566	9/34 (26%)
		leucine-rich repeat	535..558	CDD:275380	5/26 (19%)
		leucine-rich repeat	559..580	CDD:275380	2/4 (50%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Y54E10A.6	NP_001380012.1	LRR	<45..>219	CDD:227223	60/182 (33%)
		leucine-rich repeat	47..69	CDD:275380	8/22 (36%)
		leucine-rich repeat	70..92	CDD:275380	9/24 (38%)
		leucine-rich repeat	93..115	CDD:275380	4/22 (18%)
		leucine-rich repeat	116..139	CDD:275380	9/25 (36%)
		leucine-rich repeat	140..164	CDD:275380	8/23 (35%)
		leucine-rich repeat	166..188	CDD:275380	8/21 (38%)
		leucine-rich repeat	189..211	CDD:275380	7/21 (33%)
		PLN02265	266..>495	CDD:215149	28/130 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910