DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Cd180

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_032559.2	Gene:	Cd180 / 17079	MGIID:	1194924	Length:	661	Species:	Mus musculus

Alignment Length:	745	Identity:	173/745 - (23%)
Similarity:	288/745 - (38%)	Gaps:	181/745 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 IAGKRTLHSICERWLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNN--------- 189
            :|..|...|..::.::|..:.|       .:|..:|:..:|..|||....|:...|
Mouse    15 LASCRATTSSDQKCIEKEVNKT-------YNCENLGLNEIPGTLPNSTECLEFSFNVLPTIQNTT 72

  Fly   190 -----NLTKLE----------ANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGL 239
                 |||.|:          .::|.....|:.|.|:.|.:|.|...|..|...||.|.....|:
Mouse    73 FSRLINLTFLDLTRCQIYWIHEDTFQSQHRLDTLVLTANPLIFMAETALSGPKALKHLFFIQTGI 137

  Fly   240 KSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEAL 304
            .|:..........|.||.|..|.:.|:........:||:.|..:.|..:.:....::.|:  :|.
Mouse   138 SSIDFIPLHNQKTLESLYLGSNHISSIKLPKGFPTEKLKVLDFQNNAIHYLSKEDMSSLQ--QAT 200

  Fly   305 NLGSNL--------------LTIINDEDFPRMPNLIVLL--LKRNQIMKISAGALKNLTALKVLE 353
            ||..||              ..:....:|....||:|:.  ||.:.|..:..|..:::.
Mouse   201 NLSLNLNGNDIAGIELGAFDSAVFQSLNFGGTQNLLVIFKGLKNSTIQSLWLGTFEDMD------ 259

  Fly   354 LDDNLISSLPEGLSKLS----QLQE---LSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGA 411
             |:::..::.|||.::|    .||:   .:|:||.....:      .:|.||:.|..||.: |..
Mouse   260 -DEDISPAVFEGLCEMSVESINLQKHYFFNISSNTFHCFS------GLQELDLTATHLSEL-PSG 316

  Fly   412 FRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLK 476
            ..|:|.|:||:|| .....:..::.|.:...:..|...|             ..|.|||.|..|:
Mouse   317 LVGLSTLKKLVLS-ANKFENLCQISASNFPSLTHLSIKG-------------NTKRLELGTGCLE 367

  Fly   477 RIPNLSSCRDLRLLDLSSNQIE-----KIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQ 536
            .:.|      ||.||||.:.||     .:|.:..:.|:.||   ||||...:|..:||:..|:|:
Mouse   368 NLEN------LRELDLSHDDIETSDCCNLQLRNLSHLQSLN---LSYNEPLSLKTEAFKECPQLE 423

  Fly   537 LLDLEGNEISYIHKEA---FSGFTALEDLNLGNNIFPELPE---SGLRALLHLKTFNN--PK--L 591
            ||||....:..  |:|   |.....|:.|||.:::.....|   .||.||.||....|  ||  :
Mouse   424 LLDLAFTRLKV--KDAQSPFQNLHLLKVLNLSHSLLDISSEQLFDGLPALQHLNLQGNHFPKGNI 486

  Fly   592 REFPPPDTFPRIQTLILSY---------AYHCCAFLPLVAMSSQKKTSQVQEAV-----LFPSDA 642
            ::.....|..|::.|:||:         |:.....:..|.:|..:.||...||:     ::
Mouse   487 QKTNSLQTLGRLEILVLSFCDLSSIDQHAFTSLKMMNHVDLSHNRLTSSSIEALSHLKGIY---- 547

  Fly   643 EFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHD 707
               :.|.:|.:..|.|.:..:..|         :..||..:..|..    ..:..|..|:::|:
Mouse   548 ---LNLASNRISIILPSLLPILSQ---------QRTINLRQNPLDC----TCSNIYFLEWYKEN- 595

  Fly   708 VSGPATGYGFGTGLFSGMSTEDFQPGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNG 772
                         :.....|||       .|....|.|....|.| .||.|.:..|.:..|
Mouse   596 -------------MQKLEDTED-------TLCENPPLLRGVRLSD-VTLSCSMAAVGIFFL---- 635

  Fly   773 TVVFVLLCSRSKMDVPRFLVCNLAAADFFM 802
             :||:|:          |.:..:.|..:|:
Mouse   636 -IVFLLV----------FAILLIFAVKYFL 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	4/20 (20%)
		LRR_RI	180..>383	CDD:238064	54/249 (22%)
		leucine-rich repeat	183..204	CDD:275380	7/44 (16%)
		LRR_8	203..263	CDD:290566	18/59 (31%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		leucine-rich repeat	229..252	CDD:275380	5/22 (23%)
		LRR_8	252..311	CDD:290566	16/72 (22%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	4/22 (18%)
		LRR_8	299..359	CDD:290566	14/75 (19%)
		leucine-rich repeat	301..324	CDD:275380	6/36 (17%)
		leucine-rich repeat	325..348	CDD:275380	6/24 (25%)
		LRR_RI	327..567	CDD:238064	71/256 (28%)
		leucine-rich repeat	349..371	CDD:275380	5/25 (20%)
		LRR_8	370..425	CDD:290566	19/61 (31%)
		leucine-rich repeat	372..393	CDD:275380	5/23 (22%)
		leucine-rich repeat	394..415	CDD:275380	7/20 (35%)
		leucine-rich repeat	418..486	CDD:275380	15/67 (22%)
		leucine-rich repeat	441..464	CDD:275378	2/22 (9%)
		LRR_8	487..545	CDD:290566	25/62 (40%)
		leucine-rich repeat	487..510	CDD:275380	10/27 (37%)
		leucine-rich repeat	511..534	CDD:275380	9/22 (41%)
		LRR_8	533..589	CDD:290566	21/63 (33%)
		leucine-rich repeat	535..558	CDD:275380	8/25 (32%)
		leucine-rich repeat	559..580	CDD:275380	7/23 (30%)
		7tm_4	764..>892	CDD:304433	7/39 (18%)
		7tm_1	770..1017	CDD:278431	6/33 (18%)
Cd180	NP_032559.2	leucine-rich repeat	38..57	CDD:275380	6/18 (33%)
		LRR 1	54..75		2/20 (10%)
		leucine-rich repeat	58..78	CDD:275380	2/19 (11%)
		LRR 2	78..99		5/20 (25%)
		leucine-rich repeat	79..102	CDD:275380	4/22 (18%)
		LRR 3	102..123		7/20 (35%)
		leucine-rich repeat	103..126	CDD:275380	8/22 (36%)
		LRR 4	126..147		5/20 (25%)
		leucine-rich repeat	127..150	CDD:275380	5/22 (23%)
		LRR 5	150..171		6/20 (30%)
		leucine-rich repeat	151..174	CDD:275380	6/22 (27%)
		LRR 6	174..195		4/20 (20%)
		leucine-rich repeat	175..201	CDD:275380	5/27 (19%)
		LRR 7	201..221		4/19 (21%)
		leucine-rich repeat	224..275	CDD:275380	12/57 (21%)
		LRR 8	275..296		6/20 (30%)
		leucine-rich repeat	276..299	CDD:275380	5/28 (18%)
		LRR 9	299..321		8/22 (36%)
		leucine-rich repeat	300..322	CDD:275380	8/22 (36%)
		LRR_8	321..382	CDD:290566	22/80 (28%)
		LRR 10	322..343		6/21 (29%)
		leucine-rich repeat	323..346	CDD:275380	6/23 (26%)
		LRR_RI	345..>541	CDD:238064	63/219 (29%)
		LRR 11	346..366		7/32 (22%)
		leucine-rich repeat	347..371	CDD:275380	8/36 (22%)
		LRR_8	371..432	CDD:290566	26/69 (38%)
		LRR 12	371..391		9/25 (36%)
		leucine-rich repeat	372..397	CDD:275380	9/24 (38%)
		LRR 13	397..418		10/23 (43%)
		leucine-rich repeat	398..421	CDD:275380	10/25 (40%)
		LRR_8	420..481	CDD:290566	21/62 (34%)
		LRR 14	421..442		7/22 (32%)
		leucine-rich repeat	422..446	CDD:275380	8/25 (32%)
		LRR 15	446..466		5/19 (26%)
		leucine-rich repeat	447..470	CDD:275380	7/22 (32%)
		LRR 16	470..493		7/22 (32%)
		leucine-rich repeat	471..497	CDD:275380	7/25 (28%)
		LRR_8	497..555	CDD:290566	13/64 (20%)
		LRR 17	497..518		5/20 (25%)
		leucine-rich repeat	498..521	CDD:275380	4/22 (18%)
		LRR 18	521..544		6/22 (27%)
		leucine-rich repeat	522..545	CDD:275380	6/22 (27%)
		LRR 19	546..566		4/26 (15%)
		LRRCT	577..626	CDD:214507	14/74 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910