DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Tlr7

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001277687.1	Gene:	Tlr7 / 170743	MGIID:	2176882	Length:	1053	Species:	Mus musculus

Alignment Length:	755	Identity:	164/755 - (21%)
Similarity:	259/755 - (34%)	Gaps:	273/755 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 SQITVNRTSKSASVTPTGIRENVM--------LPSADPEKEAQILYEKSLQEYHGSQLSTASTAT 131
            :.:.|:.|.|..:..|.||..|..        :||..|:...::        .|..::.......
Mouse    48 AHVIVDCTDKHLTEIPEGIPTNTTNLTLTINHIPSISPDSFRRL--------NHLEEIDLRCNCV 104

  Fly   132 DVIAGKRTLHSICERWLQ----------------------------------------------- 149
            .|:.|.:.  ::|.:.||
Mouse   105 PVLLGSKA--NVCTKRLQIRPGSFSGLSDLKALYLDGNQLLEIPQDLPSSLHLLSLEANNIFSIT 167

  Fly   150 ----------------------KHCHCTGSLE-----VLR----LSCRGIGILAVPVNLPNEVVV 183
                                  ..|:.:.|:|     |:|    ||.:...:.|||..||..::.
Mouse   168 KENLTELVNIETLYLGQNCYYRNPCNVSYSIEKDAFLVMRNLKVLSLKDNNVTAVPTTLPPNLLE 232

  Fly   184 LDLGNNNLTKLEANSFFMAPNLEELTLSD--------------------NSIINMDPNAFYGLAK 228
            |.|.||.:.|::.|.|   .||.||.:.|                    ||.:.:..|||..|.:
Mouse   233 LYLYNNIIKKIQENDF---NNLNELQVLDLSGNCPRCYNVPYPCTPCENNSPLQIHDNAFNSLTE 294

  Fly   229 LKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGN----------------ALVSLD---------- 267
            ||.|.|.:..|:.:||..|:.:..|..|.|:.|                .||.||
Mouse   295 LKVLRLHSNSLQHVPPTWFKNMRNLQELDLSQNYLAREIEEAKFLHFLPNLVELDFSFNYELQVY 359

  Fly   268 ------GDCLGHLQKLRTLRLEGNLFYRIPTNALAGLR---TLEALNLGSNLLTIINDEDFPRMP 323
                  ...|..|:.|:.||::|.:|..:..::|:.|.   .||.|:||:|.:.|.:...|....
Mouse   360 HASITLPHSLSSLENLKILRVKGYVFKELKNSSLSVLHKLPRLEVLDLGTNFIKIADLNIFKHFE 424

  Fly   324 NLIV------------------------------------------------------------- 327
            ||.:
Mouse   425 NLKLIDLSVNKISPSEESREVGFCPNAQTSVDRHGPQVLEALHYFRYDEYARSCRFKNKEPPSFL 489

  Fly   328 ------------LLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEG--LSKLSQLQELSIT 378
                        |.|.||.|..|.....::|:.||.|.|..|.|.....|  |..|.:|:.|..:
Mouse   490 PLNADCHIYGQTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSELWPLRELRYLDFS 554

  Fly   379 SNRLRWINDT--ELPRSMQMLDMRANPLSTISPGAFRGMS---KLR---KLILSD-------VRT 428
            :|||..:..|  |..:|:::||:.:|.....:.|....::   |||   ||:::|       .||
Mouse   555 NNRLDLLYSTAFEELQSLEVLDLSSNSHYFQAEGITHMLNFTKKLRLLDKLMMNDNDISTSASRT 619

  Fly   429 LRS----FPELEACHA--------------------LEILKLDRAGIQEVPANLCR-QTPRLKSL 468
            :.|    ..|....|.                    ||:|.:.|..:..:|..:.. ..|.||:|
Mouse   620 MESDSLRILEFRGNHLDVLWRAGDNRYLDFFKNLFNLEVLDISRNSLNSLPPEVFEGMPPNLKNL 684

  Fly   469 ELKTNSLKRI--PNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQG 531
            .|..|.||..  ..|...:.|.:||||.||:.|:..:..|..|.|..|:|.:|:|:.|.:...:.
Mouse   685 SLAKNGLKSFFWDRLQLLKHLEILDLSHNQLTKVPERLANCSKSLTTLILKHNQIRQLTKYFLED 749

  Fly   532 IPKLQLLDLEGNEISYIHKEAF--SGFTALEDLNLGNNIF 569
            ..:|:.||:..|:|..|.|.:|  :....||.|.|.:|.|
Mouse   750 ALQLRYLDISSNKIQVIQKTSFPENVLNNLEMLVLHHNRF 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	9/29 (31%)
		LRR_RI	180..>383	CDD:238064	73/332 (22%)
		leucine-rich repeat	183..204	CDD:275380	7/20 (35%)
		LRR_8	203..263	CDD:290566	23/95 (24%)
		leucine-rich repeat	205..228	CDD:275380	10/42 (24%)
		leucine-rich repeat	229..252	CDD:275380	8/22 (36%)
		LRR_8	252..311	CDD:290566	23/93 (25%)
		leucine-rich repeat	253..276	CDD:275380	10/54 (19%)
		leucine-rich repeat	277..300	CDD:275380	7/25 (28%)
		LRR_8	299..359	CDD:290566	22/135 (16%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..348	CDD:275380	8/95 (8%)
		LRR_RI	327..567	CDD:238064	81/358 (23%)
		leucine-rich repeat	349..371	CDD:275380	9/23 (39%)
		LRR_8	370..425	CDD:290566	17/62 (27%)
		leucine-rich repeat	372..393	CDD:275380	7/22 (32%)
		leucine-rich repeat	394..415	CDD:275380	4/20 (20%)
		leucine-rich repeat	418..486	CDD:275380	24/104 (23%)
		leucine-rich repeat	441..464	CDD:275378	5/23 (22%)
		LRR_8	487..545	CDD:290566	20/57 (35%)
		leucine-rich repeat	487..510	CDD:275380	9/22 (41%)
		leucine-rich repeat	511..534	CDD:275380	6/22 (27%)
		LRR_8	533..589	CDD:290566	14/39 (36%)
		leucine-rich repeat	535..558	CDD:275380	8/24 (33%)
		leucine-rich repeat	559..580	CDD:275380	6/11 (55%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Tlr7	NP_001277687.1	PRK15370	<35..>246	CDD:185268	33/207 (16%)
		leucine-rich repeat	51..72	CDD:275380	7/20 (35%)
		leucine-rich repeat	73..93	CDD:275380	3/27 (11%)
		leucine-rich repeat	94..131	CDD:275380	5/38 (13%)
		leucine-rich repeat	132..155	CDD:275380	0/22 (0%)
		PLN00113	177..>789	CDD:215061	147/614 (24%)
		leucine-rich repeat	177..208	CDD:275380	4/30 (13%)
		leucine-rich repeat	209..229	CDD:275380	7/19 (37%)
		leucine-rich repeat	230..253	CDD:275380	9/25 (36%)
		leucine-rich repeat	254..294	CDD:275380	8/39 (21%)
		leucine-rich repeat	295..318	CDD:275380	8/22 (36%)
		leucine-rich repeat	319..344	CDD:275380	4/24 (17%)
		leucine-rich repeat	345..401	CDD:275380	13/55 (24%)
		leucine-rich repeat	402..425	CDD:275380	8/22 (36%)
		leucine-rich repeat	500..522	CDD:275380	7/21 (33%)
		leucine-rich repeat	523..547	CDD:275380	9/23 (39%)
		leucine-rich repeat	548..571	CDD:275380	7/22 (32%)
		leucine-rich repeat	572..601	CDD:275380	6/28 (21%)
		leucine-rich repeat	602..624	CDD:275380	6/21 (29%)
		leucine-rich repeat	625..655	CDD:275380	2/29 (7%)
		leucine-rich repeat	656..680	CDD:275380	5/23 (22%)
		leucine-rich repeat	681..704	CDD:275380	8/22 (36%)
		leucine-rich repeat	705..728	CDD:275380	9/22 (41%)
		leucine-rich repeat	753..778	CDD:275380	8/24 (33%)
		PCC	757..>841	CDD:188093	12/33 (36%)
		TIR	894..1039	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910