DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Lhcgr

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_038610.1	Gene:	Lhcgr / 16867	MGIID:	96783	Length:	700	Species:	Mus musculus

Alignment Length:	750	Identity:	242/750 - (32%)
Similarity:	366/750 - (48%)	Gaps:	157/750 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   342 ALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNR------------LRWINDTELPRS- 393
            ||:.|..|.:|.|             |.|||....::.:|            ||...    ||:
Mouse     7 ALRQLLVLAMLVL-------------KQSQLHSPELSGSRCPEPCDCAPDGALRCPG----PRAG 54

  Fly   394 MQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQE----- 453
            :..|.:...|:..|...||||::::.|:.:|...:|.   .:||.....:|.|....||.
Mouse    55 LARLSLTYLPVKVIPSQAFRGLNEVVKIEISQSDSLE---RIEANAFDNLLNLSEILIQNTKNLL 116

  Fly   454 -VPANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLS 517
             :........||||.|.:....::.:|::|                ||....||.:.::.|.|.
Mouse   117 YIEPGAFTNLPRLKYLSICNTGIRTLPDVS----------------KISSSEFNFILEICDNLY- 164

  Fly   518 YNRIKALPQDAFQGIPKLQL-LDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPE---------- 571
               |..:|.:||||:....: |.|.||....:...||:| |.|..|.|..||:.|
Mouse   165 ---ITTIPGNAFQGMNNESITLKLYGNGFEEVQSHAFNG-TTLISLELKENIYLEKMHSGTFQGA 225

  Fly   572 ---------------LPESGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSYAYHCCAF--LP 619
                           ||..||.::..|...::..|:..|..:.|..:....|:|..|||||  ||
Mouse   226 TGPSILDVSSTKLQALPSHGLESIQTLIATSSYSLKTLPSREKFTSLLVATLTYPSHCCAFRNLP 290

  Fly   620 LVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEE 684
                   ||            :..|..:::           .|.|||..:::.:.       |.|
Mouse   291 -------KK------------EQNFSFSIF-----------ENFSKQCESTVREA-------NNE 318

  Fly   685 QLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQPGSVQCLPMPGPFLPCAD 749
            .|.:            ..|||:::||....|.|            ..|.::||.|.|..|.||.|
Mouse   319 TLYS------------AIFEENELSGWDYDYDF------------CSPKTLQCTPEPDAFNPCED 359

  Fly   750 LFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDA 814
            :..:..||..:|::.:|::.||.||:||||.||.|:.|||||:|||:.|||.||:||.::|.||:
Mouse   360 IMGYAFLRVLIWLINILAIFGNLTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDS 424

  Fly   815 ATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGY 879
            .|.|::...||.||....|..:||..|.:||||||||.||||||.:.||:|:.|:::|.|:.|..
Mouse   425 QTKGQYYNHAIDWQTGSGCSAAGFFTVFASELSVYTLTVITLERWHTITYAVQLDQKLRLRHAIP 489

  Fly   880 IMSVGWVFALIMALMPLVGVSDYRKFAVCLPFETTTGPASLTYVISLMFINGCAFLTLMGCYLKM 944
            ||..||:|:.:||.:||||||.|.|.::|||.:..: ..|..|::|::.:|..||:.:..||:::
Mouse   490 IMLGGWIFSTLMATLPLVGVSSYMKVSICLPMDVES-TLSQVYILSILLLNAVAFVVICACYVRI 553

  Fly   945 YWAIRGSQAWNTN-DSRIAKRMALLVFTDFLCWSPIAFFSITAIFGLQLISLEQAKIFTVFVLPL 1008
            |:|::..:....| |::|||:||:|:||||.|.:||:||:|:|.|.:.||::..:|:..|...|:
Mouse   554 YFAVQNPELTAPNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPV 618

  Fly  1009 NSCCNPFLYAIMTKQFKKDCVTL------CKHFEE 1037
            |||.||||||:.||.|::|...|      |||..|
Mouse   619 NSCANPFLYAVFTKAFQRDFFLLLSRFGCCKHRAE 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	11/52 (21%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566	6/16 (38%)
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380	3/5 (60%)
		LRR_RI	327..567	CDD:238064	61/244 (25%)
		leucine-rich repeat	349..371	CDD:275380	4/21 (19%)
		LRR_8	370..425	CDD:290566	16/67 (24%)
		leucine-rich repeat	372..393	CDD:275380	5/32 (16%)
		leucine-rich repeat	394..415	CDD:275380	6/20 (30%)
		leucine-rich repeat	418..486	CDD:275380	16/73 (22%)
		leucine-rich repeat	441..464	CDD:275378	4/28 (14%)
		LRR_8	487..545	CDD:290566	16/58 (28%)
		leucine-rich repeat	487..510	CDD:275380	4/22 (18%)
		leucine-rich repeat	511..534	CDD:275380	8/22 (36%)
		LRR_8	533..589	CDD:290566	19/81 (23%)
		leucine-rich repeat	535..558	CDD:275380	7/23 (30%)
		leucine-rich repeat	559..580	CDD:275380	10/45 (22%)
		7tm_4	764..>892	CDD:304433	66/127 (52%)
		7tm_1	770..1017	CDD:278431	119/247 (48%)
Lhcgr	NP_038610.1	LRR 1	52..75		6/22 (27%)
		leucine-rich repeat	55..78	CDD:275380	7/22 (32%)
		LRR_5	66..204	CDD:290045	41/161 (25%)
		leucine-rich repeat	79..103	CDD:275380	5/26 (19%)
		leucine-rich repeat	104..128	CDD:275380	3/23 (13%)
		LRR 2	126..150		9/39 (23%)
		leucine-rich repeat	129..150	CDD:275380	7/36 (19%)
		leucine-rich repeat	155..178	CDD:275380	8/26 (31%)
		LRR 3	176..200		6/23 (26%)
		leucine-rich repeat	180..202	CDD:275380	7/22 (32%)
		leucine-rich repeat	203..227	CDD:275380	6/23 (26%)
		LRR 4	225..248		4/22 (18%)
		leucine-rich repeat	228..248	CDD:275380	4/19 (21%)
		7tm_1	380..627	CDD:278431	119/247 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810