DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Lrig1

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_032403.2	Gene:	Lrig1 / 16206	MGIID:	107935	Length:	1091	Species:	Mus musculus

Alignment Length:	446	Identity:	130/446 - (29%)
Similarity:	199/446 - (44%)	Gaps:	70/446 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |.|.|.    .|.|.|.|:..:|.:||:....|:|..|.|:::::.:|....||:|:.|:.|.:
Mouse    47 CTCAGD----SLDCSGRGLATLPRDLPSWTRSLNLSYNRLSEIDSAAFEDLTNLQEVYLNSNEL- 106

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLR 281
                           .::.:.|..|:         .:.||.|..|.::|:||
Mouse   107 ---------------TAIPSLGAASI---------GVVSLFLQHNKILSVDG------------- 134

  Fly   282 LEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNL 346
                       :.|....:||.|:|.||.:|.|....||....:..|.|..|:|..:.:||...|
Mouse   135 -----------SQLKSYLSLEVLDLSSNNITEIRSSCFPNGLRIRELNLASNRISILESGAFDGL 188

  Fly   347 T-ALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELP--RSMQMLDMRANPLSTIS 408
            : :|..|.|..|.|:.||....||.:|.:|.:..||:|.|......  .|:::|.::.|.:|.::
Mouse   189 SRSLLTLRLSKNRITQLPVKAFKLPRLTQLDLNRNRIRLIEGLTFQGLDSLEVLRLQRNNISRLT 253

  Fly   409 PGAFRGMSKLRKLILS-----DVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSL 468
            .|||.|:||:..|.|.     :|.: .|...|.|.|.|.:.....:.||....:.|:   :|..|
Mouse   254 DGAFWGLSKMHVLHLEYNSLVEVNS-GSLYGLTALHQLHLSNNSISRIQRDGWSFCQ---KLHEL 314

  Fly   469 ELKTNSLKRI--PNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQD---A 528
            .|..|:|.|:  .:|:....|.:|.||.|.|..|....|.|||.|..|.|.:|.|....:|   |
Mouse   315 ILSFNNLTRLDEESLAELSSLSILRLSHNAISHIAEGAFKGLKSLRVLDLDHNEISGTIEDTSGA 379

  Fly   529 FQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLK 584
            |.|:..|..|.|.||:|..:.|.||||..:||.||||.|....:.......:.:||
Mouse   380 FTGLDNLSKLTLFGNKIKSVAKRAFSGLESLEHLNLGENAIRSVQFDAFAKMKNLK 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	6/20 (30%)
		LRR_RI	180..>383	CDD:238064	50/203 (25%)
		leucine-rich repeat	183..204	CDD:275380	5/20 (25%)
		LRR_8	203..263	CDD:290566	11/59 (19%)
		leucine-rich repeat	205..228	CDD:275380	4/22 (18%)
		leucine-rich repeat	229..252	CDD:275380	2/22 (9%)
		LRR_8	252..311	CDD:290566	14/58 (24%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	1/22 (5%)
		LRR_8	299..359	CDD:290566	21/60 (35%)
		leucine-rich repeat	301..324	CDD:275380	10/22 (45%)
		leucine-rich repeat	325..348	CDD:275380	7/23 (30%)
		LRR_RI	327..567	CDD:238064	87/252 (35%)
		leucine-rich repeat	349..371	CDD:275380	9/21 (43%)
		LRR_8	370..425	CDD:290566	18/61 (30%)
		leucine-rich repeat	372..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..415	CDD:275380	6/20 (30%)
		leucine-rich repeat	418..486	CDD:275380	18/74 (24%)
		leucine-rich repeat	441..464	CDD:275378	4/22 (18%)
		LRR_8	487..545	CDD:290566	25/60 (42%)
		leucine-rich repeat	487..510	CDD:275380	10/22 (45%)
		leucine-rich repeat	511..534	CDD:275380	9/25 (36%)
		LRR_8	533..589	CDD:290566	20/52 (38%)
		leucine-rich repeat	535..558	CDD:275380	11/22 (50%)
		leucine-rich repeat	559..580	CDD:275380	7/20 (35%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Lrig1	NP_032403.2	leucine-rich repeat	53..71	CDD:275380	7/17 (41%)
		LRR_RI	57..325	CDD:238064	84/320 (26%)
		LRR 1	71..92		5/20 (25%)
		leucine-rich repeat	72..95	CDD:275380	5/22 (23%)
		LRR_8	73..129	CDD:290566	16/80 (20%)
		LRR 2	95..116		6/36 (17%)
		LRR 3	118..139		8/44 (18%)
		LRR_8	142..225	CDD:290566	29/82 (35%)
		LRR 4	142..163		9/20 (45%)
		leucine-rich repeat	143..166	CDD:275380	10/22 (45%)
		LRR 5	166..187		6/20 (30%)
		leucine-rich repeat	167..190	CDD:275380	7/22 (32%)
		leucine-rich repeat	191..214	CDD:275380	9/22 (41%)
		LRR 6	191..212		7/20 (35%)
		LRR_8	213..273	CDD:290566	18/59 (31%)
		LRR 7	214..235		6/20 (30%)
		leucine-rich repeat	215..238	CDD:275380	6/22 (27%)
		LRR_RI	238..>423	CDD:238064	66/188 (35%)
		LRR 8	238..259		7/20 (35%)
		leucine-rich repeat	239..262	CDD:275380	7/22 (32%)
		LRR_8	261..321	CDD:290566	17/63 (27%)
		LRR 9	262..283		5/21 (24%)
		leucine-rich repeat	263..286	CDD:275380	5/23 (22%)
		LRR 10	286..307		5/20 (25%)
		leucine-rich repeat	287..310	CDD:275380	5/25 (20%)
		LRR_8	310..369	CDD:290566	22/58 (38%)
		LRR 11	310..331		7/20 (35%)
		leucine-rich repeat	311..334	CDD:275380	7/22 (32%)
		LRR 12	334..355		8/20 (40%)
		leucine-rich repeat	335..358	CDD:275380	10/22 (45%)
		LRR 13	358..380		6/21 (29%)
		leucine-rich repeat	359..383	CDD:275380	8/23 (35%)
		LRR_8	385..441	CDD:290566	20/51 (39%)
		LRR 14	385..406		9/20 (45%)
		leucine-rich repeat	386..409	CDD:275380	11/22 (50%)
		LRR 15	409..430		7/20 (35%)
		leucine-rich repeat	410..433	CDD:275380	7/22 (32%)
		LRRCT	444..492	CDD:214507
		Ig_3	496..583	CDD:290638
		I-set	497..597	CDD:254352
		I-set	601..691	CDD:254352
		Ig_1	618..692	CDD:143240
		I-set	695..782	CDD:254352
		IGc2	709..772	CDD:197706
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	912..990
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1059..1091
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910