DRSC/TRiP Functional Genomics Resources

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Protein Alignment rk and LINGO2

DIOPT Version :9

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:NP_001245211.1 Gene:LINGO2 / 158038 HGNCID:21207 Length:606 Species:Homo sapiens


Alignment Length:539 Identity:138/539 - (25%)
Similarity:223/539 - (41%) Gaps:83/539 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |.|  |.:...:||....::|:|..:|.|..:|||..|.|..:....|...|.|||:.||||.|.
Human    32 CEC--SAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIA 94

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLR 281
            |::|.||..|..|:.|.|:...||.:|...|.||:.||.|.::.|.:|.|.......|..|::|.
Human    95 NVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLE 159

  Fly   282 LEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNL 346
            :..|....|...|.:||.:||.|.|....||.:..|....:.:||.|.||...|..:...|.|.|
Human   160 VGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRL 224

  Fly   347 TALKVLELDD-NLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQM--LDMRANPLSTIS 408
            ..||.||:|. .|:..:|........|..||:|:..|..:........:.:  |::..||:|||.
Human   225 FHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIE 289

  Fly   409 PGAFRGMSKLRKL--ILSDVRTL--RSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLE 469
            .|.|..:.:|::|  :.:.:||:  .||   :....|.:|.:.:..::.:..|:......|:.|.
Human   290 AGMFSDLIRLQELHIVGAQLRTIEPHSF---QGLRFLRVLNVSQNLLETLEENVFSSPRALEVLS 351

  Fly   470 LKTNSLKRIPNLSSCRDLRLLDLSSNQ-----------------IEKIQGKPFNGL--------- 508
            :..|.|       :| |.|||.:...|                 |.:...|.|:..         
Human   352 INNNPL-------AC-DCRLLWILQRQPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCK 408

  Fly   509 ------KQLNDLLLSYNRIKAL-------PQDAFQGI-PKLQLLDLEGN-----------EISYI 548
                  |:|..||:...:...|       ||.....: |:.:.:..:.|           ||.:.
Human   409 KPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFA 473

  Fly   549 HKEAFSGFTALEDLNLGNNIF-PELPESGL---------RALLHLKTFNNPKLREFPPPDTFP-R 602
            ..:....:..:.....||:.| ..|...|.         |..::: |.:|..:......:||. .
Human   474 QDQDSGMYVCIASNAAGNDTFTASLTVKGFASDRFLYANRTPMYM-TDSNDTISNGTNANTFSLD 537

  Fly   603 IQTLILSYAYHCCAFLPLV 621
            ::|:::|.|..|..||.:|
Human   538 LKTILVSTAMGCFTFLGVV 556

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380 4/20 (20%)
LRR_RI 180..>383 CDD:238064 71/203 (35%)
leucine-rich repeat 183..204 CDD:275380 6/20 (30%)
LRR_8 203..263 CDD:290566 27/59 (46%)
leucine-rich repeat 205..228 CDD:275380 13/22 (59%)
leucine-rich repeat 229..252 CDD:275380 9/22 (41%)
LRR_8 252..311 CDD:290566 18/58 (31%)
leucine-rich repeat 253..276 CDD:275380 7/22 (32%)
leucine-rich repeat 277..300 CDD:275380 7/22 (32%)
LRR_8 299..359 CDD:290566 21/60 (35%)
leucine-rich repeat 301..324 CDD:275380 7/22 (32%)
leucine-rich repeat 325..348 CDD:275380 9/22 (41%)
LRR_RI 327..567 CDD:238064 61/297 (21%)
leucine-rich repeat 349..371 CDD:275380 7/22 (32%)
LRR_8 370..425 CDD:290566 15/58 (26%)
leucine-rich repeat 372..393 CDD:275380 5/20 (25%)
leucine-rich repeat 394..415 CDD:275380 8/22 (36%)
leucine-rich repeat 418..486 CDD:275380 14/71 (20%)
leucine-rich repeat 441..464 CDD:275378 3/22 (14%)
LRR_8 487..545 CDD:290566 16/108 (15%)
leucine-rich repeat 487..510 CDD:275380 7/54 (13%)
leucine-rich repeat 511..534 CDD:275380 6/30 (20%)
LRR_8 533..589 CDD:290566 11/76 (14%)
leucine-rich repeat 535..558 CDD:275380 3/33 (9%)
leucine-rich repeat 559..580 CDD:275380 6/30 (20%)
7tm_4 764..>892 CDD:304433
7tm_1 770..1017 CDD:278431
LINGO2NP_001245211.1 LRRNT 27..60 CDD:214470 9/29 (31%)
leucine-rich repeat 39..57 CDD:275380 4/17 (24%)
LRR 1 58..79 7/20 (35%)
leucine-rich repeat 59..82 CDD:275380 6/22 (27%)
LRR_8 60..117 CDD:316378 23/56 (41%)
LRR 2 82..103 12/20 (60%)
leucine-rich repeat 83..106 CDD:275380 13/22 (59%)
LRR_8 106..165 CDD:316378 19/58 (33%)
LRR 3 106..127 7/20 (35%)
leucine-rich repeat 107..130 CDD:275380 9/22 (41%)
LRR 4 130..151 6/20 (30%)
leucine-rich repeat 131..154 CDD:275380 7/22 (32%)
LRR_5 146..276 CDD:331043 36/129 (28%)
LRR 5 154..175 5/20 (25%)
leucine-rich repeat 155..178 CDD:275380 7/22 (32%)
LRR 6 178..199 7/20 (35%)
leucine-rich repeat 179..202 CDD:275380 7/22 (32%)
LRR 7 202..223 7/20 (35%)
leucine-rich repeat 203..250 CDD:275380 16/46 (35%)
LRR 8 226..247 7/20 (35%)
LRR_8 250..309 CDD:316378 15/58 (26%)
LRR 9 250..271 5/20 (25%)
leucine-rich repeat 251..274 CDD:275380 5/22 (23%)
LRR 10 274..295 8/20 (40%)
leucine-rich repeat 275..298 CDD:275380 8/22 (36%)
LRR_8 298..357 CDD:316378 12/61 (20%)
LRR 11 298..319 6/23 (26%)
leucine-rich repeat 299..322 CDD:275380 6/25 (24%)
LRR 12 322..343 3/20 (15%)
leucine-rich repeat 323..343 CDD:275380 3/19 (16%)
PCC 327..>391 CDD:188093 12/71 (17%)
I-set 410..500 CDD:254352 15/89 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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